The role of cytochrome b 5 fusion desaturases in the synthesis of polyunsaturated fatty acids

A - Papers appearing in refereed journals

Napier, J. A., Michaelson, L. V. and Sayanova, O. V. 2003. The role of cytochrome b 5 fusion desaturases in the synthesis of polyunsaturated fatty acids. Prostaglandins, Leukotrienes and Essential Fatty Acids. 68 (2), pp. 135-143. https://doi.org/10.1016/S0952-3278(02)00263-6

AuthorsNapier, J. A., Michaelson, L. V. and Sayanova, O. V.
Abstract

The biosynthetic pathway of polyunsaturated fatty acids (PUFAs) has been the subject of much interest over the last few years. Significant progress has been made in the identification of the enzymes required for PUFA synthesis; in particular, the fatty acid desaturases which are central to this pathway have now all been identified. These "front-end" desaturases are all members of the cytochrome b(5) fusion desaturase superfamily, since they contain an N-terminal domain that is orthologous to the microsomal cytochrome b(5). Examination of the primary sequence relationships between the various PUFA-specific cytochrome b(5) fusion desaturases and related fusion enzymes allows inferences regarding the evolution of this important enzyme class. More importantly, this knowledge helps underpin our understanding of polyunsaturated fatty acid biosynthesis.

Year of Publication2003
JournalProstaglandins, Leukotrienes and Essential Fatty Acids
Journal citation68 (2), pp. 135-143
Digital Object Identifier (DOI)https://doi.org/10.1016/S0952-3278(02)00263-6
Open accessPublished as non-open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or code415
503
Project: 4156
Output statusPublished
PublisherElsevier
ISSN0952-3278

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