Tolerance to oxidative stress is associated with both oxidative stress response and inherent growth in a fungal wheat pathogen

A - Papers appearing in refereed journals

Zhong, Z., MacDonald, B. A. and Palma-Guerrero, J. 2020. Tolerance to oxidative stress is associated with both oxidative stress response and inherent growth in a fungal wheat pathogen . Genetics. p. iyaa022. https://doi.org/10.1093/genetics/iyaa022

AuthorsZhong, Z., MacDonald, B. A. and Palma-Guerrero, J.
Abstract

Reactive oxygen species (ROS) are toxic byproducts of aerobic respiration that are also important in mediating a diversity of cellular functions. ROS form an important component of plant defenses to inhibit microbial pathogens during pathogen-plant interactions. Tolerance to oxidative stress is likely to make a significant contribution to the viability and pathogenicity of plant pathogens, but the complex network of oxidative stress responses hinders identification of the genes contributing to this trait. Here, we employed a forward genetic approach to investigate the genetic architecture of oxidative stress tolerance in the fungal wheat pathogen Zymoseptoria tritici. We used quantitative trait locus (QTL) mapping of growth and melanization under axenic conditions in two cross populations to identify genomic regions associated with tolerance to oxidative stress. We found that QTLs associated with growth under oxidative stress as well as inherent growth can affect oxidative stress tolerance, and we identified two uncharacterized genes in our QTL associated with this trait. Our data suggest that melanization does not affect tolerance to oxidative stress, which differs from what was found for animal pathogens. This study provides a whole-genome perspective on the genetic basis of oxidative stress tolerance in a plant pathogen.

KeywordsQuantitative trait locus mapping; Oxidative stress; Plant pathogen; Fungi; Zymoseptoria tritici
Year of Publication2020
JournalGenetics
Journal citationp. iyaa022
Digital Object Identifier (DOI)https://doi.org/10.1093/genetics/iyaa022
Open accessPublished as ‘gold’ (paid) open access
FunderBiotechnology and Biological Sciences Research Council
Accepted author manuscript
Output statusPublished
Publication dates
Online10 Dec 2020
Publication process dates
Accepted23 Nov 2020
PublisherGenetics Society of America (GSA)
ISSN0016-6731

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