An investigation of the ionophoric characteristics of destruxin A

A - Papers appearing in refereed journals

Hinaje, M., Ford, M., Banting, L., Arkle, S. and Khambay, B. P. S. 2002. An investigation of the ionophoric characteristics of destruxin A. Archives of Biochemistry and Biophysics. 405 (1), pp. 73-77.

AuthorsHinaje, M., Ford, M., Banting, L., Arkle, S. and Khambay, B. P. S.
Abstract

Destruxin A, a cyclohexadepsipeptide related to the enniatins and beauvericin, exhibits ionophoric properties. Calcium ion mobilization across liposomal membrane barriers, for example, has been demonstrated using the calcium ion-sensitive dyes Arsenazo III and Fura-2. Initial molecular mechanics/molecular dynamics calculations indicate the potential for destruxin A to form a coordination complex with calcium in which the divalent cation is bound at the center of a sandwich formed by two molecules of destruxin A. This novel calcium ion binding may help explain the diverse biological effects exhibited by the destruxins.

KeywordsDestruxin; Molecular modeling; Calcium; Liposomes; Ionophore
Year of Publication2002
JournalArchives of Biochemistry and Biophysics
Journal citation405 (1), pp. 73-77
Digital Object Identifier (DOI)doi:10.1016/S0003-9861(02)00275-8
Open accessPublished as non-open access
Funder project or code437
514
Output statusPublished
Publication dates
Online13 Aug 2002
Copyright licensePublisher copyright
ISSN0003-9861
PublisherElsevier Science Inc

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