Defning lipids and T cell receptors involved in the intrinsic allergenicity of nut proteins

Wang, R., Ghumra, A., Cochrane, S., Fairclough, L., Broughton, R., Michaelson, L. V., Beaudoin, F. and Alcocer, M. J. C. 2020. Defning lipids and T cell receptors involved in the intrinsic allergenicity of nut proteins. Clinical and Translational Allergy. 10, p. 54. https://doi.org/10.1186/s13601-020-00358-3

Authors	Wang, R., Ghumra, A., Cochrane, S., Fairclough, L., Broughton, R., Michaelson, L. V., Beaudoin, F. and Alcocer, M. J. C.
Year of Publication	2020
Journal	Clinical and Translational Allergy
Journal citation	10, p. 54
Digital Object Identifier (DOI)	https://doi.org/10.1186/s13601-020-00358-3
Open access	Published as ‘gold’ (paid) open access
Funder	Biotechnology and Biological Sciences Research Council
Funder project or code	Tailoring Plant Metabolism (TPM) - Work package 1 (WP1) - High value lipids for health and industry
Publisher's version	Wang et al 2020 Clin Transl Allergy.pdf
Output status	Published
Publication dates
Online	25 Nov 2020
Publication process dates
Accepted	03 Nov 2020
Publisher	Springer Nature
ISSN	2045-7022

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Characterization of a glutenin-specific serine proteinase of Sunn bug Eurygaster integricepts Put.

A - Papers appearing in refereed journals

Konarev, A. V., Beaudoin, F., Marsh, J., Vilkova, N. A., Nefedova, L. I., Sivri, D., Koksel, H., Shewry, P. R. and Lovegrove, A. 2011. Characterization of a glutenin-specific serine proteinase of Sunn bug Eurygaster integricepts Put. Journal of Agricultural and Food Chemistry - JAFC. 59, pp. 2462-2470. https://doi.org/10.1021/jf103867g

Identification and characterization of novel natural alleles of eIF4E in barley providing broad-spectrum resistance to bymoviruses

C2 - Non-edited contributions to conferences

Hofinger, B. J., Bass, C., Baldwin, T., Jing, H-C., Beaudoin, F., Hammond-Kosack, K. E. and Kanyuka, K. 2010. Identification and characterization of novel natural alleles of eIF4E in barley providing broad-spectrum resistance to bymoviruses. Antoun, H., Trepanier, M., Prevost, D., Brisson, L. and Avis, T. (ed.) Biology of plant-microbe interactions, vol. 7 . International Society for Molecular Plant-Microbe Interactions, St. Paul. pp. Paper 71

Viral trans- dominant manipulation of algal sphingolipids

A - Papers appearing in refereed journals

Michaelson, L. V., Dunn, T. M. and Napier, J. A. 2010. Viral trans- dominant manipulation of algal sphingolipids. Trends in Plant Science. 15, pp. 651-655. https://doi.org/10.1016/j.tplants.2010.09.004

The sunflower plastidial omega3-fatty acid desaturase (Ha FAD7) contains the signalling determinants required for targeting to, and retention in, the endoplasmic reticulum membrane in yeast but requires co-expressed ferredoxin for activity

A - Papers appearing in refereed journals

Venegas-Caleron, M., Beaudoin, F., Garces, R., Napier, J. A. and Martinez-Force, E. 2010. The sunflower plastidial omega3-fatty acid desaturase (Ha FAD7) contains the signalling determinants required for targeting to, and retention in, the endoplasmic reticulum membrane in yeast but requires co-expressed ferredoxin for activity. Phytochemistry. 71, pp. 1050-1058. https://doi.org/10.1016/j.phytochem.2010.04.017

Very-long-chain fatty acids are involved in polar auxin transport and developmental patterning in Arabidopsis

A - Papers appearing in refereed journals

Roudier, F., Gissot, L., Beaudoin, F., Haslam, R. P., Michaelson, L. V., Marion, J., Molino, D., Lima, A., Bach, L., Morin, H., Tellier, F., Palauqui, J-C., Bellec, Y., Renne, C., Miquel, M., Dacosta, M., Vignard, J., Rochat, C., Markham, J. E., Moreau, P., Napier, J. A. and Faure, J-D. 2010. Very-long-chain fatty acids are involved in polar auxin transport and developmental patterning in Arabidopsis. The Plant Cell. 22, pp. 364-375. https://doi.org/10.1105/tpc.109.071209

