Novel olfactory ligands via terpene synthases

A - Papers appearing in refereed journals

Touchet, S., Chamberlain, K., Woodcock, C. M., Miller, D. J., Birkett, M. A., Pickett, J. A. and Allemann, R. K. 2015. Novel olfactory ligands via terpene synthases. Chemical Communications. 51 (35), pp. 7550-7553.

AuthorsTouchet, S., Chamberlain, K., Woodcock, C. M., Miller, D. J., Birkett, M. A., Pickett, J. A. and Allemann, R. K.
Abstract

A synthetic biology approach to the rational design of analogues of olfactory ligands by providing unnatural substrates for the enzyme synthesising (S)-germacrene D, an olfactory ligand acting as a plant derived insect repellent, to produce novel ligands is described as a viable alternative to largely unsuccessful ligand docking studies. (S)-14,15-Dimethylgermacrene D shows an unexpected reversal in behavioural activity.

KeywordsRRES175; 175_Biochemistry
Year of Publication2015
JournalChemical Communications
Journal citation51 (35), pp. 7550-7553
Digital Object Identifier (DOI)doi:10.1039/c5cc01814e
Open accessPublished as ‘gold’ (paid) open access
Funder project or codeDelivering Sustainable Systems (SS) [ISPG]
Output statusPublished
Publication dates
Online07 Apr 2015
Publication process dates
Accepted30 Mar 2015
Copyright licenseCC BY
ISSN1359-7345
PublisherRoyal Society of Chemistry (RSC)

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