Mode of action and pesticidal activity of the natural product dunnione and of some analogues

A - Papers appearing in refereed journals

Khambay, B. P. S., Batty, D., Jewess, P. J., Bateman, G. L. and Hollomon, D. W. 2003. Mode of action and pesticidal activity of the natural product dunnione and of some analogues. Pest Management Science. 59 (2), pp. 174-182.

AuthorsKhambay, B. P. S., Batty, D., Jewess, P. J., Bateman, G. L. and Hollomon, D. W.
Abstract

This paper reports the investigation of the insecticidal and fungicidal activity of dunnione, a natural product obtained inadvertently as a by-product of a synthesis programme. Dunnione exhibits no insecticidal activity but has an unusually broad spectrum of antifungal activity. In vitro and in vivo (preventative) activities were comparable to those of several long-established fungicides (eg carbendazim). However, in whole-plant assays, its eradicant activity was unexpectedly low, probably due to poor dose-transfer from leaf surface to fungus. The level of residual activity appears to be influenced by the formulation. Finally, its potential as a lead structure was assessed, and several analogues synthesised which exhibited high activity in the in vitro assays. Mode-of-action studies revealed that dunnione exerts its action primarily through initiation of redox cycling. This contrasts to the activity of BTG 505, the biochemical/chemical precursor, which does not initiate redox cycling but instead exhibits both insecticidal and fungicidal activity by inhibiting mitochondrial Complex III.

KeywordsAgronomy; Entomology
Year of Publication2003
JournalPest Management Science
Journal citation59 (2), pp. 174-182
Digital Object Identifier (DOI)doi:10.1002/ps.632
PubMed ID12587871
Open accessPublished as non-open access
Funder project or code439
423
514
505
Output statusPublished
Publication dates
Online07 Jan 2003
Publication process dates
Accepted09 Sep 2002
Copyright licensePublisher copyright
PublisherWiley
ISSN1526-498X

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