Knockdown resistance to DDT and pyrethroids: from target-site mutations to molecular modelling

A - Papers appearing in refereed journals

Davies, T. G. E., O'Reilly, A. O., Field, L. M., Wallace, B. A. and Williamson, M. S. 2008. Knockdown resistance to DDT and pyrethroids: from target-site mutations to molecular modelling. Pest Management Science. 64 (11), pp. 1126-1130.

AuthorsDavies, T. G. E., O'Reilly, A. O., Field, L. M., Wallace, B. A. and Williamson, M. S.
Abstract

Naturally derived insecticides such as pyrethrum and man-made insecticides such as DDT and the synthetic pyrethroids act on the voltage-gated sodium channel proteins found in insect nerve-cell membranes. The correct functioning of these channels is essential for the normal transmission of nerve impulses, and this process is disrupted by binding of the insecticides, leading to paralysis and eventual death. Some insect pest populations have evolved modifications of the sodium channel protein that inhibit the binding of the insecticide and result in the insect developing resistance. This perspective outlines the current understanding of the molecular processes underlying target-site resistance to these insecticides (termed kdr and super-kdr), and how this knowledge may in future contribute to the design of novel insecticidal compounds. (c) 2008 Society of Chemical Industry

KeywordsAgronomy; Entomology
Year of Publication2008
JournalPest Management Science
Journal citation64 (11), pp. 1126-1130
Digital Object Identifier (DOI)doi:10.1002/ps.1617
PubMed ID18561309
Open accessPublished as non-open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codePDM
ISSN1526498X
PublisherWiley
Grant IDBB/F009143/1

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