A - Papers appearing in refereed journals
Khambay, B. P. S., Batty, D., Jewess, P. J., Bateman, G. L. and Hollomon, D. W. 2003. Mode of action and pesticidal activity of the natural product dunnione and of some analogues. Pest Management Science. 59 (2), pp. 174-182.
|Authors||Khambay, B. P. S., Batty, D., Jewess, P. J., Bateman, G. L. and Hollomon, D. W.|
This paper reports the investigation of the insecticidal and fungicidal activity of dunnione, a natural product obtained inadvertently as a by-product of a synthesis programme. Dunnione exhibits no insecticidal activity but has an unusually broad spectrum of antifungal activity. In vitro and in vivo (preventative) activities were comparable to those of several long-established fungicides (eg carbendazim). However, in whole-plant assays, its eradicant activity was unexpectedly low, probably due to poor dose-transfer from leaf surface to fungus. The level of residual activity appears to be influenced by the formulation. Finally, its potential as a lead structure was assessed, and several analogues synthesised which exhibited high activity in the in vitro assays. Mode-of-action studies revealed that dunnione exerts its action primarily through initiation of redox cycling. This contrasts to the activity of BTG 505, the biochemical/chemical precursor, which does not initiate redox cycling but instead exhibits both insecticidal and fungicidal activity by inhibiting mitochondrial Complex III.
|Year of Publication||2003|
|Journal||Pest Management Science|
|Journal citation||59 (2), pp. 174-182|
|Digital Object Identifier (DOI)||doi:10.1002/ps.632|
|Open access||Published as non-open access|
|Funder project or code||439|
|Online||07 Jan 2003|
|Publication process dates|
|Accepted||09 Sep 2002|
|Copyright license||Publisher copyright|
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