Sphingolipid signaling in plants

B - Book chapters etc edited externally

Michaelson, L. V. and Napier, J. A. 2010. Sphingolipid signaling in plants. in: Munnik, T. (ed.) Lipid signaling in plants (Plant Cell Monographs, 16) Springer, Berlin. pp. 307-321

Misexpression of FATTY ACID ELONGATION1 in the Arabidopsis Epidermis Induces Cell Death and Suggests a Critical Role for Phospholipase A2 in This Process

A - Papers appearing in refereed journals

Reina-Pinto, J. J., Voisin, D., Kurdyukov, S., Faust, A., Haslam, R. P., Michaelson, L. V., Efremova, N., Franke, B., Schreiber, L., Napier, J. A. and Yephremov, A. 2009. Misexpression of FATTY ACID ELONGATION1 in the Arabidopsis Epidermis Induces Cell Death and Suggests a Critical Role for Phospholipase A2 in This Process. The Plant Cell. 21 (4), pp. 1252-1272. https://doi.org/10.1105/tpc.109.065565

Exploiting natural genetic diversity of barley germplasm to identify superior alleles of eIF4E conferring broad-spectrum virus resistance

C2 - Non-edited contributions to conferences

Hofinger, B. J., Bass, C., Baldwin, T., Beaudoin, F., Hammond-Kosack, K. E. and Kanyuka, K. 2009. Exploiting natural genetic diversity of barley germplasm to identify superior alleles of eIF4E conferring broad-spectrum virus resistance. Abstracts Rank Prize Funds Mini-Symposium on Domestication of Cereals and Exploitation of Genetic Diversity in Improvement, Grasmere, 21-24 September 2009 .

A new rapid and relatively inexpensive method for mining in plant germplasm collections for novel alleles of agronomically important genes: a case study in barley

C2 - Non-edited contributions to conferences

Hofinger, B. J., Bass, C., Baldwin, T., Jing, H-C., Beaudoin, F., Hammond-Kosack, K. E. and Kanyuka, K. 2009. A new rapid and relatively inexpensive method for mining in plant germplasm collections for novel alleles of agronomically important genes: a case study in barley. Abstracts 19th ITMI/3rd COST Tritigen Joint Workshop, Clermont-Ferrand, 31 August-4 September 2009 . pp. 34

Identification and characterization of novel natural alleles of eIF4E in barley providing broad-spectrum resistance to Bymoviruses

C2 - Non-edited contributions to conferences

Hofinger, B. J., Bass, C., Baldwin, T., Jing, H-C., Beaudoin, F., Hammond-Kosack, K. E. and Kanyuka, K. 2009. Identification and characterization of novel natural alleles of eIF4E in barley providing broad-spectrum resistance to Bymoviruses. Abstracts 14th International Congress on Molecular Plant-Microbe Interactions, Quebec, 19-23 July 2009 . pp. 18

Exploiting the genetic diversity of natural barley germplasm for the discovery of novel eIF4E alleles conferring broad spectrum resistance to bymoviruses

C2 - Non-edited contributions to conferences

Hofinger, B. J., Bass, C., Baldwin, T., Beaudoin, F., Hammond-Kosack, K. E. and Kanyuka, K. 2009. Exploiting the genetic diversity of natural barley germplasm for the discovery of novel eIF4E alleles conferring broad spectrum resistance to bymoviruses. Abstracts International Conference on Advances in Plant Virology, Harrogate, 1-3 April 2009 .

Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase

A - Papers appearing in refereed journals

Beaudoin, F., Wu, X., Li, F., Haslam, R. P., Markham, J. E., Zheng, H., Napier, J. A. and Kunst, L. 2009. Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase. Plant Physiology. 150, pp. 1174-1191. https://doi.org/10.1104/pp.109.137497

Functional characterization of a higher plant sphingolipid delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis

A - Papers appearing in refereed journals

Michaelson, L. V., Zauner, S., Markham, J. E., Haslam, R. P., Desikan, R., Mugford, S., Albrecht, S., Warnecke, D., Sperling, P., Heinz, E. and Napier, J. A. 2009. Functional characterization of a higher plant sphingolipid delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis. Plant Physiology. 149, pp. 487-498. https://doi.org/10.1104/pp.108.129411

