The genetic architecture of a host shift: An adaptive walk protected an aphid and its endosymbiont from plant chemical defenses

A - Papers appearing in refereed journals

Singh, K. S., Troczka, B. J., Duarte, A., Balabanidou, V., Trissi, N., Paladino, L. Z. C., Nguyen, P., Zimmer, C. T., Papapostolou, K. M., Randall, E., Lueke, B., Marec, F., Mazzoni, E., Williamson, M. S., Hayward, A., Nauen, R., Vontas, J. and Bass, C. G. 2020. The genetic architecture of a host shift: An adaptive walk protected an aphid and its endosymbiont from plant chemical defenses. Science Advances. 6 (19), p. eaba1070.

AuthorsSingh, K. S., Troczka, B. J., Duarte, A., Balabanidou, V., Trissi, N., Paladino, L. Z. C., Nguyen, P., Zimmer, C. T., Papapostolou, K. M., Randall, E., Lueke, B., Marec, F., Mazzoni, E., Williamson, M. S., Hayward, A., Nauen, R., Vontas, J. and Bass, C. G.
Abstract

Host shifts can lead to ecological speciation and the emergence of new pests and pathogens. However, the mutational events that facilitate the exploitation of novel hosts are poorly understood. Here, we characterize an adaptive walk underpinning the host shift of the aphid Myzus persicae to tobacco, including evolution of mechanisms that overcame tobacco chemical defenses. A series of mutational events added as many as 1.5 million nucleotides to the genome of the tobacco-adapted subspecies, M. p. nicotianae, and yielded profound increases in expression of an enzyme that efficiently detoxifies nicotine, both in aphid gut tissue and in the bacteriocytes housing the obligate aphid symbiont Buchnera aphidicola. This dual evolutionary solution overcame the challenge of preserving fitness of a mutualistic symbiosis during adaptation to a toxic novel host. Our results reveal the intricate processes by which genetic novelty can arise and drive the evolution of key innovations required for ecological adaptation.

KeywordsMyzus persicae; Insecticide resistance; Chromosomal rearrangement
Year of Publication2020
JournalScience Advances
Journal citation6 (19), p. eaba1070
Digital Object Identifier (DOI)doi:10.1126/sciadv.aba1070
PubMed ID32494722
PubMed Central ID7202869
Web address (URL)https://advances.sciencemag.org/content/6/19/eaba1070/tab-pdf
Open accessPublished as ‘gold’ (paid) open access
FunderEuropean Research Council
Biotechnology and Biological Sciences Research Council
Funder project or codeBB/N020146/1
Publisher's version
Output statusPublished
Publication dates
Online06 May 2020
Publication process dates
Accepted18 Feb 2020
PublisherAmerican Association for the Advancement of Science (AAAS)
ISSN2375-2548

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