Persistence and efficacy of a new formulation based on dog allomonal repellents against Rhipicephalus sanguineus sensu lato tick

A - Papers appearing in refereed journals

De Oliveira Filho, J. G., Ferreira, L. L., De Oliveria Silva, F., Menezes, K. M. F., Muniz, E. R., De Paula, L. G. F., Sarria, A. L. F., Pickett, J. A., Birkett, M. A., Mascarin, G. M. and Borges, L. M. F. 2018. Persistence and efficacy of a new formulation based on dog allomonal repellents against Rhipicephalus sanguineus sensu lato tick. Revista Brasileira de Parasitologia Veterinária. 27 (3), pp. 313-318.

AuthorsDe Oliveira Filho, J. G., Ferreira, L. L., De Oliveria Silva, F., Menezes, K. M. F., Muniz, E. R., De Paula, L. G. F., Sarria, A. L. F., Pickett, J. A., Birkett, M. A., Mascarin, G. M. and Borges, L. M. F.
Abstract

Beagles are less susceptible to Rhipicephalus sanguineus sensu lato tick due to the production of the allomones
benzaldehyde and 2-hexanone. Our previous published work showed that these compounds can reduce tick burden on
susceptible dogs. Here we tested the hypothesis that an increase in repellent dose and release rate could increase repellent efficacy and persistence. Slow-release formulations of these compounds, with higher doses and release rates, were tested on artificially-infested dogs. Ten dogs were randomly assigned to two groups with five dogs each. The treated group received collars with slow-release formulations of the compounds attached, while the control group received collars with clean formulations attached. Five environmental infestations were performed, with the number of ticks (at all stages) on the dogs being counted once a day for 40 days. No significant increase in repellent efficacy was observed with the higher doses and release rates, whereas a greater persistence in repellent activity was observed. Treatment with the formulations resulted in a two-to-three-fold reduction in the number of immature stage ticks for up to three weeks. However, the number of adults was similar in both groups. Loss of repellent activity after the third week of testing coincided with a marked change in the relative release rates for the two compounds. It is hypothesized that relative amounts, rather than absolute amounts, of repellent release from slow-release formulations are important for repellent activity. We also hypothesize that the avoidance of less-preferred hosts by ticks relies on olfactory-mediated perception of specific blends of volatile cues from less preferred hosts.

KeywordsBenzaldehyde; 2-Hexanone; Slow release formulation; Tick control
Year of Publication2018
JournalRevista Brasileira de Parasitologia Veterinária
Journal citation27 (3), pp. 313-318
Digital Object Identifier (DOI)doi:10.1590/S1984-296120180054
Web address (URL)http://rbpv.org.br/download/2732018/rbpv_2732018_313-318
Open accessPublished as green open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeBilateral BBSRC-FAPESP: Defining the Genetic and Semiochemical Basis of Tick Resistance in Cattle
Publisher's version
Output statusPublished
Publication dates
Online01 Sep 2018
Publication process dates
Accepted12 Jun 2018
PublisherColégio Brasileiro de Parasitologia Veterinária
Copyright licenseCC BY
ISSN1984-2961

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