Molecular mechanisms correlated with reduced azole sensitivity in Mycosphaerella graminicola
C2 - Non-edited contributions to conferences
Cools, H. J. 2007. Molecular mechanisms correlated with reduced azole sensitivity in Mycosphaerella graminicola.
| Authors | Cools, H. J. |
|---|---|
| Type | C2 - Non-edited contributions to conferences |
| Year of Publication | 2007 |
| Journal | Phytopathology |
| Journal citation | 97 (Suppl.), p. S24 |
| Funder project or code | Centre for Sustainable Pest and Disease Management (PDM) |
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One step ahead? The evolution of fungicide resistance in Septoria leaf blotch of wheat
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Prothioconazole and prothioconazole-desthio activities against Candida albicans sterol 14-alpha-demethylase
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Detection and quantification of airborne inoculum of Pyrenopeziza brassicae in Polish and UK winter oilseed rape crops by real-time PCR assays
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Quantitative PCR analysis of abundance of airborne propagules of Leptosphaeria species in air samples from different regions of Poland
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Overexpression of the sterol 14α-demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotype.
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Risk assessment studies on succinate dehydrogenase inhibitors, the new weapons in the battle to control Septoria leaf blotch in wheat
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Functional characterisation of Mycosphaerella graminicola sterol 14alpha-demethylase variants resistant to azole fungicides
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Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola
A - Papers appearing in refereed journals
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Impact of recently emerged sterol 14alpha-demethylase (CYP51) variants of Mycosphaerella graminicola on azole fungicide sensitivity
A - Papers appearing in refereed journals
Cools, H. J., Mullins, J. G. L., Fraaije, B. A., Parker, J. E., Kelly, D. E., Lucas, J. A. and Kelly, S. L. 2011. Impact of recently emerged sterol 14alpha-demethylase (CYP51) variants of Mycosphaerella graminicola on azole fungicide sensitivity. Applied and Environmental Microbiology. 77, pp. 3830-3837. https://doi.org/10.1128/AEM.00027-11
Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals
A - Papers appearing in refereed journals
Parker, J. E., Warrilow, A. G. S., Cools, H. J., Martel, C. M., Nes, W. D., Fraaije, B. A., Lucas, J. A., Kelly, D. E. and Kelly, S. L. 2011. Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals. Applied and Environmental Microbiology. 77, pp. 1460-1465. https://doi.org/10.1128/AEM.01332-10
Investigating altered triazole sensitivity in Rhynchosporium secalis
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Hawkins, N. D., Cools, H. J., Shaw, M. W., Sierotzki, H. and Fraaije, B. A. 2010. Investigating altered triazole sensitivity in Rhynchosporium secalis. American Phytopathological Society (APS).
Succinate dehydrogenase inhibitor resistance risk assessment studies on Mycosphaerella graminicola the causal agent of septoria leaf blotch
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Bayon, C., Fraaije, M. W., Cools, H. J., Rogers, S. L., Lucas, J. A. and Fraaije, B. A. 2010. Succinate dehydrogenase inhibitor resistance risk assessment studies on Mycosphaerella graminicola the causal agent of septoria leaf blotch.
Prothioconazole binds to Mycosphaerella graminicola CYP51 by a different mechanism compared to other azole antifungals
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CYP51 paralogues and azole fungicide sensitivity in Rhynchosporium secalis
C2 - Non-edited contributions to conferences
Hawkins, N. J., Cools, H. J., Sierotzki, H., Shaw, M. and Fraaije, B. A. 2010. CYP51 paralogues and azole fungicide sensitivity in Rhynchosporium secalis. Abstracts 10th International Symposium on Cytochrome P450 Biodiversity and Biotechnology, Woods Hole, 3-7 October 2010 .
Recent evolution of P450 sterol 14a-demethylase (CYP51) of the wheat pathogen Mycosphaerella graminicola in response to selection by azole fungicides
C2 - Non-edited contributions to conferences
Cools, H. J. 2010. Recent evolution of P450 sterol 14a-demethylase (CYP51) of the wheat pathogen Mycosphaerella graminicola in response to selection by azole fungicides. Abstracts 10th International Symposium on Cytochrome P450 Biodiversity and Biotechnology, Woods Hole, 3-7 October 2010 .
