Stress and sexual reproduction affect the dynamics of the wheat pathogen effector AvrStb6 and strobilurin resistance

A - Papers appearing in refereed journals

Kema, G. H. J., Mirzadi Gohari, A., Aouini, L., Gibriel, H. A. Y., Ware, S. B., Van Den Bosch, F., Manning-Smith, R., Alonso Chavez, V., Helps, J., Ben M’Barek, S., Mehrabi, R., Diaz-Trujillo, C., Zamani, E., Schouten, H. J., Van Der Lee, T. A. J., Waalwijk, C., de Waard, M. A., de Wit, P. J. G. M., Verstappen, E. C. P., Thomma, B. P. H. J., Meijer, H. J. G. and Seidl, M.l F. 2018. Stress and sexual reproduction affect the dynamics of the wheat pathogen effector AvrStb6 and strobilurin resistance. Nature Genetics. 50 (3), pp. 375-380.

AuthorsKema, G. H. J., Mirzadi Gohari, A., Aouini, L., Gibriel, H. A. Y., Ware, S. B., Van Den Bosch, F., Manning-Smith, R., Alonso Chavez, V., Helps, J., Ben M’Barek, S., Mehrabi, R., Diaz-Trujillo, C., Zamani, E., Schouten, H. J., Van Der Lee, T. A. J., Waalwijk, C., de Waard, M. A., de Wit, P. J. G. M., Verstappen, E. C. P., Thomma, B. P. H. J., Meijer, H. J. G. and Seidl, M.l F.
Abstract

Host resistance and fungicide treatments are cornerstones of plant-disease control. Here, we show that these treatments allow sex and modulate parenthood in the fungal wheat pathogen Zymoseptoria tritici. We demonstrate that the Z. tritici–wheat interaction complies with the gene-for-gene model by identifying the effector AvrStb6, which is recognized by the wheat resistance protein Stb6. Recognition triggers host resistance, thus implying removal of avirulent strains from pathogen populations. However, Z. tritici crosses on wheat show that sex occurs even with an avirulent parent, and avirulence alleles are thereby retained in subsequent populations. Crossing fungicide-sensitive and fungicide-resistant isolates under fungicide pressure results in a rapid increase in resistance-allele frequency. Isolates under selection always act as male donors, and thus disease control modulates parenthood. Modeling these observations for agricultural and natural environments reveals extended durability of host resistance and rapid emergence of fungicide resistance. Therefore, fungal sex has major implications for disease control.

Year of Publication2018
JournalNature Genetics
Journal citation50 (3), pp. 375-380
Digital Object Identifier (DOI)doi:10.1038/s41588-018-0052-9
Open accessPublished as bronze (free) open access
Publisher's version
Output statusPublished
Publication dates
Online12 Feb 2018
Copyright licensePublisher copyright
ISSN1061-4036
PublisherNature Publishing Group

Permalink - https://repository.rothamsted.ac.uk/item/8w277/stress-and-sexual-reproduction-affect-the-dynamics-of-the-wheat-pathogen-effector-avrstb6-and-strobilurin-resistance

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