The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development

A - Papers appearing in refereed journals

Bach, L., Michaelson, L. V., Haslam, R. P., Bellec, Y., Gissot, L., Marion, J., Da Costa, M., Boutin, J-P., Miquel, M., Tellier, F., Domergue, F., Markham, J. E., Beaudoin, F., Napier, J. A. and Faure, J-D. 2008. The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development. Proceedings of the National Academy of Sciences. 105, pp. 14727-14731. https://doi.org/10.1073/pnas.0805089105

Discovery of novel e1F4 alleles conferring broad spectrum resistance to bymoviruses by exploiting genetic diversity of natural barley germplasm

C2 - Non-edited contributions to conferences

Hofinger, B. J., Bass, C. G., Baldwin, T., Beaudoin, F., Hammond-Kosack, K. E. and Kanyuka, K. 2008. Discovery of novel e1F4 alleles conferring broad spectrum resistance to bymoviruses by exploiting genetic diversity of natural barley germplasm. Abstracts 7th Symposium of the International Working Group on Plant Viruses with Fungal Vectors, Quedlinburg, 31 August - 4 September 2008 . pp. 29

Properties and exploitation of oleosins

A - Papers appearing in refereed journals

Capuano, F., Beaudoin, F., Napier, J. A. and Shewry, P. R. 2007. Properties and exploitation of oleosins. Biotechnology Advances. 25, pp. 203-206. https://doi.org/10.1016/j.biotechadv.2006.11.006

Characterization of lipid rafts from Medicago truncatula root plasma membranes: a proteomic study reveals the presence of a raft-associated redox system

A - Papers appearing in refereed journals

Lefebvre, B., Furt, F., Hartmann, M-A., Michaelson, L. V., Carde, J-P., Sargueil-Boiron, F., Rossignol, M., Napier, J. A., Cullimore, J., Bessoule, J-J. and Mongrand, S. 2007. Characterization of lipid rafts from Medicago truncatula root plasma membranes: a proteomic study reveals the presence of a raft-associated redox system. Plant Physiology. 144, pp. 402-418. https://doi.org/10.1104/pp.106.094102

Cloning and molecular characterisation of a delta8- sphingolipid-desaturase from Nicotiana tabacum closely related to delta6-acyl-desaturases

A - Papers appearing in refereed journals

Garcia-Maroto, F., Garrido-Cardenas, J. A., Michaelson, L. V., Napier, J. A. and Alonso, D. L. 2007. Cloning and molecular characterisation of a delta8- sphingolipid-desaturase from Nicotiana tabacum closely related to delta6-acyl-desaturases. Plant Molecular Biology. 64, pp. 241-250. https://doi.org/10.1007/s11103-007-9148-9

Co-transcribed genes for long chain polyunsaturated fatty acid biosynthesis in the protozoon Perkinsus marinus include a plant-like FAE1 3-ketoacyl coenzyme A synthase

A - Papers appearing in refereed journals

Venegas-Caleron, M., Beaudoin, F., Sayanova, O. V. and Napier, J. A. 2007. Co-transcribed genes for long chain polyunsaturated fatty acid biosynthesis in the protozoon Perkinsus marinus include a plant-like FAE1 3-ketoacyl coenzyme A synthase. Journal of Biological Chemistry. 282, pp. 2996-3003. https://doi.org/10.1074/jbc.M607051200

Transcriptome analysis reveals differentially expressed storage protein transcripts in seeds of Aegilops and wheat

A - Papers appearing in refereed journals

Kan, Y., Wan, Y., Beaudoin, F., Leader, D. J., Edwards, K., Poole, R., Wang, D., Mitchell, R. A. C. and Shewry, P. R. 2006. Transcriptome analysis reveals differentially expressed storage protein transcripts in seeds of Aegilops and wheat. Journal of Cereal Science. 44, pp. 75-85. https://doi.org/10.1016/j.jcs.2006.04.004

Members of the Arabidopsis FAE1-like 3-ketoacyl-CoA synthase gene family substitute for the Elop proteins of Saccharomyces cerevisiae

A - Papers appearing in refereed journals

Paul, S., Gable, K., Beaudoin, F., Cahoon, E., Jaworski, J., Napier, J. A. and Dunn, T. M. 2006. Members of the Arabidopsis FAE1-like 3-ketoacyl-CoA synthase gene family substitute for the Elop proteins of Saccharomyces cerevisiae. Journal of Biological Chemistry. 281, pp. 9018-9029. https://doi.org/10.1074/jbc.M507723200

Progress towards the production of very long-chain polyunsaturated fatty acid in transgenic plants: plant metabolic engineering comes of age

