Rapid selection for resistance to diamide insecticides in Plutella xylostella via specific amino acid polymorphisms in the ryanodine receptor

A - Papers appearing in refereed journals

Troczka, B. J., Williamson, M. S., Field, L. M. and Davies, T. G. E. 2017. Rapid selection for resistance to diamide insecticides in Plutella xylostella via specific amino acid polymorphisms in the ryanodine receptor. Neurotoxicology. 60 (May), pp. 224-233.

AuthorsTroczka, B. J., Williamson, M. S., Field, L. M. and Davies, T. G. E.
Abstract

Diamide insecticides, such as flubendiamide and chlorantraniliprole, are a new class of insecticide with a novel mode of action, selectively activating the insect ryanodine receptor (RyR). They are particularly active against lepidopteran pests of cruciferous vegetable crops, including the diamondback moth, Plutella xylostella. However, within a relatively short period following their commercialisation, a comparatively large number of control failures have been reported in the field. In this review we summarise the current body of knowledge regarding the molecular mechanisms of diamide resistance in P. xylostella. Resistant phenotypes collected from different countries can often be linked to specific target site mutation(s) in the ryanodine receptors' transmembrane domain. Metabolic mechanisms of resistance have also been proposed. Rapid resistance development is probably a consequence of over-reliance on this one class of chemistry for diamondback moth control.

KeywordsRyanodine receptor; Diamides; Plutella xylostella; Diamondback moth; Cruciferous crops
Year of Publication2017
JournalNeurotoxicology
Journal citation60 (May), pp. 224-233
Digital Object Identifier (DOI)doi:10.1016/j.neuro.2016.05.012
PubMed ID27246647
Open accessPublished as ‘gold’ (paid) open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeBBSRC Strategic Programme in Smart Crop Protection
Publisher's version
Copyright license
CC BY
Output statusPublished
Publication dates
Online28 May 2017
Publication process dates
Accepted19 May 2016
PublisherElsevier Science Bv
ISSN0161-813X

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