The use of substituted alkynyl phenoxy derivatives of piperonyl butoxide to control insecticide-resistant pests
Philippou, D., Borzatta, V., Capparella, E., Moroni, L., Field, Lin
and Moores, G. D.
(2016)
The use of substituted alkynyl phenoxy derivatives of piperonyl butoxide to control insecticide-resistant pests.
Pest Management Science, 72 (10).
pp. 1946-1950.
10.1002/ps.4234
and Moores, G. D.
(2016)
The use of substituted alkynyl phenoxy derivatives of piperonyl butoxide to control insecticide-resistant pests.
Pest Management Science, 72 (10).
pp. 1946-1950.
10.1002/ps.4234
BACKGROUNDDerivatives of piperonyl butoxide with alkynyl side chains were tested in vitro and in vivo against pyrethroid-resistant Meligethes aeneus and imidacloprid-resistant Myzus persicae. RESULTSSynergists with the alkynyl side chain were more effective inhibitors of P450 activity in vitro than piperonyl butoxide, and demonstrated high levels of synergism in vivo, with up to 290-fold synergism of imidacloprid against imidacloprid-resistant M. persicae. CONCLUSIONSThese second-generation' synergists could overcome metabolic resistance in many pest species and possibly enable reduced rates of insecticide application in some cases. (c) 2016 Society of Chemical Industry
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