A - Papers appearing in refereed journals

Napier, J. A., Haslam, R. P., Venegas Caleron, M., Michaelson, L. V., Beaudoin, F. and Sayanova, O. V. 2006. Progress towards the production of very long-chain polyunsaturated fatty acid in transgenic plants: plant metabolic engineering comes of age. Physiologia Plantarum. 126 (3), pp. 398-406. https://doi.org/10.1111/j.1399-3054.2005.00603.x

Plant protein families as a basis for predicting the allergenicity of food proteins

B - Book chapters etc edited externally

Shewry, P. R., Jenkins, J., Beaudoin, F. and Mills, E. N. C. 2006. Plant protein families as a basis for predicting the allergenicity of food proteins. in: Wichers, H. J., Bogers, R. J., Savelkoul, H. F. J. and Gilissen, L. J. W. J. (ed.) Allergy matters: new approaches to allergy prevention and management Springer, Dordrecht. pp. 41-46

Overview and analysis of the polyprotein cleavage sites in the family Potyviridae

A - Papers appearing in refereed journals

Adams, M. J., Antoniw, J. F. and Beaudoin, F. 2005. Overview and analysis of the polyprotein cleavage sites in the family Potyviridae. Molecular Plant Pathology. 6 (4), pp. 471-487. https://doi.org/10.1111/J.1364-3703.2005.00296.X

Fatty acid desaturases from the microalga Thalassiosira pseudonana

A - Papers appearing in refereed journals

Tonon, T., Sayanova, O. V., Michaelson, L. V., Qing, R., Harvey, D., Larson, T. R., Li, Y., Napier, J. A. and Graham, I. A. 2005. Fatty acid desaturases from the microalga Thalassiosira pseudonana. The FEBS Journal. 272 (13), pp. 3401-3412. https://doi.org/10.1111/j.1742-4658.2005.04755.x

Plant FAE1-like condensing enzymes substiute for the Elop proteins in Saccharomyces cerevisiae

C2 - Non-edited contributions to conferences

Paul, S., Gable, K., Beaudoin, F., Napier, J. A. and Dunn, T. M. 2005. Plant FAE1-like condensing enzymes substiute for the Elop proteins in Saccharomyces cerevisiae.

Reverse engineering of long-chain polyunsaturated fatty acid biosynthesis into transgenic plants

A - Papers appearing in refereed journals

Napier, J. A., Beaudoin, F. and Sayanova, O. V. 2005. Reverse engineering of long-chain polyunsaturated fatty acid biosynthesis into transgenic plants. European Journal Of Lipid Science And Technology. 107 (4), pp. 249-255. https://doi.org/10.1002/ejlt.200590022

Design, expression and characterisation of lysine-rich forms of the barley seed protein CI-2

A - Papers appearing in refereed journals

Forsyth, J. L., Beaudoin, F., Halford, N. G., Sessions, R. B., Clarke, A. R. and Shewry, P. R. 2005. Design, expression and characterisation of lysine-rich forms of the barley seed protein CI-2. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1747, pp. 221-227. https://doi.org/10.1016/j.bbapap.2004.11.018

Analysis of detergent-resistant membranes in Arabidopsis. Evidence for plasma membrane lipid rafts

A - Papers appearing in refereed journals

Borner, G. H. H., Sherrier, D. J., Weimar, T., Michaelson, L. V., Hawkins, N. D., Macaskill, A., Napier, J. A., Beale, M. H., Lilley, K. S. and Dupree, P. 2005. Analysis of detergent-resistant membranes in Arabidopsis. Evidence for plasma membrane lipid rafts. Plant Physiology. 137 (1), pp. 104-116. https://doi.org/10.1104/pp.104.053041

The production of long chain polyunsaturated fatty acids in transgenic plants

B - Book chapters etc edited externally

Napier, J. A., Beaudoin, F., Michaelson, L. V. and Sayanova, O. V. 2004. The production of long chain polyunsaturated fatty acids in transgenic plants. in: Setlow, J. K. (ed.) Genetic engineering: principles and methods. Vol. 26 Springer, New York. pp. 143-157

Biosynthesis and compartmentation of triacylglycerol in higher plants

B - Book chapters etc edited externally

Beaudoin, F. and Napier, J. A. 2004. Biosynthesis and compartmentation of triacylglycerol in higher plants. in: Daum, G. (ed.) Lipid metabolism and membrane biogenesis Springer, New York. pp. 267-287

The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering

A - Papers appearing in refereed journals

Napier, J. A., Beaudoin, F., Michaelson, L. V. and Sayanova, O. V. 2004. The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering. Biochimie. 86, pp. 785-793.

