Biochemical evaluation of interactions between synergistic molecules and phase I enzymes involved in insecticide resistance in B- and Q-type Bemisia tabaci (Hemiptera: Aleyrodidae)

A - Papers appearing in refereed journals

Panini, M., Tozzi, F., Zimmer, C. T., Bass, C., Field, L. M., Borzatta, V., Mazzoni, E. and Moores, G. D. 2017. Biochemical evaluation of interactions between synergistic molecules and phase I enzymes involved in insecticide resistance in B- and Q-type Bemisia tabaci (Hemiptera: Aleyrodidae). Pest Management Science. 73 (9), pp. 1873-1882.

AuthorsPanini, M., Tozzi, F., Zimmer, C. T., Bass, C., Field, L. M., Borzatta, V., Mazzoni, E. and Moores, G. D.
Abstract

BACKGROUND
Metabolic resistance is an important consideration in the whitefly Bemisia tabaci, where an esterase‐based mechanism has been attributed to pyrethroid resistance and over‐expression of the cytochrome P450, CYP6CM1, has been correlated to resistance to imidacloprid and other neonicotinoids.

RESULTS
In vitro interactions between putative synergists and CYP6CM1, B and Q‐type esterases were investigated, and structure–activity relationship analyses allowed the identification of chemical structures capable of acting as inhibitors of esterase and oxidase activities. Specifically, methylenedioxyphenyl (MDP) moieties with a polyether chain were preferable for optimum inhibition of B‐type esterase, whilst corresponding dihydrobenzofuran structures were potent for the Q‐esterase variation. Potent inhibition of CYP6CM1 resulted from structures which contained an alkynyl chain with a terminal methyl group.

CONCLUSIONS
Synergist candidates could be considered for field control of B. tabaci, especially to abrogate neonicotinoid resistance. © 2017 Society of Chemical Industry

KeywordsSAR; synergist; P450s; piperonyl butoxide; esterase; Bemisia tabaci
Year of Publication2017
JournalPest Management Science
Journal citation73 (9), pp. 1873-1882
Digital Object Identifier (DOI)doi:10.1002/ps.4553
Open accessPublished as non-open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeBBSRC Strategic Programme in Smart Crop Protection
Publisher's version
Output statusPublished
Publication dates
Online14 Mar 2017
Publication process dates
Accepted13 Feb 2017
PublisherJohn Wiley & Sons, Ltd
Wiley
Copyright licensePublisher copyright
ISSN1526-498X

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