Molecular mechanisms of altered fungicide sensitivity in Rhynchosporium secalis
C2 - Non-edited contributions to conferences
Hawkins, N. D., Cools, H. J., Shaw, M. W., Sierotzki, H. and Fraaije, B. A. 2010. Molecular mechanisms of altered fungicide sensitivity in Rhynchosporium secalis. Abstracts 16th International Reinhardsbrunn Symposium: Modern Fungicides and Antifungal Compounds, Friedrichroda, 25-29 April 2010 . pp. 50
Effects of DMI fungicides on selection of CYP51 variants in UK populations of Mycosphaerella graminicola
C2 - Non-edited contributions to conferences
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A - Papers appearing in refereed journals
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C2 - Non-edited contributions to conferences
Cools, H. J., Parker, J. E., Motteram, J., Kelly, D. E., Lucas, J. A., Rudd, J. J., Kelly, S. L. and Fraaije, B. A. 2010. Functional characterisation of Mycosphaerella graminicola sterol 14alpha-demethylase (MgCYP51) variants resistant to azole fungicides. Abstracts 16th International Reinhardsbrunn Symposium: Modern Fungicides and Antifungal Compounds, Friedrichroda, 25-29 April 2010 .
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C2 - Non-edited contributions to conferences
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Sterol content analysis suggests altered eburicol 14alpha-demethylase (CYP51) activity in isolates of Mycosphaerella graminicola adapted to azole fungicides
A - Papers appearing in refereed journals
Bean, T. P., Cools, H. J., Lucas, J. A., Hawkins, N. D., Ward, J. L., Shaw, M. W. and Fraaije, B. A. 2009. Sterol content analysis suggests altered eburicol 14alpha-demethylase (CYP51) activity in isolates of Mycosphaerella graminicola adapted to azole fungicides. FEMS Microbiology Letters. 296, pp. 266-273. https://doi.org/10.1111/j.1574-6968.2009.01645.x
Impact of proquinazid on appressorial development of the barley powdery mildew fungus Blumeria graminis f.sp hordei
A - Papers appearing in refereed journals
Gilbert, S. R., Cools, H. J., Fraaije, B. A., Bailey, A. M. and Lucas, J. A. 2009. Impact of proquinazid on appressorial development of the barley powdery mildew fungus Blumeria graminis f.sp hordei. Pesticide Biochemistry and Physiology. 94, pp. 127-132. https://doi.org/10.1016/j.pestbp.2009.04.011
Adaptation of Mycosphaerella graminicola populations to azole fungicides in the UK
C1 - Edited contributions to conferences/learned societies
Fraaije, B. A., Cools, H. J., Motteram, J., Gilbert, S. R., Kim, S-H. and Lucas, J. A. 2008. Adaptation of Mycosphaerella graminicola populations to azole fungicides in the UK. Deising, H. B., Lyr, H., Russell, P. E., Kuck, K. H., Gisi, U. and Dehne, H. W. (ed.) Modern Fungicides and Antifungal Compounds V: Proceedings 15th International Reinhardsbrunn Symposium on Modern Fungicides and Antifungal Compounds, 2007 . Deutsche Phytomedizinische Gesellschaft, Braunschweig. pp. 121-127
Expression of genes encoding efflux proteins in Mycosphaerella graminicola isolates with sensitive or reduced triazole sensitivity phenotypes
C1 - Edited contributions to conferences/learned societies
Bean, T. P., Cools, H. J., Lucas, J. A. and Fraaije, B. A. 2008. Expression of genes encoding efflux proteins in Mycosphaerella graminicola isolates with sensitive or reduced triazole sensitivity phenotypes. Deising, H. B., Lyr, H., Russell, P. E., Kuck, K. H., Gisi, U. and Dehne, H. W. (ed.) Modern Fungicides and Antifungal Compounds V: Proceedings 15th International Reinhardsbrunn Symposium on Modern Fungicides and Antifungal Compounds, 2007 . Deutsche Phytomedizinische Gesellschaft, Braunschweig. pp. 93-99
Quantitative measurements of CYP51 alterations in populations of Mycosphaerella graminicola using pyrosequencing
C2 - Non-edited contributions to conferences
Motteram, J., Cools, H. J., Gilbert, S. and Fraaije, B. A. 2008. Quantitative measurements of CYP51 alterations in populations of Mycosphaerella graminicola using pyrosequencing.
Demethylation inhibitor resistance in cereal pathogens and consequences of resistance management
C2 - Non-edited contributions to conferences
Fraaije, B. A., Cools, H. J., Motteram, J. and Lucas, J. A. 2008. Demethylation inhibitor resistance in cereal pathogens and consequences of resistance management.