A post-genomic approach to understanding sphingolipid metabolism in Arabidopsis thaliana

A - Papers appearing in refereed journals

Dunn, T. M., Lynch, D. V., Michaelson, L. V. and Napier, J. A. 2004. A post-genomic approach to understanding sphingolipid metabolism in Arabidopsis thaliana. Annals of Botany. 93, pp. 483-497.

SNF1-related protein kinase (SnRK1) phosphorylates class I heat shock protein

A - Papers appearing in refereed journals

Slocombe, S. P., Beaudoin, F., Donaghy, P. G., Hardie, D. G., Dickinson, J. R. and Halford, N. G. 2004. SNF1-related protein kinase (SnRK1) phosphorylates class I heat shock protein. Plant Physiology and Biochemistry. 42, pp. 111-116.

The classification, functions and evolutionary relationships of plant proteins in relation to food allergies

B - Book chapters etc edited externally

Jenkins, J. A. and Beaudoin, F. 2004. The classification, functions and evolutionary relationships of plant proteins in relation to food allergies. in: Shewry, P. R. and Mills, E. N. C. (ed.) Plant food allergens Blackwell Scientific Publications, Oxford. pp. 24-41

Desaturase (Patent US 2003/0152983 A1)

H2 - Patents applied for

Napier, J. A., Michaelson, L. V. and Stobart, K. 2003. Desaturase (Patent US 2003/0152983 A1). US 2003/0152983 A1

Identification of Primula fatty acid delta6-desaturases with n-3 substrate preferences

A - Papers appearing in refereed journals

Sayanova, O. V., Beaudoin, F., Michaelson, L. V., Shewry, P. R. and Napier, J. A. 2003. Identification of Primula fatty acid delta6-desaturases with n-3 substrate preferences. FEBS Letters. 542 (1-3), pp. 100-104. https://doi.org/10.1016/S0014-5793(03)00358-2

The role of cytochrome b 5 fusion desaturases in the synthesis of polyunsaturated fatty acids

A - Papers appearing in refereed journals

Napier, J. A., Michaelson, L. V. and Sayanova, O. V. 2003. The role of cytochrome b 5 fusion desaturases in the synthesis of polyunsaturated fatty acids. Prostaglandins, Leukotrienes and Essential Fatty Acids. 68 (2), pp. 135-143. https://doi.org/10.1016/S0952-3278(02)00263-6

The dihydroceramide desaturase is not essential for cell viability in Schizosaccharomyces pombe

A - Papers appearing in refereed journals

Garton, S., Michaelson, L. V., Beaudoin, F., Beale, M. H. and Napier, J. A. 2003. The dihydroceramide desaturase is not essential for cell viability in Schizosaccharomyces pombe. FEBS Letters. 538, pp. 192-196.

New lipid-derived signals in plants and their role in modulating gene expression

C2 - Non-edited contributions to conferences

Matthes, M. C., Michaelson, L. V., Beaudoin, F., Garton, S., Pickett, J. A. and Napier, J. A. 2003. New lipid-derived signals in plants and their role in modulating gene expression.

Functional characterisation of two cytochrome b 5-fusion desaturases from Anemone leveillei : the unexpected identification of a fatty acid delta6-desaturase

A - Papers appearing in refereed journals

Whitney, H. M., Michaelson, L. V., Sayanova, O. V., Pickett, J. A. and Napier, J. A. 2003. Functional characterisation of two cytochrome b 5-fusion desaturases from Anemone leveillei : the unexpected identification of a fatty acid delta6-desaturase. Planta. 217 (6), pp. 983-992. https://doi.org/10.1007/s00425-003-1069-5

Identification of a cDNA encoding a novel C18-delta9 polyunsaturated fatty acid-specific elongating activity from the docosahexaenoic acid (DHA)-producing microalga, Isochrysis galbana

A - Papers appearing in refereed journals

Qi, B., Beaudoin, F., Fraser, T., Stobart, A. K., Napier, J. A. and Lazarus, C. M. 2002. Identification of a cDNA encoding a novel C18-delta9 polyunsaturated fatty acid-specific elongating activity from the docosahexaenoic acid (DHA)-producing microalga, Isochrysis galbana. FEBS Letters. 510 (3), pp. 159-165. https://doi.org/10.1016/S0014-5793(01)03247-1

A new class of lipid desaturase central to sphingolipid biosynthesis and signalling

A - Papers appearing in refereed journals

Napier, J. A., Michaelson, L. V. and Dunn, T. M. 2002. A new class of lipid desaturase central to sphingolipid biosynthesis and signalling. Trends in Plant Science. 7, pp. 475-478.

