A Two-Step Process for Converting Methane to Canthaxanthin Using Methylococcus capsulatus (Bath) Biomass and Engineered Yarrowia lipolytica

Taratynova, M. O., Tarasov, I. M., Fedyaeva, I. M., Dementev, D. A., Gorchakova, V. A., Tarasova, M. A., Fedorov, A. S., Yuzbashev, TigranORCID logo, Sineoky, S. P. and Yuzbasheva, E. Y. (2025) A Two-Step Process for Converting Methane to Canthaxanthin Using Methylococcus capsulatus (Bath) Biomass and Engineered Yarrowia lipolytica. Biotechnology Journal, 20 (6). e70043. 10.1002/biot.70043
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Methane biotransformation is gaining attention for the bio-industry and environmental protection. This study presents an approach for converting methane to canthaxanthin using Methylococcus capsulatus biomass and Yarrowia lipolytica. Y. lipolytica was engineered to introduce the canthaxanthin biosynthesis pathway, increase the acetyl-CoA flux, and boost hexose catabolism. In methanotroph-derived medium with molasses, canthaxanthin titer reached 1.2 g/L, advancing cost-effective, sustainable bioproduction.
Item Type Article
Open Access Not Open Access
Additional information Funding: This work was supported by the Ministry of Science and Higher Education of the Russian Federation (grant number 075–15-2019–1659). The work wascarried out within the state assignment of NRC «Kurchatov Institute».
Keywords Canthaxanthin , Methane, Methanotroph protein hydrolysate, Molasses , Yarrowia lipolytica
Date Deposited 05 Dec 2025 10:46
Last Modified 19 Dec 2025 14:58

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