Novel olfactory ligands via terpene synthases
Touchet, S., Chamberlain, Keith, Woodcock, Christine, Miller, D. J., Birkett, Mike
, Pickett, John and Allemann, R. K.
(2015)
Novel olfactory ligands via terpene synthases.
Chemical Communications, 51 (35).
pp. 7550-7553.
10.1039/c5cc01814e
, Pickett, John and Allemann, R. K.
(2015)
Novel olfactory ligands via terpene synthases.
Chemical Communications, 51 (35).
pp. 7550-7553.
10.1039/c5cc01814e
A synthetic biology approach to the rational design of analogues of olfactory ligands by providing unnatural substrates for the enzyme synthesising (S)-germacrene D, an olfactory ligand acting as a plant derived insect repellent, to produce novel ligands is described as a viable alternative to largely unsuccessful ligand docking studies. (S)-14,15-Dimethylgermacrene D shows an unexpected reversal in behavioural activity.
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