Altering specifity of a Ricinus communis cytochrome b5 fusion desaturase

A - Papers appearing in refereed journals

Michaelson, L. V. and Napier, J. A. 2002. Altering specifity of a Ricinus communis cytochrome b5 fusion desaturase. Biochemical Society Transactions. 30 (5), p. A123. https://doi.org/10.1042/bst030a123a

Isolation and characterization of a cDNA encoding a delta8 sphingolipid desaturase from Aquilegia vulgaris

A - Papers appearing in refereed journals

Michaelson, L. V., Longman, A. J., Sayanova, O. V., Stobart, A. K. and Napier, J. A. 2002. Isolation and characterization of a cDNA encoding a delta8 sphingolipid desaturase from Aquilegia vulgaris. Biochemical Society Transactions. 30 (6), pp. 1073-1075. https://doi.org/10.1042/bst0301073

The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase

A - Papers appearing in refereed journals

Han, G., Gable, K., Kohlwein, S. D., Beaudoin, F., Napier, J. A. and Dunn, T. M. 2002. The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase. Journal of Biological Chemistry. 277, pp. 35440-35449. https://doi.org/10.1074/jbc.M205620200

A new class of lipid desaturases: identification of the delta4 sphingoid base desaturase

A - Papers appearing in refereed journals

Garton, S., Michaelson, L. V., Beaudoin, F. and Napier, J. A. 2002. A new class of lipid desaturases: identification of the delta4 sphingoid base desaturase. Biochemical Society Transactions. 30 (6), p. A122. https://doi.org/10.1042/bst030a122c

Targeting and membrane-insertion of a sunflower oleosin in vitro and in Saccharomyces cerevisiae : the central hydrophobic domain contains more than one signal sequence, and directs oleosin insertion into the endoplasmic reticulum membrane using a signal anchor sequence mechanism

A - Papers appearing in refereed journals

Beaudoin, F. and Napier, J. A. 2002. Targeting and membrane-insertion of a sunflower oleosin in vitro and in Saccharomyces cerevisiae : the central hydrophobic domain contains more than one signal sequence, and directs oleosin insertion into the endoplasmic reticulum membrane using a signal anchor sequence mechanism. Planta. 215, pp. 293-303.

A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase

A - Papers appearing in refereed journals

Beaudoin, F., Gable, K., Sayanova, O. V., Dunn, T. and Napier, J. A. 2002. A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase. Journal of Biological Chemistry. 277, pp. 11481-11488.

Plant protein families and their relationships to food allergy

A - Papers appearing in refereed journals

Shewry, P. R., Beaudoin, F., Jenkins, J., Griffiths-Jones, S. and Mills, E. N. C. 2002. Plant protein families and their relationships to food allergy. Biochemical Society Transactions. 30 (6), pp. 906-910. https://doi.org/10.1042/bst0300906

Identification of SnIP1, a novel protein that interacts with SNF1-related protein kinase (SnRK1)

A - Papers appearing in refereed journals

Slocombe, S. P., Laurie, S., Bertini, L., Beaudoin, F., Dickinson, J. R. and Halford, N. G. 2002. Identification of SnIP1, a novel protein that interacts with SNF1-related protein kinase (SnRK1). Plant Molecular Biology. 49, pp. 31-44.

The production of gamma-linolenic acid in transgenic plants: further studies on the borage delta6-fatty acid desaturase

C1 - Edited contributions to conferences/learned societies

Sayanova, O. V., Beaudoin, F., Libisch, B., Shewry, P. R. and Napier, J. A. 2001. The production of gamma-linolenic acid in transgenic plants: further studies on the borage delta6-fatty acid desaturase. Huang, Y. S. and Ziboh, A. (ed.) Gamma-linolenic acid: recent advances in biotechnology and clinical applications . American Oil Chemists' Society (AOCS) Press, Champaign, Illinois. pp. 24-28

Mutagenesis and heterologous expression in yeast of a plant delta6-fatty acid desaturase

A - Papers appearing in refereed journals

Sayanova, O. V., Beaudoin, F., Libisch, B., Castel, A., Shewry, P. R. and Napier, J. A. 2001. Mutagenesis and heterologous expression in yeast of a plant delta6-fatty acid desaturase. Journal of Experimental Botany. 52, pp. 1581-1585.

