Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 8822662 B2)
H1 - Patents granted
Senger, T., Bauer J. and Napier, J. A. 2014. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 8822662 B2). US 8822662 B2
| Authors | Senger, T., Bauer J. and Napier, J. A. |
|---|---|
| Type | H1 - Patents granted |
| Patent applicant | Senger Toralf |
| Bauer Jorg | |
| Napier Johnathan A | |
| Basf Plant Science Co Gmbh | |
| Patent ID | US 8822662 B2 |
| 100-929-481-636-366 | |
| Abstract | The present invention relates to polynucleotides from Cochliobolus heterostrophus C5, Cyanothece sp. CCY0110, Mycocentrospora acerina and Hyaloperonospora parasitica, which code for desaturases and which can be employed for the recombinant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotides according to the invention, and to the polypeptides encoded by the polynucleotides. The invention furthermore relates to antibodies against the polypeptides according to the invention. Finally, the invention also relates to production processes for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions and to their use as drugs, cosmetics, foodstuffs, feedstuffs, preferably fish food, or food supplements. |
| Year of Publication | 2014 |
| Funder project or code | Designing oilseeds for nutrition and health |
| Open access | Published as non-open access |
| File |
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Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2016/0272951 A1)
H2 - Patents applied for
Senger, T., Marty, L., Stymne S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2016. Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2016/0272951 A1) . US 2016/0272951 A1
Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 9388437 B2)
H1 - Patents granted
Napier, J. A., Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2016. Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 9388437 B2) . US 9388437 B2 182-807-288-915-40X
The Zinc-Finger Protein SOP1 Is Required for a Subset of the Nuclear Exosome Functions in Arabidopsis
A - Papers appearing in refereed journals
Hematy, K., Bellec, Y., Podicheti, R., Bouteiller, N., Anne, P., Morineau, C., Haslam, R. P., Beaudoin, F., Napier, J. A., Mockaitis, K., Gagliardi, D., Vaucheret, H., Lange, H. and Faure, J. D. 2016. The Zinc-Finger Protein SOP1 Is Required for a Subset of the Nuclear Exosome Functions in Arabidopsis. PLOS Genetics. 12 (2), p. e1005817. https://doi.org/10.1371/journal.pgen.1005817
Heterotrophic Production of Omega-3 Long-Chain Polyunsaturated Fatty Acids by Trophically Converted Marine Diatom Phaeodactylum tricornutum
A - Papers appearing in refereed journals
Hamilton, M. L., Powers, S. J., Napier, J. A. and Sayanova, O. V. 2016. Heterotrophic Production of Omega-3 Long-Chain Polyunsaturated Fatty Acids by Trophically Converted Marine Diatom Phaeodactylum tricornutum. Marine Drugs. 14 (3), p. 53. https://doi.org/10.3390/md14030053
Nutritional Evaluation of an EPA-DHA Oil from Transgenic Camelina sativa in Feeds for Post-Smolt Atlantic Salmon (Salmo salar L.)
A - Papers appearing in refereed journals
Betancor, M. B., Sprague, M., Sayanova, O. V., Usher, S., Metochis, C., Campbell, P. J., Napier, J. A. and Tocher, D. R. 2016. Nutritional Evaluation of an EPA-DHA Oil from Transgenic Camelina sativa in Feeds for Post-Smolt Atlantic Salmon (Salmo salar L.). PLOS ONE. 11 (7). https://doi.org/10.1371/journal.pone.0159934
Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.)
A - Papers appearing in refereed journals
Betancor, M. B., Sprague, M., Montero, D., Usher, S., Sayanova, O. V., Campbell, P. J., Napier, J. A., Caballero, M. J., Izquierdo, M. and Tocher, D. R. 2016. Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.). Lipids. 51 (10), pp. 1171-1191. https://doi.org/10.1007/s11745-016-4191-4
A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice
A - Papers appearing in refereed journals
Tejera, N., Vauzour, D., Betancor, M. B., Sayanova, O. V., Usher, S., Cochard, M., Rigby, N., Ruiz-Lopez, N., Menoyo, D., Tocher, D. R., Napier, J. A. and Minihane, A. M. 2016. A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice. Journal Of Nutrition. 146 (2), pp. 227-235. https://doi.org/10.3945/jn.115.223941
Intragenus competition between coccolithoviruses: an insight on how a select few can come to dominate many
A - Papers appearing in refereed journals
Nissimov, J. I., Napier, J. A., Allen, M. J. and Kimmance, S. A. 2016. Intragenus competition between coccolithoviruses: an insight on how a select few can come to dominate many. Environmental Microbiology. 18 (1), pp. 133-145. https://doi.org/10.1111/1462-2920.12902
Dual Fatty Acid Elongase Complex Interactions in Arabidopsis
A - Papers appearing in refereed journals
Morineau, C., Gissot, L., Bellec, Y., Hematy, K., Tellier, F., Renne, C., Haslam, R. P., Beaudoin, F., Napier, J. A. and Faure, J. D. 2016. Dual Fatty Acid Elongase Complex Interactions in Arabidopsis. PLOS ONE. 11 (9), p. 20. https://doi.org/10.1371/journal.pone.0160631
Sunflower HaGPAT9-1 is the predominant GPAT during seed development
A - Papers appearing in refereed journals
Paya-Milans, M., Aznar-Moreno, J. A., Balbuena, T. S., Haslam, R. P., Gidda, S. K., Perez-Hormaeche, J., Mullen, R. T., Thelen, J. J., Napier, J. A., Salas, J. J., Garces, R., Martinez-Force, E. and Venegas-Caleron, M. 2016. Sunflower HaGPAT9-1 is the predominant GPAT during seed development. Plant Science. 252 (November), pp. 42-52. https://doi.org/10.1016/j.plantsci.2016.07.002
Metabolome analysis reveals betaine lipids as major source for triglyceride formation, and the accumulation of sedoheptulose during nitrogen-starvation of Phaeodactylum tricornutum
A - Papers appearing in refereed journals
Popko, J., Herrfurth, C., Feussner, K., Ischebeck, T., Iven, T., Haslam, R. P., Hamilton, M. L., Sayanova, O. V., Napier, J. A., Khozin-Goldberg, I. and Feussner, I. 2016. Metabolome analysis reveals betaine lipids as major source for triglyceride formation, and the accumulation of sedoheptulose during nitrogen-starvation of Phaeodactylum tricornutum. PLOS ONE. 11 (10), p. e0164674. https://doi.org/10.1371/journal.pone.0164673
Plant sphingolipids: their importance in cellular organization and adaption
A - Papers appearing in refereed journals
Michaelson, L. V., Napier, J. A., Molino, D. and Faure, J-D. 2016. Plant sphingolipids: their importance in cellular organization and adaption. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1861 (9 Part B), pp. 1329-1335. https://doi.org/10.1016/j.bbalip.2016.04.003
Synthetic redesign of plant lipid metabolism
A - Papers appearing in refereed journals
Haslam, R. P., Sayanova, O. V., Kim, H. J., Cahoon, E. B. and Napier, J. A. 2016. Synthetic redesign of plant lipid metabolism. The Plant Journal. 87 (1), pp. 76-86. https://doi.org/10.1111/tpj.13172
Recombinant Organisms (Patent US 2015/0275243 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V., Hamilton, M. L. and Vaezi, R. 2015. Recombinant Organisms (Patent US 2015/0275243 A1). US 2015/0275243 A1
Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 9139854 B2)
H1 - Patents granted
Senger, T., Bauer, J. and Napier, J. A. 2015. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 9139854 B2) . US 9139854 B2
Recombinant Organisms (Patent EP 2904091 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V., Hamilton, M. L. and Vaezi, R. 2015. Recombinant Organisms (Patent EP 2904091 A1). EP 2904091 A1
Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent US 2015/0216828 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V., Ruiz-Lopez, N. and Haslam, R. P. 2015. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent US 2015/0216828 A1) . US 2015/0216828 A1
Fatty Acid Elongation Components And Uses Thereof (Patent US 8993841 B2 )
H1 - Patents granted
Napier, J. A., Sayanova, O. V. and Beaudoin, F. 2015. Fatty Acid Elongation Components And Uses Thereof (Patent US 8993841 B2 ) . US 8993841 B2
Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2281051 B1)
H1 - Patents granted
Bauer, J., Napier, J. A. and Sayanova, O. V. 2015. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2281051 B1) . EP 2281051 B1
Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent EP 2836599 A1)
H2 - Patents applied for
Napier, J. A., Ruiz-Lopez, N. and Haslam, R. P. 2015. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent EP 2836599 A1) . EP 2836599 A1
Metabolic engineering of diatoms for the enhanced production of high value lipids
C2 - Non-edited contributions to conferences
Hamilton, M. L., Haslam, R. P., Sayanova, O. V. and Napier, J. A. 2015. Metabolic engineering of diatoms for the enhanced production of high value lipids. Sixth European Phycological Congress 23-28 August 2015 London UK. Taylor & Francis. https://doi.org/10.1080/09670262.2015.1069489
Sphingolipid metabolism is strikingly different between pollen and leaf in Arabidopsis as revealed by compositional and gene expression profiling
A - Papers appearing in refereed journals
Luttgeharm, K. D., Kimberlin, A. N., Cahoon, R. E., Cerny, R. L., Napier, J. A., Markham, J. E. and Cahoon, E. B. 2015. Sphingolipid metabolism is strikingly different between pollen and leaf in Arabidopsis as revealed by compositional and gene expression profiling. Phytochemistry. 115, pp. 121-129. https://doi.org/10.1016/j.phytochem.2015.02.019
Towards the industrial production of omega-3 long chain polyunsaturated fatty acids from a genetically modified diatom Phaeodactylum tricornutum
A - Papers appearing in refereed journals
Hamilton, M. L., Warwick, J., Terry, A., Allen, M. J., Napier, J. A. and Sayanova, O. V. 2015. Towards the industrial production of omega-3 long chain polyunsaturated fatty acids from a genetically modified diatom Phaeodactylum tricornutum. PLOS ONE. 10, p. e0144054. https://doi.org/10.1371/journal.pone.0144054
ECERIFERUM2-LIKE proteins have unique biochemical and physiological functions in very-long-chain fatty acid elongation
A - Papers appearing in refereed journals
Haslam, T. M., Haslam, R. P., Thoraval, D., Pascal, S., Delude, C., Domergue, F., Fernandez, A. M., Beaudoin, F., Napier, J. A., Kunst, L. and Joubes, J. 2015. ECERIFERUM2-LIKE proteins have unique biochemical and physiological functions in very-long-chain fatty acid elongation. Plant Physiology. 167, pp. 682-692. https://doi.org/10.1104/pp.114.253195
Field trial evaluation of the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Camelina sativa: making fish oil substitutes in plants
A - Papers appearing in refereed journals
Usher, S. L., Haslam, R. P., Ruiz-Lopez, N., Sayanova, O. V. and Napier, J. A. 2015. Field trial evaluation of the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Camelina sativa: making fish oil substitutes in plants. Metabolic Engineering Communications. 2, pp. 93-98. https://doi.org/10.1016/j.meteno.2015.04.002
The first crop plant genetically engineered to release an insect pheromone for defence
A - Papers appearing in refereed journals
Bruce, T. J. A., Aradottir, G. I., Smart, L. E., Martin, J. L., Caulfield, J. C., Doherty, A., Sparks, C. A., Woodcock, C. M., Birkett, M. A., Napier, J. A., Jones, H. D. and Pickett, J. A. 2015. The first crop plant genetically engineered to release an insect pheromone for defence. Scientific Reports. 5, p. 11183. https://doi.org/10.1038/srep11183
Transgenic plants as a sustainable, terrestrial source of fish oils
A - Papers appearing in refereed journals
Napier, J. A., Usher, S. L., Haslam, R. P., Ruiz-Lopez, N. and Sayanova, O. V. 2015. Transgenic plants as a sustainable, terrestrial source of fish oils. European Journal Of Lipid Science And Technology. 117 (9), pp. 1317-1324. https://doi.org/10.1002/ejlt.201400452
An alternative pathway for the effective production of the omega-3 long-chain polyunsaturates EPA and ETA in transgenic oilseeds
A - Papers appearing in refereed journals
Ruiz-Lopez, N., Haslam, R. P., Usher, S. L., Napier, J. A. and Sayanova, O. V. 2015. An alternative pathway for the effective production of the omega-3 long-chain polyunsaturates EPA and ETA in transgenic oilseeds. Plant Biotechnology Journal. 13 (9), pp. 1264-1275. https://doi.org/10.1111/pbi.12328
A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish
A - Papers appearing in refereed journals
Betancor, M. B., Sprague, M., Usher, S. L., Sayanova, O. V., Campbell, P. J., Napier, J. A. and Tocher, D. R. 2015. A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish. Scientific Reports. 5, p. 8104. https://doi.org/10.1038/srep08104
Evaluation of a high-EPA oil from transgenic Camelina sativa in feeds for Atlantic salmon (Salmo salar L.): effects on tissue fatty acid composition, histology and gene expression
A - Papers appearing in refereed journals
Betancor, M. B., Sprague, M., Sayanova, O. V., Usher, S. L., Campbell, P. J., Napier, J. A., Caballero, M. J. and Tocher, D. R. 2015. Evaluation of a high-EPA oil from transgenic Camelina sativa in feeds for Atlantic salmon (Salmo salar L.): effects on tissue fatty acid composition, histology and gene expression. Aquaculture. 444, pp. 1-12. https://doi.org/10.1016/j.aquaculture.2015.03.020
Molecular characterization of two isoforms of a farnesyl pyrophosphate synthase gene in wheat and their roles in sesquiterpene synthesis and inducible defence against aphid infestation
A - Papers appearing in refereed journals
Zhang, Y., Li, Z-X., Yu, X-D., Fan, J., Pickett, J. A., Jones, H. D., Zhou, J-J., Birkett, M. A., Caulfield, J., Napier, J. A., Zhao, G-Y., Cheng, X-G., Shi, Y., Bruce, T. J. A. and Xia, L-Q. 2015. Molecular characterization of two isoforms of a farnesyl pyrophosphate synthase gene in wheat and their roles in sesquiterpene synthesis and inducible defence against aphid infestation. New Phytologist. 206 (3), pp. 1101-1115. https://doi.org/10.1111/nph.13302
Modifying the lipid content and composition of plant seeds: engineering the production of LC-PUFA
A - Papers appearing in refereed journals
Ruiz-Lopez, N., Usher, S. L., Sayanova, O. V., Napier, J. A. and Haslam, R. P. 2015. Modifying the lipid content and composition of plant seeds: engineering the production of LC-PUFA. Applied Microbiology and Biotechnology. 99 (1), pp. 143-154. https://doi.org/10.1007/s00253-014-6217-2
Gluten quality of bread wheat is associated with activity of RabD GTPases
A - Papers appearing in refereed journals
Tyler, A. M., Bhandari, D. G., Poole, M., Napier, J. A., Jones, H. D., Lu, C. and Lycett, G. W. 2015. Gluten quality of bread wheat is associated with activity of RabD GTPases. Plant Biotechnology Journal. 13 (2), pp. 163-176. https://doi.org/10.1111/pbi.12231
Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 2014/0335579 A1)
H2 - Patents applied for
Senger, T., Bauer, J. and Napier, J. A. 2014. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 2014/0335579 A1) . US 2014/0335579 A1
Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent EP 1576166 B1)
H1 - Patents granted
Napier, J. A., Sayanova, O. V., Lazarus, C. M., Qi, B, Heinz, E., Zank, T. and Zahringer, U. 2014. Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent EP 1576166 B1). EP 1576166 B1
Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 8785727 B2)
H1 - Patents granted
Bauer, J., Napier, J. A. and Sayanova, O. V. 2014. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 8785727 B2). US 8785727 B2
Recombinant Organisms (Patent WO 2014/053821 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V., Hamilton, M. L. and Vaezi, R. 2014. Recombinant Organisms (Patent WO 2014/053821 A1) . WO 2014/053821 A1
Delivering sustainable crop protection systems via the seed: exploiting natural constitutive and inducible defence pathways
A - Papers appearing in refereed journals
Pickett, J. A., Aradottir, G. I., Birkett, M. A., Bruce, T. J. A., Hooper, A. M., Midega, C. A. O., Jones, H. D., Matthes, M. C., Napier, J. A., Pittchar, J. O., Smart, L. E., Woodcock, C. M. and Khan, Z. R. 2014. Delivering sustainable crop protection systems via the seed: exploiting natural constitutive and inducible defence pathways. Philosophical Transactions of the Royal Society B-Biological Sciences. 369 (1639), p. 20120281. https://doi.org/10.1098/rstb.2012.0281
Permanent draft genomes of four new coccolithoviruses: EhV-18, EhV-145, EhV-156 and EhV-164
A - Papers appearing in refereed journals
