The use of substituted alkynyl phenoxy derivatives of piperonyl butoxide to control insecticide-resistant pests

Philippou, D., Borzatta, V., Capparella, E., Moroni, L., Field, Lin

and Moores, G. D. (2016) The use of substituted alkynyl phenoxy derivatives of piperonyl butoxide to control insecticide-resistant pests. Pest Management Science, 72 (10). pp. 1946-1950. 10.1002/ps.4234

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BACKGROUNDDerivatives of piperonyl butoxide with alkynyl side chains were tested in vitro and in vivo against pyrethroid-resistant Meligethes aeneus and imidacloprid-resistant Myzus persicae. RESULTSSynergists with the alkynyl side chain were more effective inhibitors of P450 activity in vitro than piperonyl butoxide, and demonstrated high levels of synergism in vivo, with up to 290-fold synergism of imidacloprid against imidacloprid-resistant M. persicae. CONCLUSIONSThese second-generation' synergists could overcome metabolic resistance in many pest species and possibly enable reduced rates of insecticide application in some cases. (c) 2016 Society of Chemical Industry

Item Type	Article
Open Access	Not Open Access
Additional information	[Moores, Graham] ApresLabs Ltd, Harpenden AL5 2JQ, Herts, England; [Philippou, Despina; Field, Linda] Rothamsted Res, Harpenden, Herts, England; [Philippou, Despina] Dept Agr, Plant Protect Sect, Nicosia, Cyprus; [Borzatta, Valerio; Capparella, Elisa; Moroni, Leni] Endura SpA, Ravenna, Italy
Keywords	Agronomy, Entomology
Project	Delivering Sustainable Systems (SS) [ISPG]
Date Deposited	05 Dec 2025 09:52
Last Modified	21 Jan 2026 17:20