Cytotoxic activity of actinomycetes Nocardia sp. and Nocardiopsis sp. associated with marine sponge Amphimedon sp.
A - Papers appearing in refereed journals
Shady, N. H., Tawfike, A., Yahia, R., Fouad, M. A., Brachmann, A. O. and Piel, J. 2021. Cytotoxic activity of actinomycetes Nocardia sp. and Nocardiopsis sp. associated with marine sponge Amphimedon sp. Natural Product Research. https://doi.org/10.1080/14786419.2021.1931865
| Authors | Shady, N. H., Tawfike, A., Yahia, R., Fouad, M. A., Brachmann, A. O. and Piel, J. |
|---|---|
| Abstract | Cancer is a hazard life-threatening disease, which affect huge population worldwide. Marine actinomycetes are considered as promising source for potential chemotherapeutic agents. In our study, we carried out metabolic profiling for Nocardia sp. UR 86 and Nocardiopsis sp. UR 92 that were cultivated from the Red Sea sponge Amphimedon sp. to investigate their chemical diversity using different media conditions. The crude culture extracts were subjected to high-resolution mass spectrometry (HRMS) analysis. The chemical profiles of the different extracts of Nocardia sp. UR 86 and Nocardiopsis sp. UR 92 revealed their richness in diverse metabolites and consequently twenty compounds (1–20) were annotated. Moreover, the obtained extracts of the differently cultivated Nocardia sp. UR 86 and Nocardiopsis sp. UR 92 were investigated against three cell lines HepG2, MCF-7 and CACO2 and revealed the targeted cytotoxicity of Nocardia sp. and Nocardiopsis sp. metabolites against the three cell lines |
| Keywords | Nocardia sp; Nocardiopsis sp; Amphimedon sp; Cytotoxic; Metabolic profiling |
| Year of Publication | 2021 |
| Journal | Natural Product Research |
| Digital Object Identifier (DOI) | https://doi.org/10.1080/14786419.2021.1931865 |
| Open access | Published as non-open access |
| Output status | Published |
| Publication dates | |
| Online | 27 May 2021 |
| Publication process dates | |
| Accepted | 14 Apr 2021 |
| Publisher | Taylor & Francis |
| ISSN | 1478-6419 |
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