Proposal for a unified nomenclature for target-site mutations associated with resistance to fungicides.

A - Papers appearing in refereed journals

Mair, W., Lopez-Ruiz, F., Stammler, G ., Clark, W., Burnett, F., Hollomon, D., Ishii, H., Thind, T. S., Brown, J. K., Fraaije, B. A., Cools, H. J., Shaw, M., Fillinger, S., Walker, A. S., Mellado, E., Schnabel, G., Mehl, A. and Oliver, R. P. 2016. Proposal for a unified nomenclature for target-site mutations associated with resistance to fungicides. Pest Management Science. 72 (8), pp. 1449-1459.

AuthorsMair, W., Lopez-Ruiz, F., Stammler, G ., Clark, W., Burnett, F., Hollomon, D., Ishii, H., Thind, T. S., Brown, J. K., Fraaije, B. A., Cools, H. J., Shaw, M., Fillinger, S., Walker, A. S., Mellado, E., Schnabel, G., Mehl, A. and Oliver, R. P.
Abstract

Evolved resistance to fungicides is a major problem limiting our ability to control agricultural, medical and veterinary pathogens and is frequently associated with substitutions in the amino acid sequence of the target protein. The convention for describing amino acid substitutions is to cite the wild-type amino acid, the codon number and the new amino acid, using the one-letter amino acid code. It has frequently been observed that orthologous amino acid mutations have been selected in different species by fungicides from the same mode of action class, but the amino acids have different numbers. These differences in numbering arise from the different lengths of the proteins in each species. The purpose of the present paper is to propose a system for unifying the labelling of amino acids in fungicide target proteins. To do this we have produced alignments between fungicide target proteins of relevant species fitted to a well-studied archetype' species. Orthologous amino acids in all species are then assigned numerical labels' based on the position of the amino acid in the archetype protein. (c) 2016 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

KeywordsAgronomy; Entomology
Year of Publication2016
JournalPest Management Science
Journal citation72 (8), pp. 1449-1459
Digital Object Identifier (DOI)doi:10.1002/ps.4301
PubMed ID27148866
Open accessPublished as ‘gold’ (paid) open access
Funder project or codeDelivering Sustainable Systems (SS) [ISPG]
ISSN1526498X
PublisherWiley

Permalink - https://repository.rothamsted.ac.uk/item/8v261/proposal-for-a-unified-nomenclature-for-target-site-mutations-associated-with-resistance-to-fungicides

3 total views
0 total downloads
0 views this month
0 downloads this month