An analogue of piperonyl butoxide facilitates the characterisation of metabolic resistance

A - Papers appearing in refereed journals

Moores, G. D., Philippou, D., Borzatta, V., Trincia, P., Jewess, P., Gunning, R. and Bingham, G. 2009. An analogue of piperonyl butoxide facilitates the characterisation of metabolic resistance. Pest Management Science. 65 (2), pp. 150-154.

AuthorsMoores, G. D., Philippou, D., Borzatta, V., Trincia, P., Jewess, P., Gunning, R. and Bingham, G.
Abstract

BACKGROUND: Previous work has demonstrated that piperonyl butoxide (PBO) not only inhibits microsomal oxidases but also resistance-associated esterases. The ability to inhibit both major metabolic resistance enzymes makes it an ideal synergist to enhance xenobiotics but negates the ability to differentiate which enzyme group is responsible for conferring resistance. RESULTS: This study examines an analogue that retains the ability to inhibit esterases but is restricted in its ability to act on microsomal oxidases, thus allowing an informed decision on resistance enzymes to be made when used in conjunction with the parent molecule. CONCLUSION: Using examples of resistant insects with well-characterised resistance mechanisms, a combination of PBO and analogue allows identification of the metabolic mechanism responsible for conferring resistance. The relative potency of PBO as both an esterase inhibitor and an oxidase inhibitor is also discussed. (C) 2008 Society of Chemical Industry

KeywordsAgronomy; Entomology
Year of Publication2009
JournalPest Management Science
Journal citation65 (2), pp. 150-154
Digital Object Identifier (DOI)doi:10.1002/ps.1661
PubMed ID18951417
Open accessPublished as non-open access
FunderEndura SpA, Italy
Biotechnology and Biological Sciences Research Council
Funder project or codeCentre for Sustainable Pest and Disease Management (PDM)
ISSN1526498X
PublisherWiley

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