Functional analysis of a rat sodium channel carrying a mutation for insect knock-down resistance (kdr ) to pyrethroids

A - Papers appearing in refereed journals

Vais, H., Williamson, M. S., Hick, C. A., Eldursi, N., Devonshire, A. L. and Usherwood, P. N. R. 1997. Functional analysis of a rat sodium channel carrying a mutation for insect knock-down resistance (kdr ) to pyrethroids. FEBS Letters. 413 (2), pp. 327-332. https://doi.org/10.1016/S0014-5793(97)00931-9

AuthorsVais, H., Williamson, M. S., Hick, C. A., Eldursi, N., Devonshire, A. L. and Usherwood, P. N. R.
Abstract

Pyrethroid insensitivity in resistant (kdr) insects has been correlated with a leucine to phenylalanine replacement in the S6 transmembrane segment of domain II of the axonal sodium channel alpha(para)-subunit. An alpha-subunit of rat brain type II sodium channel containing this mutation has been expressed and its sensitivity to permethrin compared with that of the wild-type channel. The steady-state activation curve of the mutant was shifted 14 mV in the depolarizing direction, We propose that an equivalent shift of the sodium current activation curve in kdr insects could account for their low sensitivity to permethrin toxicity. (C) 1997 Federation of European Biochemical Societies.

KeywordsBiochemistry & Molecular Biology; Biophysics; Cell Biology
Year of Publication1997
JournalFEBS Letters
Journal citation413 (2), pp. 327-332
Digital Object Identifier (DOI)https://doi.org/10.1016/S0014-5793(97)00931-9
PubMed ID9280307
Open accessPublished as non-open access
Funder project or code235
438
Project: 051218
ISSN00145793
PublisherWiley

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