Characterisation of mechanisms correlated with reduced azole sensitivity in Mycosphaerella graminicola
C2 - Non-edited contributions to conferences
Cools, H. J., Fraaije, B. A., Bean, T. P. and Lucas, J. A. 2008. Characterisation of mechanisms correlated with reduced azole sensitivity in Mycosphaerella graminicola.
Impact of mutations in the CYP51 gene of Mycosphaerella graminicola on azole fungicide sensitivity and intrinsic protein function
C2 - Non-edited contributions to conferences
Cools, H. J., Fraaije, B. A., Fernandez-Ortuno, D., Bean, T. P. and Lucas, J. A. 2008. Impact of mutations in the CYP51 gene of Mycosphaerella graminicola on azole fungicide sensitivity and intrinsic protein function. Abstracts 7th International Mycosphaerella and Stagonospora Symposium, Ascona, 18-22 August 2008 .
Controlling Septoria: can azole fungicides be relied upon?
G - Articles in popular magazines and other technical publications
Fraaije, B. A., Cools, H. J., Clark, B. and Lucas, J. A. 2008. Controlling Septoria: can azole fungicides be relied upon? RRA Newsletter. 26, p. 3.
Are azole fungicides losing ground against Septoria wheat disease? Resistance mechanisms in Mycosphaerella graminicola
A - Papers appearing in refereed journals
Cools, H. J. and Fraaije, B. A. 2008. Are azole fungicides losing ground against Septoria wheat disease? Resistance mechanisms in Mycosphaerella graminicola. Pest Management Science. 64 (7), pp. 681-684. https://doi.org/10.1002/ps.1568
Molecular mechanisms associated with altered azole sensitivity in Mycosphaerella graminicola
C1 - Edited contributions to conferences/learned societies
Cools, H. J., Bean, T. P., Motteram, J., Gilbert, S. R. and Fraaije, B. A. 2007. Molecular mechanisms associated with altered azole sensitivity in Mycosphaerella graminicola. Proceedings 16th International Plant Protection Congress, Glasgow, 15-18 October 2007 . pp. 406-407
Transcriptome profiling of the response of Mycosphaerella graminicola isolates to an azole fungicide using cDNA microarrays
A - Papers appearing in refereed journals
Cools, H. J., Fraaije, B. A., Bean, T. P., Antoniw, J. F. and Lucas, J. A. 2007. Transcriptome profiling of the response of Mycosphaerella graminicola isolates to an azole fungicide using cDNA microarrays. Molecular Plant Pathology. 8 (5), pp. 639-651. https://doi.org/10.1111/J.1364-3703.2007.00411.X
Sterol content analysis of Mycosphaerella graminicola isolates with reduced sensitivity to triazole fungicides
C2 - Non-edited contributions to conferences
Bean, T. P., Cools, H. J., Fraaije, B. A. and Lucas, J. A. 2007. Sterol content analysis of Mycosphaerella graminicola isolates with reduced sensitivity to triazole fungicides.
