Insecticidal 2-hydroxy-3-alkyl-1,4-naphthoquinones: correlation of inhibition of ubiquinol cytochrome c oxidoreductase (complex III) with insecticidal activity

A - Papers appearing in refereed journals

Jewess, P. J., Chamberlain, K., Boogaard, A. B., Devonshire, A. L. and Khambay, B. P. S. 2002. Insecticidal 2-hydroxy-3-alkyl-1,4-naphthoquinones: correlation of inhibition of ubiquinol cytochrome c oxidoreductase (complex III) with insecticidal activity. Pest Management Science. 58 (3), pp. 243-247.

AuthorsJewess, P. J., Chamberlain, K., Boogaard, A. B., Devonshire, A. L. and Khambay, B. P. S.
Abstract

The insecticidal and in vitro activities of four homologous series of 2-hydroxy and acetoxy-3-substituted-1,4-naphthoquinones have been measured and correlated with their (Log)octanol/water partition coefficients (Log K-o/w). In vitro activity against mitochondrial complex III was only exhibited by 2-hydroxy-3-alkyl-1,4-naphthoquinones, indicating that the 2-acetoxy compounds act as proinsecticides. Good correlation was observed between in vivo activity against the two-spotted spider mite, Tetranychus urticae and inhibition of complex III isolated from blowfly flight muscle. Both hydroxy and acetoxy analogues of individual compounds exhibited similar levels of in vivo activity with optimum activity for analogues with Log K-o/w. values of 7-8. In contrast, the acetoxy derivatives showed superior in vivo activity against the tobacco whitefly, Bemisia tabaci. Complex III isolated from whitefly was optimally inhibited by hydroxy analogues with lower Log K-o/w values (6.0-6.5) and was also more sensitive than the blowfly enzyme to all the compounds tested. (C) 2002 Society of Chemical Industry.

KeywordsAgronomy; Entomology
Year of Publication2002
JournalPest Management Science
Journal citation58 (3), pp. 243-247
Digital Object Identifier (DOI)doi:10.1002/ps.445
PubMed ID11975169
Open accessPublished as non-open access
Funder project or code437
514
ISSN1526498X
PublisherWiley

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