Miyabeacin: A new cyclodimer presents a potential role for willow in cancer therapy.
Ward, Jane, Wu, Y., Harflett, Claudia
, Onafuye, H., Corol, Delia, Lomax, Charlotte, Macalpine, William, Cinatl, J., Wass, M. N., Michaelis, M. and +1 more...Beale, Mike
(2020)
Miyabeacin: A new cyclodimer presents a potential role for willow in cancer therapy.
Scientific Reports, 10.
p. 6477.
10.1038/s41598-020-63349-1
, Onafuye, H., Corol, Delia, Lomax, Charlotte, Macalpine, William, Cinatl, J., Wass, M. N., Michaelis, M. and +1 more...Beale, Mike
(2020)
Miyabeacin: A new cyclodimer presents a potential role for willow in cancer therapy.
Scientific Reports, 10.
p. 6477.
10.1038/s41598-020-63349-1
Willow (Salix spp.) is well known as a source of medicinal compounds, the most famous being salicin, the progenitor of aspirin. Here we describe the isolation, structure determination, and anti-cancer activity of a cyclodimeric salicinoid (miyabeacin) from S. miyabeana and S. dasyclados. We also show that the capability to produce such dimers is a heritable trait and how variation in structures of natural miyabeacin analogues is derived via cross-over Diels-Alder reactions from pools of ortho-quinol precursors. These transient ortho-quinols have a role in the, as yet uncharacterised, biosynthetic pathways around salicortin, the major salicinoid of many willow genotypes.
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picture_as_pdf - 308824_2_figure_8660174_q7st8t_convrt.pdf
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subject - Accepted Version
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- Available under Creative Commons: Attribution 4.0
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