Metabolic profling of cytotoxic metabolites from fve Tabebuia species supported by molecular correlation analysis

A - Papers appearing in refereed journals

El-Hawary, S. S., Mohammed, R., Tawfike, A., AbouZid, S. F., Taher, M. A., Abdelmohsen, U. R. and Amin, E. 2021. Metabolic profling of cytotoxic metabolites from fve Tabebuia species supported by molecular correlation analysis. Scientific Reports. 11, p. 8405. https://doi.org/10.1038/s41598-021-87695-w

AuthorsEl-Hawary, S. S., Mohammed, R., Tawfike, A., AbouZid, S. F., Taher, M. A., Abdelmohsen, U. R. and Amin, E.
Abstract

Tabebuia is the largest genus among the family Bignoniaceae. Tabebuia species are known for their high ornamental and curative value. Here, the cytotoxic potential of extracts from the leaves and stems of fve Tabebuia species was analyzed. The highest activity was observed for T. rosea
(Bertol.) DC. stem extract against HepG2 cell line (IC50 4.7 µg/mL), T. pallida L. stem extract against MCF-7 cell line (IC50 6.3 µg/mL), and T. pulcherrima stem extract against CACO2 cell line (IC50 2.6 µg/mL). Metabolic profiling of the ten extracts using liquid chromatography–high-resolution mass
spectrometry for dereplication purposes led to annotation of forty compounds belonging to diferent chemical classes. Among the annotated compounds, irridoids represent the major class. Principle component analysis (PCA) was applied to test the similarity and variability among the tested species and the score plot showed similar chemical profling between the leaves and stems of both T. pulcherrima and T. pallida L. and unique chemical profling among T. rosea (Bertol.) DC., T. argentea Britton, and T. guayacan (Seem.) Hemsl. leaf extracts and the stem extract of T. rosea (Bertol.) DC. Additionally, a molecular correlation analysis was used to annotate the bioactive cytotoxic metabolites in the extracts and correlate between their chemical and biological profles.

Year of Publication2021
JournalScientific Reports
Journal citation11, p. 8405
Digital Object Identifier (DOI)https://doi.org/10.1038/s41598-021-87695-w
Open accessPublished as ‘gold’ (paid) open access
FunderBiotechnology and Biological Sciences Research Council
Publisher's version
Output statusPublished
Publication dates
Online16 Apr 2021
Publication process dates
Accepted23 Mar 2021
PublisherNature Publishing Group
ISSN2045-2322

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