The seed oleosins: structure, properties and biological role

A - Papers appearing in refereed journals

Napier, J. A., Beaudoin, F., Tatham, A. S., Alexander, L. G. and Shewry, P. R. 2001. The seed oleosins: structure, properties and biological role. Advances in botanical research. 35, pp. 111-138. https://doi.org/10.1016/S0065-2296(01)35005-X

Towards the production of pharmaceutical fatty acids in transgenic plants

A - Papers appearing in refereed journals

Napier, J. A. and Michaelson, L. V. 2001. Towards the production of pharmaceutical fatty acids in transgenic plants. Journal of the Science of Food and Agriculture. 81, pp. 883-888.

Genomic and functional characterization of polyunsaturated fatty acid biosynthesis in Caenorhabditis elegans

A - Papers appearing in refereed journals

Napier, J. A. and Michaelson, L. V. 2001. Genomic and functional characterization of polyunsaturated fatty acid biosynthesis in Caenorhabditis elegans. Lipids. 36, pp. 761-766.

Amino acid sequence and molecular modelling of a lipid transfer protein from sunflower (Helianthus annus L.) seeds

A - Papers appearing in refereed journals

Luckett, S., Sessions, R. B., Michaelson, L. V., Naldrett, M. J., Clarke, A. R., Fido, R. J., Tatham, A. S. and Shewry, P. R. 2001. Amino acid sequence and molecular modelling of a lipid transfer protein from sunflower (Helianthus annus L.) seeds. Protein And Peptide Letters. 8, pp. 241-248.

Desaturase (Patent EP 1042485 A2)

H2 - Patents applied for

Napier, J. A., Michaelson, L. V. and Stobart, K. 2000. Desaturase (Patent EP 1042485 A2). EP 1042485 A2

The targeting and accumulation of ectopically expressed oleosin in non-seed tissues of Arabidopsis thaliana

A - Papers appearing in refereed journals

Beaudoin, F. and Napier, J. A. 2000. The targeting and accumulation of ectopically expressed oleosin in non-seed tissues of Arabidopsis thaliana. Planta. 210 (3), pp. 439-445. https://doi.org/10.1007/pl00008152

In vivo targeting of a sunflower oil body protein in yeast secretory (sec) mutants

A - Papers appearing in refereed journals

Beaudoin, F., Wilkinson, B. M., Stirling, C. J. and Napier, J. A. 2000. In vivo targeting of a sunflower oil body protein in yeast secretory (sec) mutants. The Plant Journal. 23 (2), pp. 159-170. https://doi.org/10.1046/j.1365-313x.2000.00769.x

Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway

A - Papers appearing in refereed journals

Beaudoin, F., Michaelson, L. V., Hey, S. J., Lewis, M. J., Shewry, P. R., Sayanova, O. V. and Napier, J. A. 2000. Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway. Proceedings of the National Academy of Sciences. 97 (12), pp. 6421-6426. https://doi.org/10.1073/pnas.110140197

Mutagenesis of the borage delta 6 fatty acid desaturase

A - Papers appearing in refereed journals

Sayanova, O. V., Beaudoin, F., Libisch, B., Shewry, P. R. and Napier, J. A. 2000. Mutagenesis of the borage delta 6 fatty acid desaturase. Biochemical Society Transactions. 28 (6), pp. 636-638. https://doi.org/10.1042/bst0280636

An unusual desaturase in Aquilegia vulgaris

A - Papers appearing in refereed journals

Longman, A. J., Michaelson, L. V., Sayanova, O. V., Napier, J. A. and Stobart, A. K. 2000. An unusual desaturase in Aquilegia vulgaris. Biochemical Society Transactions. 28 (6), pp. 641-643. https://doi.org/10.1042/bst0280641

Chimeras of delta6-fatty acid and delta8-sphingolipid desaturases

A - Papers appearing in refereed journals

Libisch, B., Michaelson, L. V., Lewis, M. J., Shewry, P. R. and Napier, J. A. 2000. Chimeras of delta6-fatty acid and delta8-sphingolipid desaturases. Biochemical and Biophysical Research Communications. 279 (3), pp. 779-785. https://doi.org/10.1006/bbrc.2000.4023