Nissimov, J. I., Napier, J. A., Kimmance, S. A. and Allen, M. J. 2014. Permanent draft genomes of four new coccolithoviruses: EhV-18, EhV-145, EhV-156 and EhV-164. Marine Genomics. 15, pp. 7-8. https://doi.org/10.1016/j.margen.2014.02.004
Understanding and manipulating plant lipid composition: metabolic engineering leads the way
A - Papers appearing in refereed journals
Napier, J. A., Haslam, R. P., Beaudoin, F. and Cahoon, E. B. 2014. Understanding and manipulating plant lipid composition: metabolic engineering leads the way. Current Opinion in Plant Biology. 19, pp. 68-75. https://doi.org/10.1016/j.pbi.2014.04.001
Gene expression in plant lipid metabolism in Arabidopsis seedlings
A - Papers appearing in refereed journals
Hsiao, A-S., Haslam, R. P., Michaelson, L. V., Liao, P., Napier, J. A. and Chye, M-L. 2014. Gene expression in plant lipid metabolism in Arabidopsis seedlings. PLOS ONE. 9, p. e107372. https://doi.org/10.1371/journal.pone.0107372
Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development
A - Papers appearing in refereed journals
Hsiao, A-S., Haslam, R. P., Michaelson, L. V., Liao, P., Chen, Q-F., Sooriyaarachchi, S., Mowbray, S. L., Napier, J. A., Tanner, J. A. and Chye, M-L. 2014. Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development. Bioscience Reports. 34 (6), pp. 865-877. https://doi.org/10.1042/BSR20140139
Modifying fatty acid profiles through a new cytokinin-based plastid transformation system
A - Papers appearing in refereed journals
Dunne, A., Maple-Grodem, J., Gargano, D., Haslam, R. P., Napier, J. A., Chua, N-H., Russell, R. and Geir Moller, S. 2014. Modifying fatty acid profiles through a new cytokinin-based plastid transformation system. The Plant Journal. 80 (6), pp. 1131-1138. https://doi.org/10.1111/tpj.12684
Rice ORMDL controls sphingolipid homeostasis affecting fertility resulting from abnormal pollen development
A - Papers appearing in refereed journals
Chueasiri, C., Chunthong, K., Pitnjam, K., Chakhonkaen, S., Sangarwut, N., Sangsawang, K., Suksangpanomrung, M., Michaelson, L. V., Napier, J. A. and Muangprom, A. 2014. Rice ORMDL controls sphingolipid homeostasis affecting fertility resulting from abnormal pollen development. PLOS ONE. 9, p. e106386. https://doi.org/10.1371/journal.pone.0106386
Oleaginous crops as integrated production platforms for food, feed, fuel and renewable industrial feedstock
A - Papers appearing in refereed journals
Beaudoin, F., Sayanova, O. V., Haslam, R. P., Bancroft, I. and Napier, J. A. 2014. Oleaginous crops as integrated production platforms for food, feed, fuel and renewable industrial feedstock. OCL - Oilseeds and fats, Crops and Lipids. 21 (6), p. D606. https://doi.org/10.1051/ocl/2014042
The utilization of the acyl-CoA and the involvement PDAT and DGAT in the biosynthesis of erucic acid-rich triacylglycerols in crambe seed oil
A - Papers appearing in refereed journals
Furmanek, T., Demski, K., Banas, W., Haslam, R. P., Napier, J. A., Stymne, S. and Banas, A. 2014. The utilization of the acyl-CoA and the involvement PDAT and DGAT in the biosynthesis of erucic acid-rich triacylglycerols in crambe seed oil. Lipids. 49, pp. 327-333. https://doi.org/10.1007/s11745-014-3886-7
Successful high-level accumulation of fish oil omega-3 long-chain polyunsaturated fatty acids in a transgenic oilseed crop
A - Papers appearing in refereed journals
Ruiz-Lopez, N., Haslam, R. P., Napier, J. A. and Sayanova, O. V. 2014. Successful high-level accumulation of fish oil omega-3 long-chain polyunsaturated fatty acids in a transgenic oilseed crop. The Plant Journal. 77 (2), pp. 198-208. https://doi.org/10.1111/tpj.12378
Metabolic engineering of Phaeodactylum tricornutum for the enhanced accumulation of omega-3 long chain polyunsaturated fatty acids
A - Papers appearing in refereed journals
Hamilton, M. L., Haslam, R. P., Napier, J. A. and Sayanova, O. V. 2014. Metabolic engineering of Phaeodactylum tricornutum for the enhanced accumulation of omega-3 long chain polyunsaturated fatty acids. Metabolic Engineering. 22, pp. 3-9. https://doi.org/10.1016/j.ymben.2013.12.003
Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2669380 A1)
H2 - Patents applied for
Senger, T., Bauer, J. and Napier, J. A. 2013. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2669380 A1). EP 2669380 A1
Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent CA 2869738 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V., Ruiz-Lopez, N. and Haslam, R. P. 2013. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent CA 2869738 A1). CA 2869738 A1
Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent WO 2013/153404 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V., Ruiz-Lopez, N. and Haslam, R. P. 2013. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent WO 2013/153404 A1) . WO 2013/153404 A1
Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2376638 B1)
H1 - Patents granted
Napier, J. A., Senger, T. and Bauer, J. 2013. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2376638 B1) . EP 2376638 B1
New Elongase Gene And Production Of.delta. 9-polyunsaturated Fatty Acids (Patent CA 2442010 C)
H1 - Patents granted
Napier, J. A., Lazarus, C. M., Qi, B. and Lerchl, J. 2013. New Elongase Gene And Production Of.delta. 9-polyunsaturated Fatty Acids (Patent CA 2442010 C). CA 2442010 C
Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent CA 2476041 C)
H1 - Patents granted
Napier, J. A. and Sayanova, O. V. 2013. Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent CA 2476041 C) . CA 2476041 C
Acyltransferases And Uses Therof In Fatty Acid Production (Patent EP 2585603 A1)
H2 - Patents applied for
Senger Toralf, Marty, L., Stymne, S., Lindberg Yilmaz Jenny, Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2013. Acyltransferases And Uses Therof In Fatty Acid Production (Patent EP 2585603 A1) . EP 2585603 A1
Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2013/0097733 A1)
H2 - Patents applied for
Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2013. Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2013/0097733 A1) . US 2013/0097733 A1
Functional inferences of environmental coccolithovirus biodiversity
A - Papers appearing in refereed journals
Nissimov, J. I., Jones, M. B., Napier, J. A., Munn, C. B., Kimmance, S. A. and Allen, M. J. 2013. Functional inferences of environmental coccolithovirus biodiversity. Virologica Sinica. 28 (5), pp. 291-302. https://doi.org/10.1007/s12250-013-3362-1
Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae
A - Papers appearing in refereed journals
Vaezi, R., Napier, J. A. and Sayanova, O. V. 2013. Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae. Marine Drugs. 11 (12), pp. 5116-5129. https://doi.org/10.3390/md11125116
Pan genome of the phytoplankton Emiliania underpins its global distribution
A - Papers appearing in refereed journals
Read, B. A., Kegel, J., Klute, M. J., Kuo, A., Lefebvre, S. C., Maumus, F., Mayer, C., Miller, J., Monier, A., Salamov, A., Young, J., Aguilar, M., Claverie, J-M., Frickenhaus, S., Gonzalez, K., Herman, E. K., Lin, Y-C. and Napier, J. A. 2013. Pan genome of the phytoplankton Emiliania underpins its global distribution. Nature. 499, pp. 209-213. https://doi.org/10.1038/nature12221
Abnormal glycosphingolipid mannosylation triggers salicylic acid-mediated responses in Arabidopsis
A - Papers appearing in refereed journals
Mortimer, J. C., Yu, X., Albrecht, S., Sicilia, F., Huichalaf, M., Ampuero, D., Michaelson, L. V., Murphy, A. M., Matsunaga, T., Kurz, S., Stephens, E., Baldwin, T. C., Ishii, T., Napier, J. A., Weber, A. P. M., Handford, M. G. and Dupree, P. 2013. Abnormal glycosphingolipid mannosylation triggers salicylic acid-mediated responses in Arabidopsis. The Plant Cell. 25, pp. 1881-1894. https://doi.org/10.1105/tpc.113.111500
Plant sphingolipids: function follows form
A - Papers appearing in refereed journals
Markham, J. E., Lynch, D. V., Napier, J. A., Dunn, T. M. and Cahoon, E. B. 2013. Plant sphingolipids: function follows form. Current Opinion in Plant Biology. 16, pp. 350-357. https://doi.org/10.1016/j.pbi.2013.02.009
Reconstitution of EPA and DHA biosynthesis in Arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants
A - Papers appearing in refereed journals
Ruiz-Lopez, N., Haslam, R. P., Usher, S. L., Napier, J. A. and Sayanova, O. V. 2013. Reconstitution of EPA and DHA biosynthesis in Arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants. Metabolic Engineering. 17, pp. 30-41. https://doi.org/10.1016/j.ymben.2013.03.001
The Arabidopsis cer26 mutant, like the cer2 mutant, is specifically affected in the very long chain fatty acid elongation process
A - Papers appearing in refereed journals
Pascal, S., Bernard, A., Sorel, M., Pervent, M., Vile, D., Haslam, R. P., Napier, J. A., Lessire, R., Domergue, F. and Joubes, J. 2013. The Arabidopsis cer26 mutant, like the cer2 mutant, is specifically affected in the very long chain fatty acid elongation process. The Plant Journal. 73 (5), pp. 733-746. https://doi.org/10.1111/tpj.12060
Identification of a cytochrome b5-fusion desaturase responsible for the synthesis of triunsaturated sphingolipid long chain bases in the marine diatom Thalassiosira pseudonana
A - Papers appearing in refereed journals
Michaelson, L. V., Markham, J. E., Zaeuner, S., Matsumoto, M., Chen, M., Cahoon, E. B. and Napier, J. A. 2013. Identification of a cytochrome b5-fusion desaturase responsible for the synthesis of triunsaturated sphingolipid long chain bases in the marine diatom Thalassiosira pseudonana. Phytochemistry. 90, pp. 50-55. https://doi.org/10.1016/j.phytochem.2013.02.010
The Arabidopsis F-box/Kelch-repeat protein At2g44130 is upregulated in giant cells and promotes nematode susceptibility
A - Papers appearing in refereed journals
Curtis, R. H. C., Pankaj, Powers, S. J., Napier, J. A. and Matthes, M. C. 2013. The Arabidopsis F-box/Kelch-repeat protein At2g44130 is upregulated in giant cells and promotes nematode susceptibility. Molecular Plant-Microbe Interactions - MPMI. 26, pp. 36-43. https://doi.org/10.1094/MPMI-05-12-0135-FI
The modification of plant oil composition via metabolic engineering - better nutrition by design
A - Papers appearing in refereed journals
Haslam, R. P., Ruiz-Lopez, N., Eastmond, P. J., Moloney, M., Sayanova, O. V. and Napier, J. A. 2013. The modification of plant oil composition via metabolic engineering - better nutrition by design. Plant Biotechnology Journal. 11 (2), pp. 157-168. https://doi.org/10.1111/pbi.12012
Delta 6 Desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 8329993 B2)
H1 - Patents granted
Napier, J. A. and Sayanova, O. V. 2012. Delta 6 Desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 8329993 B2). US 8329993 B2
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8273958 B2)
H1 - Patents granted
Napier, J. A. and Sayanova, O. V. 2012. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8273958 B2) . US 8273958 B2
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8258371 B2)
H1 - Patents granted
Napier, J. A. and Sayanova, O. V. 2012. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8258371 B2) . US 8258371 B2
Semiochemical (Patent US 8221736 B2)
H1 - Patents granted
Hick, J. A., Pickett, J. A., Wadhams, L. J. and Napier, J. A. 2012. Semiochemical (Patent US 8221736 B2). US 8221736 B2
Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent EP 2454278 A1)
H2 - Patents applied for
Bauer, J., Napier, J. A. and Sayanova, O. V. 2012. Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent EP 2454278 A1). EP 2454278 A1
Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 2012/0124705 A1)
H2 - Patents applied for
Napier, J. A., Bauer , J. and Sayanova, O. V. 2012. Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 2012/0124705 A1). US 2012/0124705 A1
Novel Fatty Acid Elongation Components And Uses Thereof (Patent US 2012/0084889 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V. and Beaudoin, F. 2012. Novel Fatty Acid Elongation Components And Uses Thereof (Patent US 2012/0084889 A1) . US 2012/0084889 A1
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent EP 1937805 B1)
H1 - Patents granted
Napier, J. A. and Sayanova, O. V. 2012. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent EP 1937805 B1). EP 1937805 B1
Elongase And Uses Thereof (Patent US 8119861 B2)
H1 - Patents granted
Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2012. Elongase And Uses Thereof (Patent US 8119861 B2) . US 8119861 B2
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2012/0017332 A1)
H2 - Patents applied for
Napier, J. A. and Sayanova, O. V. 2012. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2012/0017332 A1) . US 2012/0017332 A1
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2012/0011618 A1)
H2 - Patents applied for
Napier, J. A. and Sayanova, O. V. 2012. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2012/0011618 A1) . US 2012/0011618 A1
Draft genome sequence of the Coccolithovirus Emiliania huxleyi virus 202
A - Papers appearing in refereed journals
Nissimov, J. I., Worthy, C. A., Rooks, P., Napier, J. A., Kimmance, S. A., Henn, M. R., Ogata, H. and Allen, M. J. 2012. Draft genome sequence of the Coccolithovirus Emiliania huxleyi virus 202. Journal of Virology. 86 (4), pp. 2380-2381. https://doi.org/10.1128/jvi.06863-11
Draft genome sequence of four Coccolithoviruses: Emiliania huxleyi Virus EhV-88, EhV-201, EhV-207, and EhV-208
A - Papers appearing in refereed journals
Nissimov, J. I., Worthy, C. A., Rooks, P., Napier, J. A., Kimmance, S. A., Henn, M. R., Ogata, H. and Allen, M. J. 2012. Draft genome sequence of four Coccolithoviruses: Emiliania huxleyi Virus EhV-88, EhV-201, EhV-207, and EhV-208. Journal of Virology. 86 (5), pp. 2896-2897. https://doi.org/10.1128/jvi.07046-11
Metabolic engineering of plant-derived (E)-beta-farnesene synthase genes for a novel type of aphid-resistant genetically modified crop plants
A - Papers appearing in refereed journals
Yu, X-D., Pickett, J. A., Ma, Y-Z., Bruce, T. J. A., Napier, J. A., Jones, H. D. and Xia, L-Q. 2012. Metabolic engineering of plant-derived (E)-beta-farnesene synthase genes for a novel type of aphid-resistant genetically modified crop plants. Journal of Integrative Plant Biology. 54 (5), pp. 282-299. https://doi.org/10.1111/j.1744-7909.2012.01107.x
Metabolic engineering of the omega-3 long chain polyunsaturated fatty acid biosynthetic pathway into transgenic plants
A - Papers appearing in refereed journals
Ruiz-Lopez, N., Sayanova, O. V., Napier, J. A. and Haslam, R. P. 2012. Metabolic engineering of the omega-3 long chain polyunsaturated fatty acid biosynthetic pathway into transgenic plants. Journal of Experimental Botany. 63, pp. 2397-2410. https://doi.org/10.1093/jxb/err454
Enhancing the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Arabidopsis thaliana via iterative metabolic engineering and genetic crossing
A - Papers appearing in refereed journals
Ruiz-Lopez, N., Haslam, R. P., Venegas-Caleron, M., Li, T., Bauer, J., Napier, J. A. and Sayanova, O. V. 2012. Enhancing the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Arabidopsis thaliana via iterative metabolic engineering and genetic crossing. Transgenic Research. 21, pp. 1233-1243. https://doi.org/10.1007/s11248-012-9596-0
Reconstitution of plant alkane biosynthesis in yeast demonstrates that Arabidopsis ECERIFERUM1 and ECERIFERUM3 are core components of a very-long-chain alkane synthesis complex
A - Papers appearing in refereed journals
Bernard, A., Domergue, F., Pascal, S., Jetter, R., Renne, C., Faure, J-D., Haslam, R. P., Napier, J. A., Lessire, R. and Joubes, J. 2012. Reconstitution of plant alkane biosynthesis in yeast demonstrates that Arabidopsis ECERIFERUM1 and ECERIFERUM3 are core components of a very-long-chain alkane synthesis complex. The Plant Cell. 24, pp. 3106-3118. https://doi.org/10.1105/tpc.112.099796
The role of delta6-desaturase acyl-carrier specificity in the efficient synthesis of long-chain polyunsaturated fatty acids in transgenic plants
A - Papers appearing in refereed journals
Sayanova, O. V., Ruiz-Lopez, N., Haslam, R. P. and Napier, J. A. 2012. The role of delta6-desaturase acyl-carrier specificity in the efficient synthesis of long-chain polyunsaturated fatty acids in transgenic plants. Plant Biotechnology Journal. 10 (2), pp. 195-206. https://doi.org/10.1111/j.1467-7652.2011.00653.x
Acyltransferases And Uses Therof In Fatty Acid Production (Patent CA 2804925 A1)
H2 - Patents applied for
Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2011. Acyltransferases And Uses Therof In Fatty Acid Production (Patent CA 2804925 A1) . CA 2804925 A1
Acyltransferases And Uses Therof In Fatty Acid Production (Patent WO 2011/161093 A1)
H2 - Patents applied for
Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2011. Acyltransferases And Uses Therof In Fatty Acid Production (Patent WO 2011/161093 A1). WO 2011/161093 A1
Process For The Production Of Delta5-unsaturated Fatty Acids In Transgenic Organisms (Patent EP 2388332 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V. and Zank, T. 2011. Process For The Production Of Delta5-unsaturated Fatty Acids In Transgenic Organisms (Patent EP 2388332 A1) . EP 2388332 A1
Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 2011/0277043 A1)
H2 - Patents applied for
Bauer, J., Senger, T. and Napier, J. A. 2011. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 2011/0277043 A1) . US 2011/0277043 A1
Process For Producing A Polyunsatured Fatty Acid Comprising Arachidonic Acid (Patent EP 2380984 A2)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2011. Process For Producing A Polyunsatured Fatty Acid Comprising Arachidonic Acid (Patent EP 2380984 A2) . EP 2380984 A2
Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2376638 A2)
H2 - Patents applied for
Napier, J. A., Senger, T. and Bauer, J. 2011. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2376638 A2). EP 2376638 A2
Process For The Production Of Delta5-unsaturated Fatty Acids In Transgenic Organisms (Patent EP 2366781 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V. and Zank, T. 2011. Process For The Production Of Delta5-unsaturated Fatty Acids In Transgenic Organisms (Patent EP 2366781 A1) . EP 2366781 A1
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8017839 B2)
H1 - Patents granted
Napier, J. A. and Sayanova, O. V. 2011. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8017839 B2) . US 8017839 B2
Method For The Production Of Γ-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent US 8013216 B2 )
H1 - Patents granted
Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2011. Method For The Production Of Γ-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent US 8013216 B2 ). US 8013216 B2
Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1726652 B1)
H1 - Patents granted
Napier, J. A. and Sayanova, O. V. 2011. Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1726652 B1). EP 1726652 B1
Recombinant Cells And Plants For Synthesis Of Very Long Chains Fatty Acid (vlcfa) (Patent US 2011/0189697 A1)
H2 - Patents applied for
Faure, J-D., Bach, L., Miquel, M. and Napier, J. A. 2011. Recombinant Cells And Plants For Synthesis Of Very Long Chains Fatty Acid (vlcfa) (Patent US 2011/0189697 A1) . US 2011/0189697 A1
Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 2011/0138490 A1)
H2 - Patents applied for
Bauer, J., Napier, J. A. and Sayanova, O. V. 2011. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 2011/0138490 A1) . US 2011/0138490 A1
Nucleic Acid (Patent EP 1984502 B1)
H1 - Patents granted
Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2011. Nucleic Acid (Patent EP 1984502 B1). EP 1984502 B1
Recombinant Cells And Plants For Synthesis Of Very Long Chains Fatty Acid (vlcfa) (Patent EP 2310512 A1)
H2 - Patents applied for
Faure, J-D., Bach, L., Miquel, M. and Napier, J. A. 2011. Recombinant Cells And Plants For Synthesis Of Very Long Chains Fatty Acid (vlcfa) (Patent EP 2310512 A1) . EP 2310512 A1
Method For The Production Of Gamma-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent EP 1945775 B1)
H1 - Patents granted
Napier, J. A., Sayanova, O. V. and Vengas, C. M. 2011. Method For The Production Of Gamma-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent EP 1945775 B1) . EP 1945775 B1
Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2281051 A1)
H2 - Patents applied for
Bauer, J., Napier, J. A. and Sayanova, O. V. 2011. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2281051 A1) . EP 2281051 A1
Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent CA 2768082 A1)
H2 - Patents applied for
Bauer, J., Napier, J. A. and Sayanova, O. V. 2011. Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent CA 2768082 A1) . CA 2768082 A1
Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent WO 2011/006948 A1)
H2 - Patents applied for
Bauer, J., Napier, J. A. and Sayanova, O. V. 2011. Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent WO 2011/006948 A1). WO 2011/006948 A1
Transgenic wheat emitting aphid alarm pheromone, (E)-beta-farnesene
C1 - Edited contributions to conferences/learned societies
Bruce, T. J. A., Smart, L. E., Martin, J. L., Doherty, A., Jones, H. D., Napier, J. A. and Pickett, J. A. 2011. Transgenic wheat emitting aphid alarm pheromone, (E)-beta-farnesene. GM Crops: from Basic Research to Application. Aspects of Applied Biology 110 . Association of Applied Biologists (AAB) Wellesbourne Warwick . pp. 24
Transgenic wheat emitting aphid alarm pheromone, (E)-beta-farnesene
C1 - Edited contributions to conferences/learned societies
Bruce, T. J. A., Smart, L. E., Aradottir, G. I., Martin, J. L., Doherty, A., Jones, H. D., Napier, J. A. and Pickett, J. A. 2011. Transgenic wheat emitting aphid alarm pheromone, (E)-beta-farnesene. GM Crops: from Basic Research to Application. Aspects of Applied Biology 110 . Association of Applied Biologists (AAB) Wellesbourne Warwick . pp. 112
Transgenic wheat emitting aphid alarm pheromone, (E)-beta-farnesene
C2 - Non-edited contributions to conferences
Bruce, T. J. A., Smart, L. E., Aradottir, G. I., Martin, J. L., Doherty, A., Jones, H. D., Napier, J. A. and Pickett, J. A. 2011. Transgenic wheat emitting aphid alarm pheromone, (E)-beta-farnesene. Abstracts Ento' 11 Symposium on Chemical Ecology: Reception, Detection and Deception, Chatham, 7-9 September 2011 . pp. 54
Draft genome sequence of the coccolithovirus EhV-84
A - Papers appearing in refereed journals
Nissimov, J. I., Worthy, C. A., Rooks, P., Napier, J. A., Kimmance, S. A., Henn, M. R., Ogata, H. and Allen, M. J. 2011. Draft genome sequence of the coccolithovirus EhV-84. Standards in Genomic Sciences. 5, pp. 1-11. https://doi.org/10.4056/sigs.1884581
Transgenic oilseed crops as an alternative to fish oils
A - Papers appearing in refereed journals
Sayanova, O. V. and Napier, J. A. 2011. Transgenic oilseed crops as an alternative to fish oils. Prostaglandins, Leukotrienes and Essential Fatty Acids. 85, pp. 253-260. https://doi.org/10.1016/j.plefa.2011.04.013
Draft genome sequence of the coccolithovirus Emiliania huxleyi virus 203
A - Papers appearing in refereed journals
Nissimov, J. I., Worthy, C. A., Rooks, P., Napier, J. A., Kimmance, S. A., Henn, M. R., Ogata, H. and Allen, M. J. 2011. Draft genome sequence of the coccolithovirus Emiliania huxleyi virus 203. Journal of Virology. 85 (24), pp. 13468-13469. https://doi.org/10.1128/JVI.06440-11
Targeted enhancement of glutamate-to-gamma-aminobutyrate conversion in Arabidopsis seeds affects carbon-nitrogen balance and storage reserves in a development-dependent manner
A - Papers appearing in refereed journals
Fait, A., Nunes Nesi, A., Angelovici, R., Lehmann, M., Anh Pham, P., Song, L., Haslam, R. P., Napier, J. A., Galili, G. and Fernie, A. R. 2011. Targeted enhancement of glutamate-to-gamma-aminobutyrate conversion in Arabidopsis seeds affects carbon-nitrogen balance and storage reserves in a development-dependent manner. Plant Physiology. 157, pp. 1026-1042. https://doi.org/10.1104/pp.111.179986
LC-MS/MS methods for absolute quantification and identification of proteins associated with chimeric plant oil bodies
A - Papers appearing in refereed journals
Capuano, F., Bond, N. J., Gatto, L., Beaudoin, F., Napier, J. A., Benvenuto, E., Lilley, K. S. and Baschieri, S. 2011. LC-MS/MS methods for absolute quantification and identification of proteins associated with chimeric plant oil bodies. Analytical Chemistry. 83, pp. 9267-9272. https://doi.org/10.1021/ac201733m
Very-long-chain fatty acids are required for cell plate formation during cytokinesis in Arabidopsis thaliana
A - Papers appearing in refereed journals
Bach, L., Gissot, L., Marion, J., Tellier, F., Moreau, P., Satiat-Jeunemaitre, B., Palauqui, J-C., Napier, J. A. and Faure, J-D. 2011. Very-long-chain fatty acids are required for cell plate formation during cytokinesis in Arabidopsis thaliana. Journal Of Cell Science. 124, pp. 3223-234. https://doi.org/10.1242/jcs.074575
Coccolithophores: functional biodiversity, enzymes and bioprospecting
A - Papers appearing in refereed journals
Reid, E. L., Worthy, C. A., Probert, I., Ali, S. T., Love, J., Napier, J. A., Littlechild, J. A., Somerfield, P. J. and Allen, M. J. 2011. Coccolithophores: functional biodiversity, enzymes and bioprospecting. Marine Drugs. 9 (4), pp. 586-602. https://doi.org/10.3390/md9040586
Emerging roles in plant defense for cis- jasmone-induced cytochrome P450 CYP81D11
A - Papers appearing in refereed journals
Matthes, M. C., Bruce, T. J. A., Chamberlain, K., Pickett, J. A. and Napier, J. A. 2011. Emerging roles in plant defense for cis- jasmone-induced cytochrome P450 CYP81D11. Plant Signaling and Behavior. 6, pp. 563-565. https://doi.org/10.4161/psb.6.4.14915
New frontiers in oilseed biotechnology: meeting the global demand for vegetable oils for food, feed, biofuel and industrial applications
A - Papers appearing in refereed journals
Lu, C., Napier, J. A., Clemente, T. E. and Cahoon, E. B. 2011. New frontiers in oilseed biotechnology: meeting the global demand for vegetable oils for food, feed, biofuel and industrial applications. Current Opinion in Biotechnology. 22, pp. 252-259. https://doi.org/10.1016/j.copbio.2010.11.006
Overexpression of Arabidopsis ECERIFERUM1 promotes wax very-long-chain alkane biosynthesis and influences plant response to biotic and abiotic stresses
A - Papers appearing in refereed journals
Bourdenx, B., Bernard, A., Domergue, F., Pascal, S., Leger, A., Roby, D., Pervent, M., Vile, D., Haslam, R. P., Napier, J. A., Lessire, R. and Joubes, J. 2011. Overexpression of Arabidopsis ECERIFERUM1 promotes wax very-long-chain alkane biosynthesis and influences plant response to biotic and abiotic stresses. Plant Physiology. 156, pp. 29-45. https://doi.org/10.1104/pp.111.172320
Metabolic engineering of Saccharomyces cerevisiae for production of eicosapentaenoic acid, using a novel delta5-desaturase from Paramecium tetraurelia
A - Papers appearing in refereed journals
Tavares, S., Grotkjaer, T., Obsen, T., Haslam, R. P., Napier, J. A. and Gunnarsson, N. 2011. Metabolic engineering of Saccharomyces cerevisiae for production of eicosapentaenoic acid, using a novel delta5-desaturase from Paramecium tetraurelia. Applied and Environmental Microbiology. 77, pp. 1854-1861. https://doi.org/10.1128/AEM.01935-10
Identification and functional characterisation of genes encoding the omega-3 polyunsaturated fatty acid biosynthetic pathway from the coccolithophore Emiliania huxleyi
A - Papers appearing in refereed journals
Sayanova, O. V., Haslam, R. P., Venegas Caleron, M., Ruiz-Lopez, N., Worthy, C., Rooks, P., Allen, M. J. and Napier, J. A. 2011. Identification and functional characterisation of genes encoding the omega-3 polyunsaturated fatty acid biosynthetic pathway from the coccolithophore Emiliania huxleyi. Phytochemistry. 72, pp. 594-600. https://doi.org/10.1016/j.phytochem.2011.01.022
Foresight project on global food and farming futures: application of genetics and genomics to aquaculture development: current and future directions
A - Papers appearing in refereed journals
Mcandrew, B. and Napier, J. A. 2011. Foresight project on global food and farming futures: application of genetics and genomics to aquaculture development: current and future directions. The Journal of Agricultural Science. 149, pp. 143-151. https://doi.org/10.1017/S0021859610001152
ELVOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice
A - Papers appearing in refereed journals
Zadravec, D., Tvrdik, P., Guillou, H., Haslam, R. P., Kobayashi, T., Napier, J. A., Capecchi, M. R. and Jacobsson, A. 2011. ELVOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice. Journal Of Lipid Research. 52 (2), pp. 245-255. https://doi.org/10.1194/jlr.M011346
New Elongase Gene And Production Of Delta-9-polyunsaturated Fatty Acids (Patent EP 1373519 B1)
H1 - Patents granted
Napier, J. A., Lazarus, C. M., Qi, B. and Lerchl, J. 2010. New Elongase Gene And Production Of Delta-9-polyunsaturated Fatty Acids (Patent EP 1373519 B1). EP 1373519 B1
Semiochemical (Patent US 7820153 B2)
H1 - Patents granted
Hick, A. J., Pickett, J. A., Wadhams, L. J. and Napier, J. A. 2010. Semiochemical (Patent US 7820153 B2) . US 7820153 B2
Semiochemical (Patent US 2010/0226877 A1)
H2 - Patents applied for
Hick, A. J., Pickett, J. A., Wadhams, L. J. and Napier, J. A. 2010. Semiochemical (Patent US 2010/0226877 A1) . US 2010/0226877 A1
Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent WO 2010/066703 A2)
H2 - Patents applied for
Napier, J. A. 2010. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent WO 2010/066703 A2) . WO 2010/066703 A2
Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent CA 2744930 A1)
H2 - Patents applied for
Napier, J. A., Senger Toralf and Bauer Joerg 2010. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent CA 2744930 A1) . CA 2744930 A1
Process For The Production Of Δ5-unsaturated Fatty Acids In Transgenic Organisms (Patent US 7723574 B2)
H1 - Patents granted
Zank, T., Napier, J. A. and Sayanova, O. V. 2010. Process For The Production Of Δ5-unsaturated Fatty Acids In Transgenic Organisms (Patent US 7723574 B2). US 7723574 B2
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2010/0043103 A1)
H2 - Patents applied for
Napier, J. A. and Sayanova, O. V. 2010. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2010/0043103 A1). US 2010/0043103 A1
Viral trans- dominant manipulation of algal sphingolipids
A - Papers appearing in refereed journals
Michaelson, L. V., Dunn, T. M. and Napier, J. A. 2010. Viral trans- dominant manipulation of algal sphingolipids. Trends in Plant Science. 15, pp. 651-655. https://doi.org/10.1016/j.tplants.2010.09.004
The production of Omega-3 Very Long-Chain Polyunsaturated Fatty Acids in transgenic plants: a sustainable source of omega-3 fish oils
C2 - Non-edited contributions to conferences
Ruiz-Lopez, N., Haslam, R. P., Sayanova, O. V. and Napier, J. A. 2010. The production of Omega-3 Very Long-Chain Polyunsaturated Fatty Acids in transgenic plants: a sustainable source of omega-3 fish oils. Abstracts from the 51st International Conference on the Bioscience of Lipids. https://doi.org/10.1016/j.chemphyslip.2010.05.055
Very long chain fatty acids are required for cell polarity and organogenesis during plant development
C2 - Non-edited contributions to conferences
Molino, D., Markham, J. E., Bellec, Y., Gissot, L., Palauqui, J-C., Moreau, P., Napier, J. A. and Faure, J. D. 2010. Very long chain fatty acids are required for cell polarity and organogenesis during plant development. https://doi.org/10.1016/j.chemphyslip.2010.05.054
The transcriptome of cis -jasmone-induced resistance in Arabidopsis thaliana and its role in indirect defence
A - Papers appearing in refereed journals
Matthes, M. C., Bruce, T. J. A., Ton, J., Verrier, P. J., Pickett, J. A. and Napier, J. A. 2010. The transcriptome of cis -jasmone-induced resistance in Arabidopsis thaliana and its role in indirect defence. Planta. 232, pp. 1163-1180. https://doi.org/10.1007/s00425-010-1244-4
The sunflower plastidial omega3-fatty acid desaturase (Ha FAD7) contains the signalling determinants required for targeting to, and retention in, the endoplasmic reticulum membrane in yeast but requires co-expressed ferredoxin for activity
A - Papers appearing in refereed journals
Venegas-Caleron, M., Beaudoin, F., Garces, R., Napier, J. A. and Martinez-Force, E. 2010. The sunflower plastidial omega3-fatty acid desaturase (Ha FAD7) contains the signalling determinants required for targeting to, and retention in, the endoplasmic reticulum membrane in yeast but requires co-expressed ferredoxin for activity. Phytochemistry. 71, pp. 1050-1058. https://doi.org/10.1016/j.phytochem.2010.04.017
Very-long-chain fatty acids are involved in polar auxin transport and developmental patterning in Arabidopsis
A - Papers appearing in refereed journals