Comparison of Leptosphaeria biglobosa- induced and chemically induced systemic resistance to L. maculans in Brassica napus
A - Papers appearing in refereed journals
Liu, S-Y., Liu, R-H., Latunde-Dada, A. O., Cools, H. J., Foster, S. J., Huang, Y-J. and Fitt, B. D. L. 2007. Comparison of Leptosphaeria biglobosa- induced and chemically induced systemic resistance to L. maculans in Brassica napus. Chinese Science Bulletin. 52, pp. 1053-1062. https://doi.org/10.1007/s11434-007-0181-5
A novel substitution 1381V in the sterol 14alpha-demethylase (CYP51) of Mycosphaerella graminicola is differentially selected by azole fungicides
A - Papers appearing in refereed journals
Fraaije, B. A., Cools, H. J., Kim, S-H., Motteram, J., Clark, W. S. and Lucas, J. A. 2007. A novel substitution 1381V in the sterol 14alpha-demethylase (CYP51) of Mycosphaerella graminicola is differentially selected by azole fungicides. Molecular Plant Pathology. 8 (3), pp. 245-254. https://doi.org/10.1111/j.1364-3703.2007.00388.X
Methods to detect fungicide resistance: from broth dilution to real-time PCR
C1 - Edited contributions to conferences/learned societies
Fraaije, B. A. and Cools, H. J. 2006. Methods to detect fungicide resistance: from broth dilution to real-time PCR. Fungicide Resistance: Are We Winning the Battle but Losing the War? Aspects of Applied Biology 78 . pp. 11-15
Transcriptome profiling of the response of Mycosphaerella graminicola isolates to triazole fungicides using cDNA microarrays
C2 - Non-edited contributions to conferences
Cools, H. J., Antoniw, J. F. and Fraaije, B. A. 2006. Transcriptome profiling of the response of Mycosphaerella graminicola isolates to triazole fungicides using cDNA microarrays. Abstracts 11th IUPAC International Congress of Pesticide Chemistry, Kobe, 6-11 August 2006 . pp. 140
Transcriptome profiling of the response of Mycosphaerella graminicola isolates to triazole fungicides using cDNA microarrays
C2 - Non-edited contributions to conferences
Cools, H. J., Antoniw, J. F., Bean, T. P. and Fraaije, B. A. 2006. Transcriptome profiling of the response of Mycosphaerella graminicola isolates to triazole fungicides using cDNA microarrays. Abstracts 3rd COGEME Interest Group Meeting, Manchester, 7-8 November 2006 . pp. 28
Evolution of azole resistance mechanisms in UK populations of Mycosphaerella graminicola
C1 - Edited contributions to conferences/learned societies
Cools, H. J. and Fraaije, B. A. 2006. Evolution of azole resistance mechanisms in UK populations of Mycosphaerella graminicola. Fungicide Resistance: Are We Winning the Battle but Losing the War? Aspects of Applied Biology 78 . pp. 21-27
In planta expression analysis in Mycosphaerella graminicola of genes encoding efflux proteins
C2 - Non-edited contributions to conferences
Bean, T. P., Cools, H. J., Fraaije, B. A. and Lucas, J. A. 2006. In planta expression analysis in Mycosphaerella graminicola of genes encoding efflux proteins. Asbtracts APS CPS MSA Joint Meeting on Plant Pathology at the Biological Crossroads, Quebec, 29 July-2 August 2006 . pp. 11
Impact of changes in the target P450 CYP51 enzyme associated with altered triazole-sensitivity in fungal pathogens of cereal crops
A - Papers appearing in refereed journals
Cools, H. J., Fraaije, B. A., Kim, S. H. and Lucas, J. A. 2006. Impact of changes in the target P450 CYP51 enzyme associated with altered triazole-sensitivity in fungal pathogens of cereal crops. Biochemical Society Transactions. 34 (6), pp. 1219-1222. https://doi.org/10.1042/BST0341219
Exploring appressorial formation in the cereal biotroph powdery mildew
C2 - Non-edited contributions to conferences
Gilbert, S. R., Fraaije, B. A., Bailey, A., Cools, H. J. and Lucas, J. A. 2006. Exploring appressorial formation in the cereal biotroph powdery mildew. Abstracts 8th European Conference on Fungal Genetics, Vienna, 8-11 April 2006 . pp. 165
Testing an experimental fungicide for in vitro activity against Mycosphaerella graminicola (anamorph Septoria tritici ) (Confidential report for Cropsolution Inc)
D1 - Technical reports: non-confidential
Lucas, J. A., Bean, T., Cools, H. J. and Fraaije, B. A. 2005. Testing an experimental fungicide for in vitro activity against Mycosphaerella graminicola (anamorph Septoria tritici ) (Confidential report for Cropsolution Inc).
