Fitness Penalties in the Evolution of Fungicide Resistance

A - Papers appearing in refereed journals

Hawkins, N. J. and Fraaije, B. A. 2018. Fitness Penalties in the Evolution of Fungicide Resistance. Annual Review of Phytopathology. 56, pp. 339-360.

AuthorsHawkins, N. J. and Fraaije, B. A.
Abstract

The evolution of resistance poses an ongoing threat to crop protection. Fungicide resistance provides a selective advantage under fungicide selection, but resistance-conferring mutations may also result in fitness penalties, resulting in an evolutionary trade-off. These penalties may result from the functional constraints of an evolving target site or from the resource allocation costs of overexpression or active transport. The extent to which such fitness penalties are present has important implications for resistance management strategies, determining whether resistance persists or declines between treatments, and for resistance risk assessments for new modes of action. Experimental results have proven variable, depending on factors such as temperature, nutrient status, osmotic or oxidative stress, and pathogen life-cycle stage. Functional genetics tools allow pathogen genetic background to be controlled, but this in turn raises the question of epistatic interactions. Combining fitness penalties under various conditions into a field-realistic scenario poses an important future challenge.

Keywordsfungicides; azoles; resistance; fitness penalties; evolution; resistance management
Year of Publication2018
JournalAnnual Review of Phytopathology
Journal citation56, pp. 339-360
Digital Object Identifier (DOI)doi:10.1146/annurev-phyto-080417-050012
PubMed ID29958074
Web address (URL)https://www.annualreviews.org/doi/abs/10.1146/annurev-phyto-080417-050012#_i1
Open accessPublished as green open access
Funder project or codeBBSRC Strategic Programme in Smart Crop Protection
FunderBiotechnology and Biological Sciences Research Council
Output statusPublished
Publication dates
Online01 Aug 2018
Publication process dates
Accepted29 Jun 2018
Copyright licensePublisher copyright
PublisherAnnual Reviews
ISSN0066-4286

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