Production of C20 polyunsaturated fatty acids (PUFAs) by pathway engineering: identification of a PUFA elongase component from Caenorhabditis elegans

A - Papers appearing in refereed journals

Beaudoin, F., Michaelson, L. V., Lewis, M. J., Shewry, P. R., Sayanova, O. V. and Napier, J. A. 2000. Production of C20 polyunsaturated fatty acids (PUFAs) by pathway engineering: identification of a PUFA elongase component from Caenorhabditis elegans. Biochemical Society Transactions. 28 (6), pp. 661-663. https://doi.org/10.1042/bst0280661

Hordeum vulgare mRNA for SnRK1-interacting protein 1

K - Protein or DNA sequences submitted to database

Slocombe, S. P., Bertini, L., Beaudoin, F., Dickinson, J. R. and Halford, N. G. 2000. Hordeum vulgare mRNA for SnRK1-interacting protein 1.

Hordeum vulgare snipla gene, partial

K - Protein or DNA sequences submitted to database

Slocombe, S. P., Bertini, L., Beaudoin, F., Dickinson, J. R. and Halford, N. G. 2000. Hordeum vulgare snipla gene, partial.

Desaturase (Patent WO 1999/033958 A2 )

H2 - Patents applied for

Napier, J. A., Michaelson, L. V. and Stobart, K. 1999. Desaturase (Patent WO 1999/033958 A2 ) . WO 1999/033958 A2

The biogenesis of the plant seed oil body: Oleosin protein is synthesised by ER-bound ribosomes

A - Papers appearing in refereed journals

Beaudoin, F., Lacey, D. J. and Napier, J. A. 1999. The biogenesis of the plant seed oil body: Oleosin protein is synthesised by ER-bound ribosomes. Plant Physiology and Biochemistry. 37 (6), pp. 481-490. https://doi.org/10.1016/s0981-9428(99)80053-9

The accumulation of triacylglycerols within the endoplasmic reticulum of developing seeds of Helianthus annuus

A - Papers appearing in refereed journals

Lacey, D. J., Beaudoin, F., Dempsey, C. E., Shewry, P. R. and Napier, J. A. 1999. The accumulation of triacylglycerols within the endoplasmic reticulum of developing seeds of Helianthus annuus. The Plant Journal. 17 (4), pp. 397-405. https://doi.org/10.1046/j.1365-313X.1999.00387.x

Plant desaturases: harvesting the fat of the land

A - Papers appearing in refereed journals

Napier, J. A., Michaelson, L. V. and Stobart, A. K. 1999. Plant desaturases: harvesting the fat of the land. Current Opinion in Plant Biology. 2 (2), pp. 123-127. https://doi.org/10.1016/s1369-5266(99)80025-9

Secondary structure of oleosins in oil bodies isolated from seeds of safflower (Carthamus tinctorius L.) and sunflower (Helianthus annuus L.)

A - Papers appearing in refereed journals

Lacey, D. J., Wellner, N., Beaudoin, F., Napier, J. A. and Shewry, P. R. 1998. Secondary structure of oleosins in oil bodies isolated from seeds of safflower (Carthamus tinctorius L.) and sunflower (Helianthus annuus L.). Biochemical Journal. 334, pp. 469-477.

Isolation of a Delta(5)-fatty acid desaturase gene from Mortierella alpina

A - Papers appearing in refereed journals

Michaelson, L. V., Lazarus, C. M., Griffiths, G., Napier, J. A. and Stobart, A. K. 1998. Isolation of a Delta(5)-fatty acid desaturase gene from Mortierella alpina. Journal of Biological Chemistry. 273 (30), pp. 19055-19059. https://doi.org/10.1074/jbc.273.30.19055

Functional identification of a fatty acid Delta 5 desaturase gene from Caenorhabditis elegans

A - Papers appearing in refereed journals

Michaelson, L. V., Napier, J. A., Lewis, M., Griffiths, G., Lazarus, C. M. and Stobart, A. K. 1998. Functional identification of a fatty acid Delta 5 desaturase gene from Caenorhabditis elegans. FEBS Letters. 439 (3), pp. 215-218. https://doi.org/10.1016/s0014-5793(98)01385-4

Hordeum vulgare mRNA for SnRK1-type protein kinase, partial

K - Protein or DNA sequences submitted to database

Slocombe, S. P., Bertini, L., Beaudoin, F., Dickinson, J. R. and Halford, N. G. 1998. Hordeum vulgare mRNA for SnRK1-type protein kinase, partial.