Exploring appressorial formation in the biotrophic cereal fungus powdery mildew
C2 - Non-edited contributions to conferences
Gilbert, S., Cools, H. J., Fraaije, B. A., Bailey, A. and Lucas, J. A. 2005. Exploring appressorial formation in the biotrophic cereal fungus powdery mildew. Abstracts 23rd Fungal Genetics Conference, Asilomar, 15-20 March 2005 . pp. 177
The role of ascospores in further spread of QoI-resistant cytochrome b alleles (G143A) in field populations of Mycosphaerella graminicola
A - Papers appearing in refereed journals
Fraaije, B. A., Cools, H. J., Fountaine, J., Lovell, D. J., Motteram, J., West, J. S. and Lucas, J. A. 2005. The role of ascospores in further spread of QoI-resistant cytochrome b alleles (G143A) in field populations of Mycosphaerella graminicola. Phytopathology. 95 (8), pp. 933-941. https://doi.org/10.1094/PHYTO-95-0933
Molecular examination of Septoria tritici isolates with reduced sensitivities to triazoles
C1 - Edited contributions to conferences/learned societies
Cools, H. J., Fraaije, B. A. and Lucas, J. A. 2005. Molecular examination of Septoria tritici isolates with reduced sensitivities to triazoles. Dehne, H-W., Lyr, H., Russell, P. E., Kuck, K. H. and Gisi, U. (ed.) Modern Fungicides and Antifungal Compounds IV: Proceedings of the 14th International Reinhardsbrunn Symposium, Friedrichroda, 25-29 April 2004 . British Crop Protection Council (BCPC). pp. 103-114
Molecular mechanisms correlated with changes in triazole sensitivity in isolates of Mycosphaerella graminicola
C1 - Edited contributions to conferences/learned societies
Cools, H. J., Fraaije, B. A. and Lucas, J. A. 2005. Molecular mechanisms correlated with changes in triazole sensitivity in isolates of Mycosphaerella graminicola. Proceedings BCPC International Congress - Crop Science and Technology, Glasgow, 31 October-2 November 2005 . pp. 267-274
Using cDNA microarrays to profile the response of Mycosphaerella graminicola to triazole fungicides
C2 - Non-edited contributions to conferences
Cools, H. J., Fraaije, B. A., Keon, J. P. R., Antoniw, J. F. and Lucas, J. A. 2005. Using cDNA microarrays to profile the response of Mycosphaerella graminicola to triazole fungicides. Abstracts COGEME Interest Group Meeting, Manchester, 8-9 November 2005 .
Leptosphaeria biglobosa can induce higher resistance of Brassica napus to Phoma stem canker by triggering earlier JA/ET pathway and stronger SA pathway both locally and systematically
C2 - Non-edited contributions to conferences
Liu, R., Liu, S., Fitt, B. D. L., Cools, H. J., Latunde-Dada, A. O., Huang, Y-J., Li, Z. and Lucas, J. A. 2004. Leptosphaeria biglobosa can induce higher resistance of Brassica napus to Phoma stem canker by triggering earlier JA/ET pathway and stronger SA pathway both locally and systematically. Abstracts Discovery, Development and Delivery in Plant Pathology: 7th Conference of the European Foundation for Plant Pathology and BSPP Presidential Meeting 2004, Aberdeen, 5-10 September 2004 . pp. 38
Molecular mechanisms conferring reduced sensitivities to triazoles in UK isolates of Septoria tritici
C2 - Non-edited contributions to conferences
Cools, H. J., Fraaije, B. A. and Lucas, J. A. 2004. Molecular mechanisms conferring reduced sensitivities to triazoles in UK isolates of Septoria tritici.
Menadione sodium bisulphite: a novel plant defence activator which enhances local and systemic resistance to infection by Leptosphaeria maculans in oilseed rape
A - Papers appearing in refereed journals
Borges, A. A., Cools, H. J. and Lucas, J. A. 2003. Menadione sodium bisulphite: a novel plant defence activator which enhances local and systemic resistance to infection by Leptosphaeria maculans in oilseed rape. Plant Pathology. 52 (4), pp. 429-436. https://doi.org/10.1046/j.1365-3059.2003.00877.x
Pre-treatment of cucumber plants with acibenzolar-S-methyl systemically primes a phenylalanine ammonia lyase gene (PAL1 ) for enhanced expression upon attack with a pathogenic fungus
A - Papers appearing in refereed journals
Cools, H. J. and Ishii, H. 2002. Pre-treatment of cucumber plants with acibenzolar-S-methyl systemically primes a phenylalanine ammonia lyase gene (PAL1 ) for enhanced expression upon attack with a pathogenic fungus. Physiological and Molecular Plant Pathology. 61, pp. 273-280.
Cloning and sequence analysis of the eburicol 14alpha-demethylase encoding gene (CYP51 ) from the Japanese pear scab fungus Venturia nashicola
A - Papers appearing in refereed journals
Cools, H. J., Ishii, H., Butters, J. A. and Hollomon, D. W. 2002. Cloning and sequence analysis of the eburicol 14alpha-demethylase encoding gene (CYP51 ) from the Japanese pear scab fungus Venturia nashicola. Journal of Phytopathology. 150 (42986), pp. 444-450. https://doi.org/10.1046/j.1439-0434.2002.00776.x
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