Miyabeacin: A new cyclodimer presents a potential role for willow in cancer therapy.

A - Papers appearing in refereed journals

Ward, J. L., Wu, Y., Harflett, C., Onafuye, H., Corol, D. I., Lomax, C., Macalpine, W. J., Cinatl, J., Wass, M. N., Michaelis, M. and Beale, M. H. 2020. Miyabeacin: A new cyclodimer presents a potential role for willow in cancer therapy. Scientific Reports. 10, p. 6477.

AuthorsWard, J. L., Wu, Y., Harflett, C., Onafuye, H., Corol, D. I., Lomax, C., Macalpine, W. J., Cinatl, J., Wass, M. N., Michaelis, M. and Beale, M. H.
Abstract

Willow (Salix spp.) is well known as a source of medicinal compounds, the most famous being salicin, the progenitor of aspirin. Here we describe the isolation, structure determination, and anti-cancer activity of a cyclodimeric salicinoid (miyabeacin) from S. miyabeana and S. dasyclados. We also show that the capability to produce such dimers is a heritable trait and how variation in structures of natural miyabeacin analogues is derived via cross-over Diels-Alder reactions from pools of ortho-quinol precursors. These transient ortho-quinols have a role in the, as yet uncharacterised, biosynthetic pathways around salicortin, the major salicinoid of many willow genotypes.

KeywordsWillow; Miyabeacin; Metabolomics; Cancer; Salix; NMR; Mass Spectrometry
Year of Publication2020
JournalScientific Reports
Journal citation10, p. 6477
Digital Object Identifier (DOI)doi:10.1038/s41598-020-63349-1
Open accessPublished as ‘gold’ (paid) open access
FunderEngineering and Physical Sciences Research Council
Biotechnology and Biological Sciences Research Council
Funder project or codeTPM - Tailoring Plant Metabolism - Work package 2 (WP2) - Designer Willows: high value phenolic glycosides for health and industry
Maximising carbon harvest from perennial crops
Ionic Liquid Biorefining of Lignocellulose to Sustainable Polymers
Publisher's version
Accepted author manuscript
Supplemental file
Output statusPublished
Publication dates
Online15 Apr 2020
Publication process dates
Accepted27 Mar 2020
PublisherNature Publishing Group
ISSN2045-2322

Permalink - https://repository.rothamsted.ac.uk/item/97670/miyabeacin-a-new-cyclodimer-presents-a-potential-role-for-willow-in-cancer-therapy

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