A - Papers appearing in refereed journals
Gaines, T. A., Patterson, E. L. and Neve, P. 2019. Molecular mechanisms of adaptive evolution revealed by global selection for glyphosate resistance [Tansley insight]. New Phytologist. 223 (4), pp. 1770-1775.
|Authors||Gaines, T. A., Patterson, E. L. and Neve, P.|
The human‐directed, global selection for glyphosate resistance in weeds has revealed a fascinating diversity of evolved resistance mechanisms, including herbicide sequestration in the vacuole, a rapid cell death response, nucleotide polymorphisms in the herbicide target (5‐enolpyruvylshikimate‐3‐phosphate synthase, EPSPS) and increased gene copy number of EPSPS. For this latter mechanism, two distinct molecular genetic mechanisms have been observed, a tandem duplication mechanism and a large extrachromosomal circular DNA (eccDNA) that is tethered to the chromosomes and passed to gametes at meiosis. These divergent mechanisms have a range of consequences for the spread, fitness, and inheritance of resistance traits, and, particularly in the case of the eccDNA, demonstrate how evolved herbicide resistance can generate new insights into plant adaptation to contemporary environmental stress.
|Year of Publication||2019|
|Journal citation||223 (4), pp. 1770-1775|
|Digital Object Identifier (DOI)||doi:10.1111/nph.15858|
|Open access||Published as bronze (free) open access|
|Funder||Biotechnology and Biological Sciences Research Council|
|Funder project or code||United States: Harnessing next-generation sequencing technologies for eco-evolutionary studies of herbicide resistance and weed biology|
File Access Level
|Online||19 Apr 2019|
|Publication process dates|
|Accepted||09 Apr 2019|
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