A - Papers appearing in refereed journals
Hinaje, M., Ford, M., Banting, L., Arkle, S. and Khambay, B. P. S. 2002. An investigation of the ionophoric characteristics of destruxin A. Archives of Biochemistry and Biophysics. 405 (1), pp. 73-77. https://doi.org/10.1016/S0003-9861(02)00275-8
Authors | Hinaje, M., Ford, M., Banting, L., Arkle, S. and Khambay, B. P. S. |
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Abstract | Destruxin A, a cyclohexadepsipeptide related to the enniatins and beauvericin, exhibits ionophoric properties. Calcium ion mobilization across liposomal membrane barriers, for example, has been demonstrated using the calcium ion-sensitive dyes Arsenazo III and Fura-2. Initial molecular mechanics/molecular dynamics calculations indicate the potential for destruxin A to form a coordination complex with calcium in which the divalent cation is bound at the center of a sandwich formed by two molecules of destruxin A. This novel calcium ion binding may help explain the diverse biological effects exhibited by the destruxins. |
Keywords | Destruxin; Molecular modeling; Calcium; Liposomes; Ionophore |
Year of Publication | 2002 |
Journal | Archives of Biochemistry and Biophysics |
Journal citation | 405 (1), pp. 73-77 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/S0003-9861(02)00275-8 |
Open access | Published as non-open access |
Funder project or code | 437 |
514 | |
Output status | Published |
Publication dates | |
Online | 13 Aug 2002 |
Copyright license | Publisher copyright |
ISSN | 0003-9861 |
Publisher | Elsevier Science Inc |
Permalink - https://repository.rothamsted.ac.uk/item/88y91/an-investigation-of-the-ionophoric-characteristics-of-destruxin-a
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