Roudier, F., Gissot, L., Beaudoin, F., Haslam, R. P., Michaelson, L. V., Marion, J., Molino, D., Lima, A., Bach, L., Morin, H., Tellier, F., Palauqui, J-C., Bellec, Y., Renne, C., Miquel, M., Dacosta, M., Vignard, J., Rochat, C., Markham, J. E., Moreau, P., Napier, J. A. and Faure, J-D. 2010. Very-long-chain fatty acids are involved in polar auxin transport and developmental patterning in Arabidopsis. The Plant Cell. 22, pp. 364-375. https://doi.org/10.1105/tpc.109.071209
As simple as ACB - new insights into the role of acyl-CoA-binding proteins in Arabidopsis
A - Papers appearing in refereed journals
Napier, J. A. and Haslam, R. P. 2010. As simple as ACB - new insights into the role of acyl-CoA-binding proteins in Arabidopsis. New Phytologist. 186 (4), pp. 781-783. https://doi.org/10.1111/j.1469-8137.2010.03287.x
Tailoring plant lipid composition: designer oilseeds come of age
A - Papers appearing in refereed journals
Napier, J. A. and Graham, I. A. 2010. Tailoring plant lipid composition: designer oilseeds come of age. Current Opinion in Plant Biology. 13, pp. 330-337. https://doi.org/10.1016/j.pbi.2010.01.008
Sphingolipid signaling in plants
B - Book chapters etc edited externally
Michaelson, L. V. and Napier, J. A. 2010. Sphingolipid signaling in plants. in: Munnik, T. (ed.) Lipid signaling in plants (Plant Cell Monographs, 16) Springer, Berlin. pp. 307-321
An alternative to fish oils: metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids
A - Papers appearing in refereed journals
Venegas-Caleron, M., Sayanova, O. V. and Napier, J. A. 2010. An alternative to fish oils: metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids. Progress in Lipid Research. 49, pp. 108-119. https://doi.org/10.1016/j.plipres.2009.10.001
Recombinant Cells And Plants For Synthesis Of Very Long Chains Fatty Acid (vlcfa) (Patent WO 2009/156469 A1)
H2 - Patents applied for
Faure, J-D., Bach, L., Miquel, M. and Napier, J. A. 2009. Recombinant Cells And Plants For Synthesis Of Very Long Chains Fatty Acid (vlcfa) (Patent WO 2009/156469 A1) . WO 2009/156469 A1
Recombinant Cells And Plants For Synthesis Of Very Long Chains Fatty Acid (vlcfa) (Patent CA 2727894 A1)
H2 - Patents applied for
Faure, J-D., Bach, L., Miquel, M. and Napier, J. A. 2009. Recombinant Cells And Plants For Synthesis Of Very Long Chains Fatty Acid (vlcfa) (Patent CA 2727894 A1). CA 2727894 A1
Cis-jasmone As Semiochemical (Patent CA 2388964 C)
H1 - Patents granted
Wadhams, L. J., Hick, A. J., Pickett, J. A. and Napier, J. A. 2009. Cis-jasmone As Semiochemical (Patent CA 2388964 C) . CA 2388964 C
Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent WO 2009/133145 A1)
H2 - Patents applied for
Bauer, J., Napier, J. A. and Sayanova, O. V. 2009. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent WO 2009/133145 A1) . WO 2009/133145 A1
Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent CA 2723072 A1)
H2 - Patents applied for
Bauer, J., Napier, J. A. and Sayanova, O. V. 2009. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent CA 2723072 A1). CA 2723072 A1
Elongase Gene And Production Of Delta9-polyunsaturated Fatty Acids (Patent US 7601889 B2)
H1 - Patents granted
Napier, J. A., Larzarus C. M., Qi, B. and Lerchl, J. 2009. Elongase Gene And Production Of Delta9-polyunsaturated Fatty Acids (Patent US 7601889 B2) . US 7601889 B2
Delta 6 Desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 2009/0222955 A1)
H2 - Patents applied for
Napier, J. A. and Sayanova, O. V. 2009. Delta 6 Desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 2009/0222955 A1) . US 2009/0222955 A1
Delta6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 7554008 B2)
H1 - Patents granted
Napier, J. A. and Sayanova, O. V. 2009. Delta6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 7554008 B2) . US 7554008 B2
Nucleic Acid (Patent US 2009/0019559 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V. and Caleron, M. V. 2009. Nucleic Acid (Patent US 2009/0019559 A1). US 2009/0019559 A1
Misexpression of FATTY ACID ELONGATION1 in the Arabidopsis Epidermis Induces Cell Death and Suggests a Critical Role for Phospholipase A2 in This Process
A - Papers appearing in refereed journals
Reina-Pinto, J. J., Voisin, D., Kurdyukov, S., Faust, A., Haslam, R. P., Michaelson, L. V., Efremova, N., Franke, B., Schreiber, L., Napier, J. A. and Yephremov, A. 2009. Misexpression of FATTY ACID ELONGATION1 in the Arabidopsis Epidermis Induces Cell Death and Suggests a Critical Role for Phospholipase A2 in This Process. The Plant Cell. 21 (4), pp. 1252-1272. https://doi.org/10.1105/tpc.109.065565
Plant defences induced by foliar application of jasmonates reduces infection of Meloidogyne incognita and Globodera pallida in Solanum lycopersicum
C2 - Non-edited contributions to conferences
Curtis, R. H. C., Matthews, M., Pankaj, Birkett, M. A., Pye, B., Napier, J. A., Pickett, J. A. and Kerry, B. R. 2009. Plant defences induced by foliar application of jasmonates reduces infection of Meloidogyne incognita and Globodera pallida in Solanum lycopersicum. Abstracts AAB Conference on Advances in Nematology, London, 15 December 2009 .
The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of 'heart-healthy' omega-3 fatty acids
A - Papers appearing in refereed journals
Ruiz-Lopez, N., Haslam, R. P., Venegas-Caleron, M., Larson, T. R., Graham, I. A., Napier, J. A. and Sayanova, O. V. 2009. The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of 'heart-healthy' omega-3 fatty acids. Plant Biotechnology Journal. 7 (7), pp. 704-716. https://doi.org/10.1111/j.1467-7652.2009.00436.x
Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase
A - Papers appearing in refereed journals
Beaudoin, F., Wu, X., Li, F., Haslam, R. P., Markham, J. E., Zheng, H., Napier, J. A. and Kunst, L. 2009. Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase. Plant Physiology. 150, pp. 1174-1191. https://doi.org/10.1104/pp.109.137497
Functional characterization of a higher plant sphingolipid delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis
A - Papers appearing in refereed journals
Michaelson, L. V., Zauner, S., Markham, J. E., Haslam, R. P., Desikan, R., Mugford, S., Albrecht, S., Warnecke, D., Sperling, P., Heinz, E. and Napier, J. A. 2009. Functional characterization of a higher plant sphingolipid delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis. Plant Physiology. 149, pp. 487-498. https://doi.org/10.1104/pp.108.129411
Nucleic Acid (Patent EP 1984502 A2)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2008. Nucleic Acid (Patent EP 1984502 A2) . EP 1984502 A2
Method For The Production Of Gamma-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent US 2008/0229454 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V. and Caleron, M. V. 2008. Method For The Production Of Gamma-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent US 2008/0229454 A1) . US 2008/0229454 A1
Method For The Production Of Gamma-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent EP 1945775 A2)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2008. Method For The Production Of Gamma-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent EP 1945775 A2) . EP 1945775 A2
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent EP 1937805 A2)
H2 - Patents applied for
Napier, J. A. and Sayanova, O. V. 2008. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent EP 1937805 A2) . EP 1937805 A2
Peroxisomal ATP import is essential for seedling development in Arabidopsis thaliana
A - Papers appearing in refereed journals
Linka, N., Theodoulou, F. L., Haslam, R. P., Linka, M., Napier, J. A., Neuhaus, H. E. and Weber, A. P. M. 2008. Peroxisomal ATP import is essential for seedling development in Arabidopsis thaliana. The Plant Cell. 20, pp. 3241-3257. https://doi.org/10.1105/tpc.108.062042
Natural variation in responsiveness of Arabidopsis thaliana to methyl jasmonate is developmentally regulated
A - Papers appearing in refereed journals
Matthes, M. C., Pickett, J. A. and Napier, J. A. 2008. Natural variation in responsiveness of Arabidopsis thaliana to methyl jasmonate is developmentally regulated. Planta. 228, pp. 1021-1028. https://doi.org/10.1007/s00425-008-0804-3
The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development
A - Papers appearing in refereed journals
Bach, L., Michaelson, L. V., Haslam, R. P., Bellec, Y., Gissot, L., Marion, J., Da Costa, M., Boutin, J-P., Miquel, M., Tellier, F., Domergue, F., Markham, J. E., Beaudoin, F., Napier, J. A. and Faure, J-D. 2008. The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development. Proceedings of the National Academy of Sciences. 105, pp. 14727-14731. https://doi.org/10.1073/pnas.0805089105
cis- Jasmone induces Arabidopsis genes that affect the chemical ecology of multitrophic interactions with aphids and their parasitoids
A - Papers appearing in refereed journals
Bruce, T. J. A., Matthes, M. C., Chamberlain, K., Woodcock, C. M., Mohib, A., Webster, B., Smart, L. E., Birkett, M. A., Pickett, J. A. and Napier, J. A. 2008. cis- Jasmone induces Arabidopsis genes that affect the chemical ecology of multitrophic interactions with aphids and their parasitoids. Proceedings of the National Academy of Sciences. 105, pp. 4553-4558. https://doi.org/10.1073/pnas.0710305105
Nucleic Acid (Patent CA 2641425 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2007. Nucleic Acid (Patent CA 2641425 A1). CA 2641425 A1
Nucleic Acid (Patent WO 2007/093776 A2)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2007. Nucleic Acid (Patent WO 2007/093776 A2) . WO 2007/093776 A2
Nucleic Acids Which Encode Delta9-elongases, Delta8-desaturases And Delta5-desaturases, Uses And Processes Thereof (Patent CA 3006116 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2007. Nucleic Acids Which Encode Delta9-elongases, Delta8-desaturases And Delta5-desaturases, Uses And Processes Thereof (Patent CA 3006116 A1) . CA 3006116 A1
Process For The Production Of Delta5-unsaturated Fatty Acids In Transgenic Organisms (Patent US 2007/0136892 A1)
H2 - Patents applied for
Zank, T., Napier, J. A. and Sayanova, O. V. 2007. Process For The Production Of Delta5-unsaturated Fatty Acids In Transgenic Organisms (Patent US 2007/0136892 A1) . US 2007/0136892 A1
Process For The Production Of Delta 5-unsaturated Fatty Acids In Transgenic Organisms (Patent EP 1790731 A2)
H2 - Patents applied for
Zank, T., Sayanova, O. V. and Napier, J. A. 2007. Process For The Production Of Delta 5-unsaturated Fatty Acids In Transgenic Organisms (Patent EP 1790731 A2) . EP 1790731 A2
Process For The Production Of .delta.5-unsaturated Fatty Acids In Transgenic Organisms (Patent CA 2567132 A1)
H2 - Patents applied for
Zank, T., Sayanova, O. V. and Napier, J. A. 2007. Process For The Production Of .delta.5-unsaturated Fatty Acids In Transgenic Organisms (Patent CA 2567132 A1). CA 2567132 A1
Method For The Production Of .gamma.-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent CA 2625505 A1)
H2 - Patents applied for
Venegas, C. M., Sayanova, O. V. and Napier, J. A. 2007. Method For The Production Of .gamma.-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent CA 2625505 A1). CA 2625505 A1
Method For The Production Of ?-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent WO 2007/051577 A2)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2007. Method For The Production Of ?-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent WO 2007/051577 A2) . WO 2007/051577 A2
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent WO 2007/042510 A2)
H2 - Patents applied for
Napier, J. A. and Sayanova, O. V. 2007. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent WO 2007/042510 A2). WO 2007/042510 A2
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent CA 2621214 A1)
H2 - Patents applied for
Napier, J. A. and Sayanova, O. V. 2007. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent CA 2621214 A1). CA 2621214 A1
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent CA 3021294 A1)
H2 - Patents applied for
Napier, J. A. and Sayanova, O. V. 2007. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent CA 3021294 A1). CA 3021294 A1
Process For The Production Of Arachidonic And/or Eicosapentaenoic Acid (Patent GB 2431158 A)
H2 - Patents applied for
Sayanova, O. V. and Napier, J. A. 2007. Process For The Production Of Arachidonic And/or Eicosapentaenoic Acid (Patent GB 2431158 A) . GB 2431158 A
Developments in aspects of ecological phytochemistry: the role of cis -jasmone in inducible defence systems in plants
A - Papers appearing in refereed journals
Pickett, J. A., Birkett, M. A., Bruce, T. J. A., Chamberlain, K., Gordon-Weeks, R., Matthes, M. C., Napier, J. A., Smart, L. E. and Woodcock, C. M. 2007. Developments in aspects of ecological phytochemistry: the role of cis -jasmone in inducible defence systems in plants. Phytochemistry. 68 (22-24), pp. 2937-2945. https://doi.org/10.1016/j.phytochem.2007.09.025
Stressful 'memories' of plants: evidence and possible mechanisms
A - Papers appearing in refereed journals
Bruce, T. J. A., Matthes, M. C., Napier, J. A. and Pickett, J. A. 2007. Stressful 'memories' of plants: evidence and possible mechanisms. Plant Science. 173, pp. 603-608. https://doi.org/10.1016/j.plantsci.2007.09.002
Properties and exploitation of oleosins
A - Papers appearing in refereed journals
Capuano, F., Beaudoin, F., Napier, J. A. and Shewry, P. R. 2007. Properties and exploitation of oleosins. Biotechnology Advances. 25, pp. 203-206. https://doi.org/10.1016/j.biotechadv.2006.11.006
Using epitope tagging to explore the trafficking, location and functional properties of wheat gluten proteins
C1 - Edited contributions to conferences/learned societies
Shewry, P. R., Tosi, P., Jones, H. D., Sparks, C. A., Gritsch, C., Funatsuki, W., Niwa, K., Huttly, A. K., Napier, J. A., D'ovidio, R. and Freeman, J. 2007. Using epitope tagging to explore the trafficking, location and functional properties of wheat gluten proteins. Lookhart, G. L. and Ng, P. W. K. (ed.) Gluten proteins 2006 . American Association of Cereal Chemists (AACC), St Paul, MN. pp. 112-116
Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: identification of an acyl-coenzyme A C20 delta5-desaturase responsible for the synthesis of sciadonic acid
A - Papers appearing in refereed journals
Sayanova, O. V., Haslam, R. P., Venegas Caleron, M. and Napier, J. A. 2007. Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: identification of an acyl-coenzyme A C20 delta5-desaturase responsible for the synthesis of sciadonic acid. Plant Physiology. 144, pp. 455-467. https://doi.org/10.1104/pp.107.098202
Characterization of lipid rafts from Medicago truncatula root plasma membranes: a proteomic study reveals the presence of a raft-associated redox system
A - Papers appearing in refereed journals
Lefebvre, B., Furt, F., Hartmann, M-A., Michaelson, L. V., Carde, J-P., Sargueil-Boiron, F., Rossignol, M., Napier, J. A., Cullimore, J., Bessoule, J-J. and Mongrand, S. 2007. Characterization of lipid rafts from Medicago truncatula root plasma membranes: a proteomic study reveals the presence of a raft-associated redox system. Plant Physiology. 144, pp. 402-418. https://doi.org/10.1104/pp.106.094102
Rational metabolic engineering of transgenic plants for biosynthesis of omega-3 polyunsaturates
A - Papers appearing in refereed journals
Graham, I. A., Larson, T. and Napier, J. A. 2007. Rational metabolic engineering of transgenic plants for biosynthesis of omega-3 polyunsaturates. Current Opinion in Biotechnology. 18, pp. 142-147. https://doi.org/10.1016/j.copbio.2007.01.014
Cloning and molecular characterisation of a delta8- sphingolipid-desaturase from Nicotiana tabacum closely related to delta6-acyl-desaturases
A - Papers appearing in refereed journals
Garcia-Maroto, F., Garrido-Cardenas, J. A., Michaelson, L. V., Napier, J. A. and Alonso, D. L. 2007. Cloning and molecular characterisation of a delta8- sphingolipid-desaturase from Nicotiana tabacum closely related to delta6-acyl-desaturases. Plant Molecular Biology. 64, pp. 241-250. https://doi.org/10.1007/s11103-007-9148-9
The production of unusual fatty acids in transgenic plants
A - Papers appearing in refereed journals
Napier, J. A. 2007. The production of unusual fatty acids in transgenic plants. Annual Review of Plant Biology. 58, pp. 295-319. https://doi.org/10.1146/annurev.arplant.58.032806.103811
Are GM and conventionally bred cereals really different?
A - Papers appearing in refereed journals
Shewry, P. R., Baudo, M., Lovegrove, A., Powers, S. J., Napier, J. A., Ward, J. L., Baker, J. M. and Beale, M. H. 2007. Are GM and conventionally bred cereals really different? Trends in Food Science and Technology. 18, pp. 201-209. https://doi.org/10.1016/j.tifs.2006.12.010
Co-transcribed genes for long chain polyunsaturated fatty acid biosynthesis in the protozoon Perkinsus marinus include a plant-like FAE1 3-ketoacyl coenzyme A synthase
A - Papers appearing in refereed journals
Venegas-Caleron, M., Beaudoin, F., Sayanova, O. V. and Napier, J. A. 2007. Co-transcribed genes for long chain polyunsaturated fatty acid biosynthesis in the protozoon Perkinsus marinus include a plant-like FAE1 3-ketoacyl coenzyme A synthase. Journal of Biological Chemistry. 282, pp. 2996-3003. https://doi.org/10.1074/jbc.M607051200
cis -Jasmone as allelopathic agent in inducing plant defence
A - Papers appearing in refereed journals
Pickett, J. A., Birkett, M. A., Blassioli Moraes, M. C., Bruce, T. J. A., Chamberlain, K., Gordon-Weeks, R., Matthes, M. C., Napier, J. A., Smart, L. E., Wadhams, L. J. and Woodcock, C. M. 2007. cis -Jasmone as allelopathic agent in inducing plant defence. Allelopathy Journal. 19 (1), pp. 109-118.
Transgenic plants as a source of fish oils: healthy, sustainable and GM
A - Papers appearing in refereed journals
Napier, J. A. 2007. Transgenic plants as a source of fish oils: healthy, sustainable and GM. Journal of the Science of Food and Agriculture. 87 (1), pp. 8-12. https://doi.org/10.1002/jsfa.2665
Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1726652 A2)
H2 - Patents applied for
Napier, J. A. and Sayanova, O. V. 2006. Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1726652 A2) . EP 1726652 A2
Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent US 2006/0246556 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V., Lazarus, C., Qi, B., Heinz, E., Zank, T. and Zahringer, U. 2006. Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent US 2006/0246556 A1) . US 2006/0246556 A1
Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1481063 B1)
H1 - Patents granted
Napier, J. A. and Sayanova, O. V. 2006. Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1481063 B1) . EP 1481063 B1
The production of n-3 long-chain polyunsaturated fatty acids in transgenic plants
A - Papers appearing in refereed journals
Napier, J. A. 2006. The production of n-3 long-chain polyunsaturated fatty acids in transgenic plants. European Journal Of Lipid Science And Technology. 108 (11), pp. 965-972. https://doi.org/10.1002/ejlt.200600180
A bifunctional delta12, delta15-desaturase from Acanthamoeba castellanii directs the synthesis of highly unusual n -1 series unsaturated fatty acids
A - Papers appearing in refereed journals
Sayanova, O. V., Haslam, R. P., Guschina, I., Lloyd, D., Christie, W. W., Harwood, J. L. and Napier, J. A. 2006. A bifunctional delta12, delta15-desaturase from Acanthamoeba castellanii directs the synthesis of highly unusual n -1 series unsaturated fatty acids. Journal of Biological Chemistry. 281, pp. 36533-36541. https://doi.org/10.1074/jbc.M605158200
Identification of Primula "front-end" desaturases with distinct n -6 or n -3 substrate preferences
A - Papers appearing in refereed journals
Sayanova, O. V., Haslam, R. P., Venegas-Caleron, M. and Napier, J. A. 2006. Identification of Primula "front-end" desaturases with distinct n -6 or n -3 substrate preferences. Planta. 224, pp. 1269-1277. https://doi.org/10.1007/s00425-006-0306-0
Alterations in sphingolipid synthesis in the model plant Arabidopsis thaliana is associated with cell polarity and developmental defects
C2 - Non-edited contributions to conferences
Roudier, F., Gissot, L., Vignard, J., Rochas, C., Moreau, P., Napier, J. A., Morin, H., Bellec, Y., Palauqui, J-C. and Faure, J-D. 2006. Alterations in sphingolipid synthesis in the model plant Arabidopsis thaliana is associated with cell polarity and developmental defects.
Fish oils from plants
G - Articles in popular magazines and other technical publications
Napier, J. A. 2006. Fish oils from plants. RRA Newsletter. No. 22, p. 2.
A metabolomic study of substantial equivalence of field-grown genetically modified wheat
A - Papers appearing in refereed journals
Baker, J. M., Hawkins, N. D., Ward, J. L., Lovegrove, A., Napier, J. A., Shewry, P. R. and Beale, M. H. 2006. A metabolomic study of substantial equivalence of field-grown genetically modified wheat. Plant Biotechnology Journal. 4 (4), pp. 381-392. https://doi.org/10.1111/j.1467-7652.2006.00197.x
Plant volatiles yielding new ways to exploit plant defence
B - Book chapters etc edited externally
Pickett, J. A., Bruce, T. J. A., Chamberlain, K., Hassanali, A., Khan, Z. R., Matthes, M. C., Napier, J. A., Smart, L. E., Wadhams, L. J. and Woodcock, C. M. 2006. Plant volatiles yielding new ways to exploit plant defence. in: Takken, W. and Dicke, M. (ed.) Chemical ecology: from gene to ecosystem Springer, Amsterdam. pp. 161-173
The alternative pathway C20 delta8-desaturase from the non-photosynthetic organism Acanthamoeba castellanii is an atypical cytochrome b5 -fusion desaturase
A - Papers appearing in refereed journals
Sayanova, O. V., Haslam, R. P., Qi, B., Lazarus, C. M. and Napier, J. A. 2006. The alternative pathway C20 delta8-desaturase from the non-photosynthetic organism Acanthamoeba castellanii is an atypical cytochrome b5 -fusion desaturase. FEBS Letters. 580 (8), pp. 1946-1952. https://doi.org/10.1016/j.febslet.2006.02.062
Members of the Arabidopsis FAE1-like 3-ketoacyl-CoA synthase gene family substitute for the Elop proteins of Saccharomyces cerevisiae
A - Papers appearing in refereed journals
Paul, S., Gable, K., Beaudoin, F., Cahoon, E., Jaworski, J., Napier, J. A. and Dunn, T. M. 2006. Members of the Arabidopsis FAE1-like 3-ketoacyl-CoA synthase gene family substitute for the Elop proteins of Saccharomyces cerevisiae. Journal of Biological Chemistry. 281, pp. 9018-9029. https://doi.org/10.1074/jbc.M507723200
Progress towards the production of very long-chain polyunsaturated fatty acid in transgenic plants: plant metabolic engineering comes of age
A - Papers appearing in refereed journals
Napier, J. A., Haslam, R. P., Venegas Caleron, M., Michaelson, L. V., Beaudoin, F. and Sayanova, O. V. 2006. Progress towards the production of very long-chain polyunsaturated fatty acid in transgenic plants: plant metabolic engineering comes of age. Physiologia Plantarum. 126 (3), pp. 398-406. https://doi.org/10.1111/j.1399-3054.2005.00603.x
Molecular analysis of a durum wheat 'stay green' mutant: expression pattern of photosynthesis-related genes
A - Papers appearing in refereed journals
Rampino, P., Spano, G., Pataleo, S., Mita, G., Napier, J. A., Di Fonzo, N., Shewry, P. R. and Perrotta, C. 2006. Molecular analysis of a durum wheat 'stay green' mutant: expression pattern of photosynthesis-related genes. Journal of Cereal Science. 43, pp. 160-168. https://doi.org/10.1016/j.jcs.2005.07.004
Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent EP 1576166 A2)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V., Lazarus, C. M, Qi, B., Heinz, E., Zank, T. and Zahringer, U. 2005. Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent EP 1576166 A2) . EP 1576166 A2
Semiochemical (Patent US 2005/0147635 A1)
H2 - Patents applied for
Hick, A. J., Pickett, J. A., Wadhams, L. J. and Napier, J. A. 2005. Semiochemical (Patent US 2005/0147635 A1). US 2005/0147635 A1
Desaturase Genes And Their Use (Patent US 6897050 B1)
H1 - Patents granted
Napier, J. A. 2005. Desaturase Genes And Their Use (Patent US 6897050 B1). US 6897050 B1
Semiochemical (Patent US 6890525 B2)
H1 - Patents granted
Hick, A. J., Pickett, J. A., Wadhams, L. J. and Napier, J. A. 2005. Semiochemical (Patent US 6890525 B2) . US 6890525 B2
Delta 6 Desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 2005/0089865 A1)
H2 - Patents applied for
Napier, J. A. and Sayanova, O. V. 2005. Delta 6 Desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 2005/0089865 A1). US 2005/0089865 A1
Elongase Gene And Production Of Delta9-polyunsaturated Fatty Acids (Patent US 2005/0089981 A1)
H2 - Patents applied for
Napier, J. A., Lazarus, C., Qi, B. and Lerchl, J. 2005. Elongase Gene And Production Of Delta9-polyunsaturated Fatty Acids (Patent US 2005/0089981 A1). US 2005/0089981 A1
Cis-jasmone As Semiochemical (Patent EP 1235483 B1)
H1 - Patents granted
Hick, A. J., Pickett, J. A., Wadhams, L. J. and Napier, J. A. 2005. Cis-jasmone As Semiochemical (Patent EP 1235483 B1) . EP 1235483 B1
The production of very-long-chain PUFA biosynthesis in transgenic plants: towards a sustainable source of fish oils
A - Papers appearing in refereed journals
Napier, J. A. and Sayanova, O. V. 2005. The production of very-long-chain PUFA biosynthesis in transgenic plants: towards a sustainable source of fish oils. Proceedings of the Nutrition Society. 64 (3), pp. 387-393. https://doi.org/10.1079/pns2005447
cis -Jasmone as an allelopathic agent through plant defence induction
C1 - Edited contributions to conferences/learned societies
Pickett, J. A., Birkett, M. A., Bruce, T. J. A., Chamberlain, K., Gordon-Weeks, R., Matthes, M. C., Moraes, C. B., Napier, J. A., Smart, L. E., Wadhams, L. J. and Woodcock, C. M. 2005. cis -Jasmone as an allelopathic agent through plant defence induction. Wu, H., Kent, J., Harper, J. and An, M. (ed.) Establishing the Scientific Base: Proceedings 4th World Congress on Allelopathy, Wagga Wagga, 21-26 August 2005 . Regional Institute, Gosford. pp. 122-127
Modification of the low molecular weight (LMW) glutenin composition of transgenic durum wheat: effects on glutenin polymer size and gluten functionality
A - Papers appearing in refereed journals
Tosi, P., Masci, S., Giovangrossi, A., D'ovidio, R., Bekes, F., Larroque, O., Napier, J. A. and Shewry, P. R. 2005. Modification of the low molecular weight (LMW) glutenin composition of transgenic durum wheat: effects on glutenin polymer size and gluten functionality. Molecular Breeding. 16, pp. 113-126.
Fatty acid desaturases from the microalga Thalassiosira pseudonana
A - Papers appearing in refereed journals
Tonon, T., Sayanova, O. V., Michaelson, L. V., Qing, R., Harvey, D., Larson, T. R., Li, Y., Napier, J. A. and Graham, I. A. 2005. Fatty acid desaturases from the microalga Thalassiosira pseudonana. The FEBS Journal. 272 (13), pp. 3401-3412. https://doi.org/10.1111/j.1742-4658.2005.04755.x
Plant FAE1-like condensing enzymes substiute for the Elop proteins in Saccharomyces cerevisiae
C2 - Non-edited contributions to conferences
Paul, S., Gable, K., Beaudoin, F., Napier, J. A. and Dunn, T. M. 2005. Plant FAE1-like condensing enzymes substiute for the Elop proteins in Saccharomyces cerevisiae.
Reverse engineering of long-chain polyunsaturated fatty acid biosynthesis into transgenic plants
A - Papers appearing in refereed journals
Napier, J. A., Beaudoin, F. and Sayanova, O. V. 2005. Reverse engineering of long-chain polyunsaturated fatty acid biosynthesis into transgenic plants. European Journal Of Lipid Science And Technology. 107 (4), pp. 249-255. https://doi.org/10.1002/ejlt.200590022
Analysis of detergent-resistant membranes in Arabidopsis. Evidence for plasma membrane lipid rafts
A - Papers appearing in refereed journals
Borner, G. H. H., Sherrier, D. J., Weimar, T., Michaelson, L. V., Hawkins, N. D., Macaskill, A., Napier, J. A., Beale, M. H., Lilley, K. S. and Dupree, P. 2005. Analysis of detergent-resistant membranes in Arabidopsis. Evidence for plasma membrane lipid rafts. Plant Physiology. 137 (1), pp. 104-116. https://doi.org/10.1104/pp.104.053041
Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1481063 A1)
H2 - Patents applied for
Napier, J. A. and Sayanova, O. V. 2004. Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1481063 A1) . EP 1481063 A1
Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent WO 2004/057001 A2)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V., Lazarus, C. M., Qi, B., Heinz, E., Zank, T. and Zahringer, U. 2004. Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent WO 2004/057001 A2) . WO 2004/057001 A2
Method For The Production Of Polyunsaturated Fatty Acids (Patent CA 2510462 A1)
H2 - Patents applied for
Heinz, E., Napier, J. A., Sayanova, O. V., Lazarus, C. M., Zahringer, U., Qi, B. and Zank, T. 2004. Method For The Production Of Polyunsaturated Fatty Acids (Patent CA 2510462 A1) . CA 2510462 A1
New Elongase Gene And Production Of Delta-9-polyunsaturated Fatty Acids (Patent EP 1373519 A2)
H2 - Patents applied for
Napier, J. A., Lazarus, C. M., Qi, B. and Lerchl, J. 2004. New Elongase Gene And Production Of Delta-9-polyunsaturated Fatty Acids (Patent EP 1373519 A2). EP 1373519 A2
The production of long chain polyunsaturated fatty acids in transgenic plants
B - Book chapters etc edited externally
Napier, J. A., Beaudoin, F., Michaelson, L. V. and Sayanova, O. V. 2004. The production of long chain polyunsaturated fatty acids in transgenic plants. in: Setlow, J. K. (ed.) Genetic engineering: principles and methods. Vol. 26 Springer, New York. pp. 143-157
Biosynthesis and compartmentation of triacylglycerol in higher plants
B - Book chapters etc edited externally
Beaudoin, F. and Napier, J. A. 2004. Biosynthesis and compartmentation of triacylglycerol in higher plants. in: Daum, G. (ed.) Lipid metabolism and membrane biogenesis Springer, New York. pp. 267-287
Production of long-chain polyunsaturated fatty acids in transgenic plants: a sustainable source for human health and nutrition
G - Articles in popular magazines and other technical publications
Napier, J. A. 2004. Production of long-chain polyunsaturated fatty acids in transgenic plants: a sustainable source for human health and nutrition. Lipid Technology. 16, pp. 103-107.
Progress toward the production of long-chain polyunsaturated fatty acids in transgenic plants
A - Papers appearing in refereed journals
Napier, J. A., Sayanova, O. V., Qi, B. and Lazarus, C. M. 2004. Progress toward the production of long-chain polyunsaturated fatty acids in transgenic plants. Lipids. 39, pp. 1067-1075.
The use of very long chain polyunsaturated fatty acids to ameliorate metabolic syndrome: transgenic plants as an alternative sustainable source to fish oils
A - Papers appearing in refereed journals
Graham, I. A., Cirpus, P., Rein, D. and Napier, J. A. 2004. The use of very long chain polyunsaturated fatty acids to ameliorate metabolic syndrome: transgenic plants as an alternative sustainable source to fish oils. Nutrition Bulletin. 29, pp. 228-233.
The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering
A - Papers appearing in refereed journals
Napier, J. A., Beaudoin, F., Michaelson, L. V. and Sayanova, O. V. 2004. The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering. Biochimie. 86, pp. 785-793.
Biosynthesis of very-long-chain polyunsaturated fatty acids in transgenic oilseeds: constraints on their accumulation
A - Papers appearing in refereed journals
Abbadi, A., Domergue, F., Bauer, J., Napier, J. A., Welti, R., Zahringer, U., Cirpus, P. and Heinz, E. 2004. Biosynthesis of very-long-chain polyunsaturated fatty acids in transgenic oilseeds: constraints on their accumulation. The Plant Cell. 16, pp. 2734-2748.
Isolation and expression pattern of two putative acyl-ACP desaturase cDNAs for Bassia scoparia
A - Papers appearing in refereed journals
Whitney, H. M., Sayanova, O. V., Pickett, J. A. and Napier, J. A. 2004. Isolation and expression pattern of two putative acyl-ACP desaturase cDNAs for Bassia scoparia. Journal of Experimental Botany. 55, pp. 787-789.
Eicosapentaenoic acid: biosynthesis routes and the potential for synthesis in transgenic plants
A - Papers appearing in refereed journals
Sayanova, O. V. and Napier, J. A. 2004. Eicosapentaenoic acid: biosynthesis routes and the potential for synthesis in transgenic plants. Phytochemistry. 65, pp. 147-158.
Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants
A - Papers appearing in refereed journals
Qi, B., Fraser, T., Mugford, S., Dobson, G., Sayanova, O. V., Butler, J., Napier, J. A., Stobart, A. K. and Lazarus, C. M. 2004. Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants. Nature Biotechnology. 22 (6), pp. 739-745. https://doi.org/10.1038/nbt972
Genetic manipulation of gamma-linolenic acid (GLA) synthesis in a commercial variety of evening primrose (Oenothera sp.)
A - Papers appearing in refereed journals
Mendoza De Gyves, E., Sparks, C. A., Sayanova, O. V., Lazzeri, P. A., Napier, J. A. and Jones, H. D. 2004. Genetic manipulation of gamma-linolenic acid (GLA) synthesis in a commercial variety of evening primrose (Oenothera sp.). Plant Biotechnology Journal. 2 (4), pp. 351-357. https://doi.org/10.1111/j.1467-7652.2004.00079.x
Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system
A - Papers appearing in refereed journals
Gable, K., Garton, S., Napier, J. A. and Dunn, T. M. 2004. Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system. Journal of Experimental Botany. 55, pp. 543-535.
A post-genomic approach to understanding sphingolipid metabolism in Arabidopsis thaliana
A - Papers appearing in refereed journals
Dunn, T. M., Lynch, D. V., Michaelson, L. V. and Napier, J. A. 2004. A post-genomic approach to understanding sphingolipid metabolism in Arabidopsis thaliana. Annals of Botany. 93, pp. 483-497.
Transgenic expression of epitope-tagged LMW glutenin subunits in durum wheat: effect on polymer size distribution and dough mixing properties
C1 - Edited contributions to conferences/learned societies
Tosi, P., Bekes, F., Napier, J. A. and Shewry, P. R. 2004. Transgenic expression of epitope-tagged LMW glutenin subunits in durum wheat: effect on polymer size distribution and dough mixing properties. D'ovidio, R., Lafiandra, D. and Masci, S. (ed.) Gluten Proteins. Proceedings 8th Gluten Workshop, Viterbo, 8-10 September 2003 . Royal Society of Chemistry (RSC), Cambridge. pp. 22-25
Expression of epitope-tagged LMW glutenin subunits in the starchy endosperm of transgenic wheat and their incorporation into glutenin polymers
A - Papers appearing in refereed journals
Tosi, P., D'ovidio, R., Napier, J. A., Bekes, F. and Shewry, P. R. 2004. Expression of epitope-tagged LMW glutenin subunits in the starchy endosperm of transgenic wheat and their incorporation into glutenin polymers. Theoretical and Applied Genetics. 108, pp. 468-476.
Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent WO 2003/072784 A1)
H2 - Patents applied for
Napier, J. A. 2003. Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent WO 2003/072784 A1). WO 2003/072784 A1
Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent CA 2476041 A1)
H2 - Patents applied for
Napier, J. A. and Sayanova, O. V. 2003. Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent CA 2476041 A1). CA 2476041 A1
Delta 6-desaturases From Primulaceae (Patent GB 2385852 A)
H2 - Patents applied for
Napier, J. A. and Sayanova, O. V. 2003. Delta 6-desaturases From Primulaceae (Patent GB 2385852 A) . GB 2385852 A
Desaturase (Patent US 2003/0152983 A1)
H2 - Patents applied for
Napier, J. A., Michaelson, L. V. and Stobart, K. 2003. Desaturase (Patent US 2003/0152983 A1). US 2003/0152983 A1
Semiochemical (Patent US 2003/0109586 A1)
H2 - Patents applied for
Pickett, J. A., Wadhams, L. J., Hick, A. J. and Napier, J. A. 2003. Semiochemical (Patent US 2003/0109586 A1). US 2003/0109586 A1
Molecular analysis of "stay green" mutants in durum wheat
C2 - Non-edited contributions to conferences
Rampino, P., Spano, G., Trono, D., Di Fonzo, N., Shewry, P. R., Napier, J. A. and Perrotta, C. 2003. Molecular analysis of "stay green" mutants in durum wheat. Proceedings 10th International Wheat Genetics Symposium, Paestum, Italy, 1-6 September 2003. Vol. 2 - Poster Presentations . pp. 905-907
Production of high value chemicals in plants
B - Book chapters etc edited externally
Beale, M. H. and Napier, J. A. 2003. Production of high value chemicals in plants. in: Shewry, P. R., Lenton, J. R. and Anderson, H. M. (ed.) Long Ashton Research Station: one hundred years of science in support of agriculture Institute for Arable Crops Research (IACR) , Long Ashton Research Station (LARS), Bristol. pp. 284-290
Expression of the gamma-zein protein of maize in seeds of transgenic barley: effects on grain composition and properties
A - Papers appearing in refereed journals
Zhang, Y., Darlington, H., Jones, H. D., Halford, N. G., Napier, J. A., Davey, M. R., Lazzeri, P. A. and Shewry, P. R. 2003. Expression of the gamma-zein protein of maize in seeds of transgenic barley: effects on grain composition and properties. Theoretical and Applied Genetics. 106 (6), pp. 1139-1146. https://doi.org/10.1007/s00122-002-1162-3
TaqMan PCR for detection of genetically modified durum wheat
A - Papers appearing in refereed journals
Terzi, V., Ferrari, B., Finocchiaro, F., Di Fonzo, N., Stanca, A. M., Lamacchia, C., Napier, J. A., Shewry, P. R. and Faccioli, P. 2003. TaqMan PCR for detection of genetically modified durum wheat. Journal of Cereal Science. 37, pp. 157-163.
Identification of Primula fatty acid delta6-desaturases with n-3 substrate preferences
A - Papers appearing in refereed journals
Sayanova, O. V., Beaudoin, F., Michaelson, L. V., Shewry, P. R. and Napier, J. A. 2003. Identification of Primula fatty acid delta6-desaturases with n-3 substrate preferences. FEBS Letters. 542 (1-3), pp. 100-104. https://doi.org/10.1016/S0014-5793(03)00358-2
The role of cytochrome b 5 fusion desaturases in the synthesis of polyunsaturated fatty acids
A - Papers appearing in refereed journals
Napier, J. A., Michaelson, L. V. and Sayanova, O. V. 2003. The role of cytochrome b 5 fusion desaturases in the synthesis of polyunsaturated fatty acids. Prostaglandins, Leukotrienes and Essential Fatty Acids. 68 (2), pp. 135-143. https://doi.org/10.1016/S0952-3278(02)00263-6
The dihydroceramide desaturase is not essential for cell viability in Schizosaccharomyces pombe
A - Papers appearing in refereed journals
Garton, S., Michaelson, L. V., Beaudoin, F., Beale, M. H. and Napier, J. A. 2003. The dihydroceramide desaturase is not essential for cell viability in Schizosaccharomyces pombe. FEBS Letters. 538, pp. 192-196.
New lipid-derived signals in plants and their role in modulating gene expression
C2 - Non-edited contributions to conferences
Matthes, M. C., Michaelson, L. V., Beaudoin, F., Garton, S., Pickett, J. A. and Napier, J. A. 2003. New lipid-derived signals in plants and their role in modulating gene expression.
Physiological characterization of 'stay green' mutants in durum wheat
A - Papers appearing in refereed journals
Spano, G., Di Fonzo, N., Perrotta, C., Platani, C., Ronga, G., Lawlor, D. W., Napier, J. A. and Shewry, P. R. 2003. Physiological characterization of 'stay green' mutants in durum wheat. Journal of Experimental Botany. 54, pp. 1415-1420. https://doi.org/10.1093/jxb/erg150
Functional characterisation of two cytochrome b 5-fusion desaturases from Anemone leveillei : the unexpected identification of a fatty acid delta6-desaturase
A - Papers appearing in refereed journals
Whitney, H. M., Michaelson, L. V., Sayanova, O. V., Pickett, J. A. and Napier, J. A. 2003. Functional characterisation of two cytochrome b 5-fusion desaturases from Anemone leveillei : the unexpected identification of a fatty acid delta6-desaturase. Planta. 217 (6), pp. 983-992. https://doi.org/10.1007/s00425-003-1069-5
New chemical signals in plant protection against herbivores and weeds
C1 - Edited contributions to conferences/learned societies
Matthes, M. C., Napier, J. A., Pickett, J. A. and Woodcock, C. M. 2003. New chemical signals in plant protection against herbivores and weeds. Proceedings BCPC International Congress - Crop Science and Technology, Glasgow, 10-12 November 2003 . pp. 1227-1236
Plant stress signalling: understanding and exploiting plant-plant interactions
A - Papers appearing in refereed journals
Pickett, J. A., Rasmussen, H. B., Woodcock, C. M., Matthes, M. C. and Napier, J. A. 2003. Plant stress signalling: understanding and exploiting plant-plant interactions. Biochemical Society Transactions. 31 (1), pp. 123-127. https://doi.org/10.1042/bst0310123
New Elongase Gene And Production Of Δ9-polyunsaturated Fatty Acids (Patent WO 2002/077213 A2)
H2 - Patents applied for
Napier, J. A., Lazarus, C. M., Qi, B. and Lerchl, J. 2002. New Elongase Gene And Production Of Δ9-polyunsaturated Fatty Acids (Patent WO 2002/077213 A2). WO 2002/077213 A2
New Elongase Gene And Production Of Delta 9-polyunsaturated Fatty Acids (Patent CA 2442010 A1)
H2 - Patents applied for
Qi, B, Lerchl, J., Lazarus, C. M. and Napier, J. A. 2002. New Elongase Gene And Production Of Delta 9-polyunsaturated Fatty Acids (Patent CA 2442010 A1). CA 2442010 A1
Cis-jasmone As Semiochemical (Patent EP 1235483 A2)
H1 - Patents granted
Hick, A. J., Pickett, J. A., Wadhams, L. J. and Napier, J. A. 2002. Cis-jasmone As Semiochemical (Patent EP 1235483 A2). EP 1235483 A2
Polysaturated Fatty Acid (pufa) Elongase From Caenorhabditis Elegans (Patent WO 2000/055330 A9)
H2 - Patents applied for
Napier, J. A. 2002. Polysaturated Fatty Acid (pufa) Elongase From Caenorhabditis Elegans (Patent WO 2000/055330 A9). WO 2000/055330 A9
Identification of a cDNA encoding a novel C18-delta9 polyunsaturated fatty acid-specific elongating activity from the docosahexaenoic acid (DHA)-producing microalga, Isochrysis galbana
A - Papers appearing in refereed journals
Qi, B., Beaudoin, F., Fraser, T., Stobart, A. K., Napier, J. A. and Lazarus, C. M. 2002. Identification of a cDNA encoding a novel C18-delta9 polyunsaturated fatty acid-specific elongating activity from the docosahexaenoic acid (DHA)-producing microalga, Isochrysis galbana. FEBS Letters. 510 (3), pp. 159-165. https://doi.org/10.1016/S0014-5793(01)03247-1
The production of polyunsaturated fatty acids in transgenic plants
A - Papers appearing in refereed journals
Napier, J. A. 2002. The production of polyunsaturated fatty acids in transgenic plants. Inform - International News on Fats, Oils and Related Materials. 13, pp. 769-772.
A new class of lipid desaturase central to sphingolipid biosynthesis and signalling
A - Papers appearing in refereed journals
Napier, J. A., Michaelson, L. V. and Dunn, T. M. 2002. A new class of lipid desaturase central to sphingolipid biosynthesis and signalling. Trends in Plant Science. 7, pp. 475-478.
Plumbing the depths of PUFA biosynthesis: a novel polyketide synthase-like pathway from marine organisms
A - Papers appearing in refereed journals
Napier, J. A. 2002. Plumbing the depths of PUFA biosynthesis: a novel polyketide synthase-like pathway from marine organisms. Trends in Plant Science. 7, pp. 51-54.
Altering specifity of a Ricinus communis cytochrome b5 fusion desaturase
A - Papers appearing in refereed journals
Michaelson, L. V. and Napier, J. A. 2002. Altering specifity of a Ricinus communis cytochrome b5 fusion desaturase. Biochemical Society Transactions. 30 (5), p. A123. https://doi.org/10.1042/bst030a123a
Isolation and characterization of a cDNA encoding a delta8 sphingolipid desaturase from Aquilegia vulgaris
A - Papers appearing in refereed journals
Michaelson, L. V., Longman, A. J., Sayanova, O. V., Stobart, A. K. and Napier, J. A. 2002. Isolation and characterization of a cDNA encoding a delta8 sphingolipid desaturase from Aquilegia vulgaris. Biochemical Society Transactions. 30 (6), pp. 1073-1075. https://doi.org/10.1042/bst0301073
The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase
A - Papers appearing in refereed journals
Han, G., Gable, K., Kohlwein, S. D., Beaudoin, F., Napier, J. A. and Dunn, T. M. 2002. The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase. Journal of Biological Chemistry. 277, pp. 35440-35449. https://doi.org/10.1074/jbc.M205620200
A new class of lipid desaturases: identification of the delta4 sphingoid base desaturase
A - Papers appearing in refereed journals
Garton, S., Michaelson, L. V., Beaudoin, F. and Napier, J. A. 2002. A new class of lipid desaturases: identification of the delta4 sphingoid base desaturase. Biochemical Society Transactions. 30 (6), p. A122. https://doi.org/10.1042/bst030a122c
Targeting and membrane-insertion of a sunflower oleosin in vitro and in Saccharomyces cerevisiae : the central hydrophobic domain contains more than one signal sequence, and directs oleosin insertion into the endoplasmic reticulum membrane using a signal anchor sequence mechanism
A - Papers appearing in refereed journals
Beaudoin, F. and Napier, J. A. 2002. Targeting and membrane-insertion of a sunflower oleosin in vitro and in Saccharomyces cerevisiae : the central hydrophobic domain contains more than one signal sequence, and directs oleosin insertion into the endoplasmic reticulum membrane using a signal anchor sequence mechanism. Planta. 215, pp. 293-303.
A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase
A - Papers appearing in refereed journals
Beaudoin, F., Gable, K., Sayanova, O. V., Dunn, T. and Napier, J. A. 2002. A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase. Journal of Biological Chemistry. 277, pp. 11481-11488.
Characterization and modelling of the hydrophobic domain of a sunflower oleosin
A - Papers appearing in refereed journals
Alexander, L. G., Sessions, R. B., Clarke, A. R., Tatham, A. S., Shewry, P. R. and Napier, J. A. 2002. Characterization and modelling of the hydrophobic domain of a sunflower oleosin. Planta. 214, pp. 546-551.
Semiochemical (Patent WO 2001/041568 A2)
H2 - Patents applied for
Hick, A. J., Pickett, J. A., Wadhams, L .J. and Napier, J. A. 2001. Semiochemical (Patent WO 2001/041568 A2) . WO 2001/041568 A2
Semiochemical (Patent CA 2388964 A1)
H2 - Patents applied for
Pickett, J. A., Wadhams, L. J., Hick, A. J. and Napier, J. A. 2001. Semiochemical (Patent CA 2388964 A1) . CA 2388964 A1
The production of gamma-linolenic acid in transgenic plants: further studies on the borage delta6-fatty acid desaturase
C1 - Edited contributions to conferences/learned societies
Sayanova, O. V., Beaudoin, F., Libisch, B., Shewry, P. R. and Napier, J. A. 2001. The production of gamma-linolenic acid in transgenic plants: further studies on the borage delta6-fatty acid desaturase. Huang, Y. S. and Ziboh, A. (ed.) Gamma-linolenic acid: recent advances in biotechnology and clinical applications . American Oil Chemists' Society (AOCS) Press, Champaign, Illinois. pp. 24-28
Genetic modification of the trafficking and deposition of seed storage proteins to alter dough functional properties
C1 - Edited contributions to conferences/learned societies
Lamacchia, C., Di Fonzo, N., Harris, N., Richardson, A. C., Napier, J. A., Lazzeri, P. A. and Barcelo, P. 2001. Genetic modification of the trafficking and deposition of seed storage proteins to alter dough functional properties. Shewry, P. R. and Tatham, A. S. (ed.) Wheat Gluten. Proceedings 7th International Workshop Gluten 2000, Bristol, 2-6 April 2000 . Royal Society of Chemistry (RSC), Cambridge. pp. 97-100
Characterization of a monoclonal antibody that recognises a specific group of LMW subunits of glutenin
C1 - Edited contributions to conferences/learned societies
Hey, S., Napier, J. A., Mills, C., Brett, G., Hook, S. and Fido, R. J. 2001. Characterization of a monoclonal antibody that recognises a specific group of LMW subunits of glutenin. Shewry, P. R. and Tatham, A. S. (ed.) Wheat Gluten. Proceedings 7th International Workshop Gluten 2000, Bristol, 2-6 April 2000 . Royal Society of Chemistry (RSC), Cambridge. pp. 192-195
Mutagenesis and heterologous expression in yeast of a plant delta6-fatty acid desaturase
A - Papers appearing in refereed journals
Sayanova, O. V., Beaudoin, F., Libisch, B., Castel, A., Shewry, P. R. and Napier, J. A. 2001. Mutagenesis and heterologous expression in yeast of a plant delta6-fatty acid desaturase. Journal of Experimental Botany. 52, pp. 1581-1585.
The seed oleosins: structure, properties and biological role
A - Papers appearing in refereed journals
Napier, J. A., Beaudoin, F., Tatham, A. S., Alexander, L. G. and Shewry, P. R. 2001. The seed oleosins: structure, properties and biological role. Advances in botanical research. 35, pp. 111-138. https://doi.org/10.1016/S0065-2296(01)35005-X
Towards the production of pharmaceutical fatty acids in transgenic plants
A - Papers appearing in refereed journals
Napier, J. A. and Michaelson, L. V. 2001. Towards the production of pharmaceutical fatty acids in transgenic plants. Journal of the Science of Food and Agriculture. 81, pp. 883-888.
Genomic and functional characterization of polyunsaturated fatty acid biosynthesis in Caenorhabditis elegans
A - Papers appearing in refereed journals
Napier, J. A. and Michaelson, L. V. 2001. Genomic and functional characterization of polyunsaturated fatty acid biosynthesis in Caenorhabditis elegans. Lipids. 36, pp. 761-766.
Modification of the LMW glutenin subunit composition of durum wheat by microprojectile-mediated transformation
C1 - Edited contributions to conferences/learned societies
Tosi, P., Napier, J. A., D'ovidio, R. and Jones, H. D. 2001. Modification of the LMW glutenin subunit composition of durum wheat by microprojectile-mediated transformation. Shewry, P. R. and Tatham, A. S. (ed.) Wheat Gluten. Proceedings 7th International Workshop Gluten 2000, Bristol, 2-6 April 2000 . Royal Society of Chemistry (RSC), Cambridge. pp. 93-96
Improvement of wheat processing quality by genetic engineering
C1 - Edited contributions to conferences/learned societies
Jones, H. D., Pastori, G. M., Rooke, L., Steele, S. H., He, G. Y., Tosi, P., D'ovidio, R., Bekes, F., Darlington, H., Napier, J. A., Fido, R., Barcelo, P. and Lazzeri, P. A. 2001. Improvement of wheat processing quality by genetic engineering. Shewry, P. R. and Tatham, A. S. (ed.) Wheat Gluten. Proceedings 7th International Workshop Gluten 2000, Bristol, 2-6 April 2000 . Royal Society of Chemistry (RSC), Cambridge. pp. 73-76
Functional identification of a delta8-sphingolipid desaturase from Borago officinalis
A - Papers appearing in refereed journals
Sperling, P., Libisch, B., Zahringer, U., Napier, J. A. and Heinz, E. 2001. Functional identification of a delta8-sphingolipid desaturase from Borago officinalis. Archives of Biochemistry and Biophysics. 388 (2), pp. 293-298. https://doi.org/10.1006/abbi.2001.2308
Endosperm-specific activity of a storage protein gene promoter in transgenic wheat seed
A - Papers appearing in refereed journals
Lamacchia, C., Shewry, P. R., Di Fonzo, N., Forsyth, J. L., Harris, N., Lazzeri, P. A., Napier, J. A., Halford, N. G. and Barcelo, P. 2001. Endosperm-specific activity of a storage protein gene promoter in transgenic wheat seed. Journal of Experimental Botany. 52, pp. 243-250.
Expression of HMW subunit, gamma-zein and uidA genes in endosperms of transgenic bread wheat
C1 - Edited contributions to conferences/learned societies
He, G. Y., D'ovidio, R., Anderson, O. D., Fido, R. J., Tatham, A. S., Darlington, H. F., Napier, J. A., Lazzeri, P. A., Jones, H. D. and Shewry, P. R. 2001. Expression of HMW subunit, gamma-zein and uidA genes in endosperms of transgenic bread wheat. Lang, L. and Bedo, Z. (ed.) Wheat in a Global Environment: Proceedings 6th International Wheat Conference, Budapest, 5-9 June 2000 . Kluwer Academic Publishers, Dordrecht, Netherlands. pp. 177-181
Desaturase (Patent EP 1042485 A2)
H2 - Patents applied for
Napier, J. A., Michaelson, L. V. and Stobart, K. 2000. Desaturase (Patent EP 1042485 A2). EP 1042485 A2
Polysaturated Fatty Acid (pufa) Elongase From Caenorhabditis Elegans (Patent WO 2000/055330 A1)
H2 - Patents applied for
Napier, J. A. 2000. Polysaturated Fatty Acid (pufa) Elongase From Caenorhabditis Elegans (Patent WO 2000/055330 A1). WO 2000/055330 A1
Polyunsaturated Fatty Acid (pufa) Elongase From Caenorhabditis Elegans (Patent CA 2365096 A1)
H2 - Patents applied for
Napier, J. A. 2000. Polyunsaturated Fatty Acid (pufa) Elongase From Caenorhabditis Elegans (Patent CA 2365096 A1) . CA 2365096 A1
Desaturase Genes And Their Use (Patent EP 1032682 A1)
H2 - Patents applied for
Napier, J. A. 2000. Desaturase Genes And Their Use (Patent EP 1032682 A1). EP 1032682 A1
The targeting and accumulation of ectopically expressed oleosin in non-seed tissues of Arabidopsis thaliana
A - Papers appearing in refereed journals
Beaudoin, F. and Napier, J. A. 2000. The targeting and accumulation of ectopically expressed oleosin in non-seed tissues of Arabidopsis thaliana. Planta. 210 (3), pp. 439-445. https://doi.org/10.1007/pl00008152
In vivo targeting of a sunflower oil body protein in yeast secretory (sec) mutants
A - Papers appearing in refereed journals
Beaudoin, F., Wilkinson, B. M., Stirling, C. J. and Napier, J. A. 2000. In vivo targeting of a sunflower oil body protein in yeast secretory (sec) mutants. The Plant Journal. 23 (2), pp. 159-170. https://doi.org/10.1046/j.1365-313x.2000.00769.x
Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway
A - Papers appearing in refereed journals
Beaudoin, F., Michaelson, L. V., Hey, S. J., Lewis, M. J., Shewry, P. R., Sayanova, O. V. and Napier, J. A. 2000. Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway. Proceedings of the National Academy of Sciences. 97 (12), pp. 6421-6426. https://doi.org/10.1073/pnas.110140197
Overexpression, purification and in vitro refolding of the 11S globulin from amaranth seed in Escherichia coli
A - Papers appearing in refereed journals
Osuna-Castro, J. A., Rascon-Cruz, Q., Napier, J. A., Fido, R. J., Shewry, P. R. and Paredes-Lopez, O. 2000. Overexpression, purification and in vitro refolding of the 11S globulin from amaranth seed in Escherichia coli. Journal of Agricultural and Food Chemistry - JAFC. 48, pp. 5249-5255.
Isolation of two putative acyl-acyl carrier protein desaturase enzymes from Kochia scoparia
A - Papers appearing in refereed journals
Whitney, H., Sayanova, O. V., Lewis, M. J., Pickett, J. A. and Napier, J. A. 2000. Isolation of two putative acyl-acyl carrier protein desaturase enzymes from Kochia scoparia. Biochemical Society Transactions. 28 (6), pp. 623-624. https://doi.org/10.1042/bst0280623
Mutagenesis of the borage delta 6 fatty acid desaturase
A - Papers appearing in refereed journals
Sayanova, O. V., Beaudoin, F., Libisch, B., Shewry, P. R. and Napier, J. A. 2000. Mutagenesis of the borage delta 6 fatty acid desaturase. Biochemical Society Transactions. 28 (6), pp. 636-638. https://doi.org/10.1042/bst0280636
An unusual desaturase in Aquilegia vulgaris
A - Papers appearing in refereed journals
Longman, A. J., Michaelson, L. V., Sayanova, O. V., Napier, J. A. and Stobart, A. K. 2000. An unusual desaturase in Aquilegia vulgaris. Biochemical Society Transactions. 28 (6), pp. 641-643. https://doi.org/10.1042/bst0280641
Chimeras of delta6-fatty acid and delta8-sphingolipid desaturases
A - Papers appearing in refereed journals
Libisch, B., Michaelson, L. V., Lewis, M. J., Shewry, P. R. and Napier, J. A. 2000. Chimeras of delta6-fatty acid and delta8-sphingolipid desaturases. Biochemical and Biophysical Research Communications. 279 (3), pp. 779-785. https://doi.org/10.1006/bbrc.2000.4023
Production of C20 polyunsaturated fatty acids (PUFAs) by pathway engineering: identification of a PUFA elongase component from Caenorhabditis elegans
A - Papers appearing in refereed journals
Beaudoin, F., Michaelson, L. V., Lewis, M. J., Shewry, P. R., Sayanova, O. V. and Napier, J. A. 2000. Production of C20 polyunsaturated fatty acids (PUFAs) by pathway engineering: identification of a PUFA elongase component from Caenorhabditis elegans. Biochemical Society Transactions. 28 (6), pp. 661-663. https://doi.org/10.1042/bst0280661
Improvement of durum wheat quality by genetic engineering
C1 - Edited contributions to conferences/learned societies
Shewry, P. R., Tosi, P., He, G. Y., Lamacchia, C., Di Fonzo, N., D'ovidio, R., Jones, H. D., Bell, P., Barcelo, P., Napier, J. A., Halford, N. G. and Lazzeri, P. A. 2000. Improvement of durum wheat quality by genetic engineering. Proceedings International Workshop on Durum Wheat, Semolina and Pasta Quality: Recent Achievements and New Trends, Montpellier, 27 November 2000 . pp. 9-15
Expression of gamma-zein, a maize storage protein gene, in barley seed
C1 - Edited contributions to conferences/learned societies
Zhang, Y., Darlington, H., Napier, J. A., Jones, H. D., Davey, M. R., Halford, N. G., Lazzeri, P. A. and Shewry, P. R. 2000. Expression of gamma-zein, a maize storage protein gene, in barley seed. Barley Genetics VIII,Proceedings 8th International Barley Genetics Symposium, Adelaide, October 2000 Vol. 3. pp. 131-133
Transgenic plants for the production of pharmaceutical fatty acids
A - Papers appearing in refereed journals
Napier, J. A. 2000. Transgenic plants for the production of pharmaceutical fatty acids. Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz. 43, pp. 99-103.
New roles for cis-jasmone as an insect semiochemical and in plant defense
A - Papers appearing in refereed journals
Birkett, M. A., Campbell, C. A. M., Chamberlain, K., Guerrieri, E., Hick, A. J., Martin, J. L., Matthes, M. C., Napier, J. A., Pettersson, J., Pickett, J. A., Poppy, G. M., Pow, E. M., Pye, B. J., Smart, L. E., Wadhams, G. H., Wadhams, L. J. and Woodcock, C. M. 2000. New roles for cis-jasmone as an insect semiochemical and in plant defense. Proceedings of the National Academy of Sciences. 97 (16), pp. 9329-9334. https://doi.org/10.1073/pnas.160241697
Desaturase (Patent WO 1999/033958 A2 )
H2 - Patents applied for
Napier, J. A., Michaelson, L. V. and Stobart, K. 1999. Desaturase (Patent WO 1999/033958 A2 ) . WO 1999/033958 A2
Desaturase Genes And Their Use (Patent WO 1999/027111 A1)
H2 - Patents applied for
Napier, J. A. 1999. Desaturase Genes And Their Use (Patent WO 1999/027111 A1). WO 1999/027111 A1
Desaturase Genes And Their Use (Patent CA 2311472 A1)
H2 - Patents applied for
Napier, J. A. 1999. Desaturase Genes And Their Use (Patent CA 2311472 A1). CA 2311472 A1
The localization and expression of the class II starch synthases of wheat
A - Papers appearing in refereed journals
Li, Z. Y., Chu, X. S., Mouille, G., Yan, L. L., Kosar-Hashemi, B., Hey, S., Napier, J. A., Shewry, P. R., Clarke, B., Appels, R., Morell, M. K. and Rahman, S. 1999. The localization and expression of the class II starch synthases of wheat. Plant Physiology. 120 (4), pp. 1147-1155. https://doi.org/10.1104/pp.120.4.1147
The biogenesis of the plant seed oil body: Oleosin protein is synthesised by ER-bound ribosomes
A - Papers appearing in refereed journals
Beaudoin, F., Lacey, D. J. and Napier, J. A. 1999. The biogenesis of the plant seed oil body: Oleosin protein is synthesised by ER-bound ribosomes. Plant Physiology and Biochemistry. 37 (6), pp. 481-490. https://doi.org/10.1016/s0981-9428(99)80053-9
The accumulation of triacylglycerols within the endoplasmic reticulum of developing seeds of Helianthus annuus
A - Papers appearing in refereed journals
Lacey, D. J., Beaudoin, F., Dempsey, C. E., Shewry, P. R. and Napier, J. A. 1999. The accumulation of triacylglycerols within the endoplasmic reticulum of developing seeds of Helianthus annuus. The Plant Journal. 17 (4), pp. 397-405. https://doi.org/10.1046/j.1365-313X.1999.00387.x
Plant desaturases: harvesting the fat of the land
A - Papers appearing in refereed journals
Napier, J. A., Michaelson, L. V. and Stobart, A. K. 1999. Plant desaturases: harvesting the fat of the land. Current Opinion in Plant Biology. 2 (2), pp. 123-127. https://doi.org/10.1016/s1369-5266(99)80025-9
Histidine-41 of the cytochrome b(5) domain of the borage Delta(6) fatty acid desaturase is essential for enzyme activity
A - Papers appearing in refereed journals
Sayanova, O. V., Shewry, P. R. and Napier, J. A. 1999. Histidine-41 of the cytochrome b(5) domain of the borage Delta(6) fatty acid desaturase is essential for enzyme activity. Plant Physiology. 121 (2), pp. 641-646. https://doi.org/10.1104/pp.121.2.641
Delta(6)-Unsaturated fatty acids in species and tissues of the Primulaceae
A - Papers appearing in refereed journals
Sayanova, O. V., Napier, J. A. and Shewry, P. R. 1999. Delta(6)-Unsaturated fatty acids in species and tissues of the Primulaceae. Phytochemistry. 52 (3), pp. 419-422. https://doi.org/10.1016/s0031-9422(99)00256-3
Characterization and expression of a fatty acid desaturase from Borago officinalis
A - Papers appearing in refereed journals
Sayanova, O. V., Shewry, P. R. and Napier, J. A. 1999. Characterization and expression of a fatty acid desaturase from Borago officinalis. Journal of Experimental Botany. 50 (332), pp. 411-412. https://doi.org/10.1093/jxb/50.332.411
Accumulation of Delta(6)-unsaturated fatty acids in transgenic tobacco plants expressing a Delta(6)-desaturase from Borago officinalis
A - Papers appearing in refereed journals
Sayanova, O. V., Davies, G. M., Smith, M. A., Griffiths, G., Stobart, A. K., Shewry, P. R. and Napier, J. A. 1999. Accumulation of Delta(6)-unsaturated fatty acids in transgenic tobacco plants expressing a Delta(6)-desaturase from Borago officinalis. Journal of Experimental Botany. 50 (340), pp. 1647-1652. https://doi.org/10.1093/jxb/50.340.1647
A growing family of cytochrome b(5)-domain fusion proteins
A - Papers appearing in refereed journals
Napier, J. A., Sayanova, O. V., Sperling, P. and Heinz, E. 1999. A growing family of cytochrome b(5)-domain fusion proteins. Trends in Plant Science. 4 (1), pp. 2-4. https://doi.org/10.1016/s1360-1385(98)01357-0
Genetic manipulation of seed composition in barley
C2 - Non-edited contributions to conferences
Zhang, Y., Darlington, H., Napier, J. A., Jones, H. D., Davey, M. R., Shewry, P. R., Halford, N. G. and Lazzeri, P. A. 1999. Genetic manipulation of seed composition in barley. Abstracts 16th Long Ashton International Symposium on Biotechnology of Cereals: Tools, Targets and Triumphs, Long Ashton, 13-15 September 1999 .
Transformation of durum wheat to alter dough functional properties and explore the trafficking and deposition of gluten proteins
C2 - Non-edited contributions to conferences
He, G., Lamacchia, C., Rooke, L., Tatham, A. S., Fido, R., Bekes, F., Gras, P., Harris, N., Di Fonzo, N., Deambrogio, E., Barcelo, P., Shewry, P. R., Napier, J. A. and Lazzeri, P. A. 1999. Transformation of durum wheat to alter dough functional properties and explore the trafficking and deposition of gluten proteins. Oxford University Press (OUP) Oxford.
Improving plant product quality
A - Papers appearing in refereed journals
Miflin, B. J., Napier, J. A. and Shewry, P. R. 1999. Improving plant product quality. Nature Biotechnology. 17 (2s), pp. BV13-BV14. https://doi.org/10.1038/7155
Synthesis of storage reserves in developing seeds of sunflower
A - Papers appearing in refereed journals
Mazhar, H., Quayle, R., Fido, R. J., Stobart, A. K., Napier, J. A. and Shewry, P. R. 1998. Synthesis of storage reserves in developing seeds of sunflower. Phytochemistry. 48 (3), pp. 429-432. https://doi.org/10.1016/s0031-9422(98)00009-0
Secondary structure of oleosins in oil bodies isolated from seeds of safflower (Carthamus tinctorius L.) and sunflower (Helianthus annuus L.)
A - Papers appearing in refereed journals
Lacey, D. J., Wellner, N., Beaudoin, F., Napier, J. A. and Shewry, P. R. 1998. Secondary structure of oleosins in oil bodies isolated from seeds of safflower (Carthamus tinctorius L.) and sunflower (Helianthus annuus L.). Biochemical Journal. 334, pp. 469-477.
Isolation of a Delta(5)-fatty acid desaturase gene from Mortierella alpina
A - Papers appearing in refereed journals
Michaelson, L. V., Lazarus, C. M., Griffiths, G., Napier, J. A. and Stobart, A. K. 1998. Isolation of a Delta(5)-fatty acid desaturase gene from Mortierella alpina. Journal of Biological Chemistry. 273 (30), pp. 19055-19059. https://doi.org/10.1074/jbc.273.30.19055
Identification of a Caenorhabditis elegans Delta(6)-fatty-acid-desaturase by heterologous expression in Saccharomyces cerevisiae
A - Papers appearing in refereed journals
Napier, J. A., Hey, S. J., Lacey, D. J. and Shewry, P. R. 1998. Identification of a Caenorhabditis elegans Delta(6)-fatty-acid-desaturase by heterologous expression in Saccharomyces cerevisiae. Biochemical Journal. 330 (2), pp. 611-614. https://doi.org/10.1042/bj3300611
Functional identification of a fatty acid Delta 5 desaturase gene from Caenorhabditis elegans
A - Papers appearing in refereed journals
Michaelson, L. V., Napier, J. A., Lewis, M., Griffiths, G., Lazarus, C. M. and Stobart, A. K. 1998. Functional identification of a fatty acid Delta 5 desaturase gene from Caenorhabditis elegans. FEBS Letters. 439 (3), pp. 215-218. https://doi.org/10.1016/s0014-5793(98)01385-4
Expression of a borage desaturase cDNA containing an N-terminal cytochrome b(5) domain results in the accumulation of high levels of Delta(6)-desaturated fatty acids in transgenic tobacco
A - Papers appearing in refereed journals
Sayanova, O. V., Smith, M. A., Lapinskas, P., Stobart, A. K., Dobson, G., Christie, W. W., Shewry, P. R. and Napier, J. A. 1997. Expression of a borage desaturase cDNA containing an N-terminal cytochrome b(5) domain results in the accumulation of high levels of Delta(6)-desaturated fatty acids in transgenic tobacco. Proceedings of the National Academy of Sciences. 94 (8), pp. 4211-4216. https://doi.org/10.1073/pnas.94.8.4211
Trafficking of wheat gluten proteins in transgenic tobacco plants: gamma-gliadin does not contain an endoplasmic reticulum retention signal
A - Papers appearing in refereed journals
Napier, J. A., Richard, G., Turner, M. F. P. and Shewry, P. R. 1997. Trafficking of wheat gluten proteins in transgenic tobacco plants: gamma-gliadin does not contain an endoplasmic reticulum retention signal. Planta. 203 (4), pp. 488-494. https://doi.org/10.1007/s004250050218
Tobacco rab1 cDNA cloning and expression and structure-functional analysis of the Rab1 protein
A - Papers appearing in refereed journals
Andreeva, A. V., Evans, D. E., Hawes, C. R. and Napier, J. A. 1997. Tobacco rab1 cDNA cloning and expression and structure-functional analysis of the Rab1 protein. Russian Journal Of Bioorganic Chemistry. 23 (3), pp. 183-190.
Chloroplast SecA functions as a membrane-associated component of the Sec-like protein translocase of pea chloroplasts
A - Papers appearing in refereed journals
Haward, S. R., Napier, J. A. and Gray, J. C. 1997. Chloroplast SecA functions as a membrane-associated component of the Sec-like protein translocase of pea chloroplasts. European Journal of Biochemistry. 248 (3), pp. 724-730. https://doi.org/10.1111/j.1432-1033.1997.00724.x
A new class of cytochrome b(5) fusion proteins
A - Papers appearing in refereed journals
Napier, J. A., Sayanova, O. V., Stobart, A. K. and Shewry, P. R. 1997. A new class of cytochrome b(5) fusion proteins. Biochemical Journal. 328 (2), pp. 717-720. https://doi.org/10.1042/bj3280717u
Transport and deposition of cereal prolamins
A - Papers appearing in refereed journals
Richard, G., Turner, M. P. F., Napier, J. A. and Shewry, P. R. 1996. Transport and deposition of cereal prolamins. Plant Physiology and Biochemistry. 34 (2), pp. 237-243.
The structure and biogenesis of plant oil bodies: The role of the ER membrane and the oleosin class of proteins
A - Papers appearing in refereed journals
Napier, J. A., Stobart, A. K. and Shewry, P. R. 1996. The structure and biogenesis of plant oil bodies: The role of the ER membrane and the oleosin class of proteins. Plant Molecular Biology. 31 (5), pp. 945-956. https://doi.org/10.1007/bf00040714
Comparison of the expression patterns of genes coding for wheat gluten proteins and proteins involved in the secretory pathway in developing caryopses of wheat
A - Papers appearing in refereed journals
Grimwade, B., Tatham, A. S., Freedman, R. B., Shewry, P. R. and Napier, J. A. 1996. Comparison of the expression patterns of genes coding for wheat gluten proteins and proteins involved in the secretory pathway in developing caryopses of wheat. Plant Molecular Biology. 30 (5), pp. 1067-1073. https://doi.org/10.1007/bf00020817
Characterization of a sunflower seed albumin which associates with oil bodies
A - Papers appearing in refereed journals
Thoyts, P. J. E., Napier, J. A., Millichip, M., Stobart, A. K., Griffiths, W. T., Tatham, A. S. and Shewry, P. R. 1996. Characterization of a sunflower seed albumin which associates with oil bodies. Plant Science. 118 (2), pp. 119-125. https://doi.org/10.1016/0168-9452(96)04429-9
The use of biotechnology to develop new crops and modify the properties of traditional crops
C1 - Edited contributions to conferences/learned societies
Shewry, P. R., Napier, J. A., Cooke, D. T. and Lazzeri, P. A. 1996. The use of biotechnology to develop new crops and modify the properties of traditional crops. Proceedings Society for Economic Botany Conference on Domestication, Production and Utilization of New Crops, Southampton, 7-12 July 1996 .
Seed storage proteins: structures and biosynthesis
A - Papers appearing in refereed journals
Shewry, P. R., Napier, J. A. and Tatham, A. S. 1995. Seed storage proteins: structures and biosynthesis. The Plant Cell. 7 (7), pp. 945-956. https://doi.org/10.1105/tpc.7.7.945
Isolation of a cDNA encoding a cytochrome b5 specifically expressed in developing tobacco seeds
A - Papers appearing in refereed journals
Napier, J. A., Smith, M. A., Stobart, A. K. and Shewry, P. R. 1995. Isolation of a cDNA encoding a cytochrome b5 specifically expressed in developing tobacco seeds. Planta. 197 (1), pp. 200-202. https://doi.org/10.1007/BF00239957
Isolation and characterisation of cDNA clones representing the genes encoding the major tuber storage protein (dioscorin) of yam (Dioscorea cayenensis Lam.)
A - Papers appearing in refereed journals
Conlan, R. S., Griffiths, L. A., Napier, J. A., Shewry, P. R., Mantell, S. and Ainsworth, C. 1995. Isolation and characterisation of cDNA clones representing the genes encoding the major tuber storage protein (dioscorin) of yam (Dioscorea cayenensis Lam.). Plant Molecular Biology. 28 (3), pp. 369-380. https://doi.org/10.1007/bf00020387
Expression and in vitro targeting of a sunflower oleosin
A - Papers appearing in refereed journals
Thoyts, P. J. E., Millichip, M. I., Stobart, A. K., Griffiths, W. T., Shewry, P. R. and Napier, J. A. 1995. Expression and in vitro targeting of a sunflower oleosin. Plant Molecular Biology. 29 (2), pp. 403-410. https://doi.org/10.1007/bf00043664
Tobacco cytochromeb5: cDNA isolation, expression analysis and in vitro protein targeting
A - Papers appearing in refereed journals
Smith, M. A., Stobart, A. K., Shewry, P. R. and Napier, J. A. 1994. Tobacco cytochromeb5: cDNA isolation, expression analysis and in vitro protein targeting. Plant Molecular Biology. 25 (3), pp. 527-537. https://doi.org/10.1007/bf00043880
Expression of a biologically active plant cytochrome b5 in Escherichia coli
A - Papers appearing in refereed journals
Smith, M. A., Napier, J. A., Stymne, S., Tatham, A. S., Shewry, P. R. and Stobart, A. K. 1994. Expression of a biologically active plant cytochrome b5 in Escherichia coli. Biochemical Journal. 303, pp. 73-79.
Newly imported rieske iron-sulfur protein associates with both Cpn60 and Hsp70 in the chloroplast stroma
A - Papers appearing in refereed journals
Madueno, F., Napier, J. A. and Gray, J. C. 1993. Newly imported rieske iron-sulfur protein associates with both Cpn60 and Hsp70 in the chloroplast stroma. The Plant Cell. 5 (12), pp. 1865-1876. https://doi.org/10.1105/tpc.5.12.1865
Import of the precursor of the chloroplast Rieske iron-sulphur protein by pea chloroplasts
A - Papers appearing in refereed journals
Salter, A. H., Newman, B. J., Napier, J. A. and Gray, J. C. 1992. Import of the precursor of the chloroplast Rieske iron-sulphur protein by pea chloroplasts. Plant Molecular Biology. 20 (3), pp. 569-574. https://doi.org/10.1007/bf00040617
Import and processing of the precursor of the Rieske FeS protein of tobacco chloroplasts
A - Papers appearing in refereed journals
Madueno, F., Napier, J. A., Cejudo, F. J. and Gray, J. C. 1992. Import and processing of the precursor of the Rieske FeS protein of tobacco chloroplasts. Plant Molecular Biology. 20 (2), pp. 289-299. https://doi.org/10.1007/bf00014496
Import and processing of the precursor of the delta subunit of tobacco chloroplast ATP synthase
A - Papers appearing in refereed journals
Napier, J. A., Larsson, K. H., Madueno, F. and Gray, J. C. 1992. Import and processing of the precursor of the delta subunit of tobacco chloroplast ATP synthase. Plant Molecular Biology. 20 (3), pp. 549-554. https://doi.org/10.1007/bf00040613
Import and processing of the precursor form of the gamma subunit of the chloroplast ATP synthase from tobacco
A - Papers appearing in refereed journals
Larsson, K. H., Napier, J. A. and Gray, J. C. 1992. Import and processing of the precursor form of the gamma subunit of the chloroplast ATP synthase from tobacco. Plant Molecular Biology. 19 (2), pp. 343-349. https://doi.org/10.1007/bf00027359
Chloroplast import of the precursor of the gamma subunit of pea chloroplast ATP synthase
A - Papers appearing in refereed journals
Napier, J. A., Hoglund, A. S., Plant, A. L. and Gray, J. C. 1992. Chloroplast import of the precursor of the gamma subunit of pea chloroplast ATP synthase. Plant Molecular Biology. 20 (4), pp. 737-741. https://doi.org/10.1007/bf00046458
Calcium-dependent induction of novel proteins by abscisic acid in wheat aleurone tissue of different developmental stages
A - Papers appearing in refereed journals
Napier, J. A., Chapman, J. M. and Black, M. 1989. Calcium-dependent induction of novel proteins by abscisic acid in wheat aleurone tissue of different developmental stages. Planta. 179 (2), pp. 156-164. https://doi.org/10.1007/bf00393685
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