Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest, Myzus persicae

A - Papers appearing in refereed journals

Singh, K. S., Cordeiro, E. M. G., Troczka, B. J., Pym, A., Mackisack, J., Mathers, T. C., Duarte, A., Legeai, F., Robin, S., Bielza, P., Burrack, H. J., Charaabi, K., Denholm, I., Figueroa, C. C., Ffrench-Constant, R. H., Jander, G., Margaritopoulos, J. T., Mazzoni, E., Nauen, R., Ramirez, C. C., Ren, G., Stepanyan, G., Umina, I., Voronova, N. V., Vontas, J., Williamson, M. S., Wilson, A. C. C., Xi-Wu, G., