A stable start - cotranslational Nt-acetylation promotes proteome stability across kingdoms

Gibbs, D. J., Bailey, Mark

and Etherington, R. D. (2022) A stable start - cotranslational Nt-acetylation promotes proteome stability across kingdoms. Trends in Cell biology, 32 (5). pp. 374-376. 10.1016/j.tcb.2022.02.004

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Two recent studies show that cotranslational N-terminal protein acetylation (NTA) promotes pro�teome stability in humans (Mueller et al.) and plants (Linster et al.) by masking nonacetylated N-degrons that would otherwise destabilise proteins. This is in contrast to previous findings linking NTA to degradation, suggesting that this widespread mark has complex and context-specific functions in regulating protein half-lives

Item Type	Article
Open Access	Green
Additional information	Paid for access, please don't add manuscript to public repository This work was supported by a European Research Council Starting Grant (ERC-StG 715441-GasPlaNt) and Biotechnology and Biological Sciences Research Council grant (BB/V008587/1) to D.J.G.
Keywords	Acetylation , N-degron pathway, Proteostasis, N terminus, Cotranslational modification, Proteolysis
Project	Tailoring Plant Metabolism (TPM) - Work package 1 (WP1) - High value lipids for health and industry, BB/V008587/1, ERC-StG 715441-GasPlaNt
Date Deposited	05 Dec 2025 10:34
Last Modified	19 Dec 2025 14:55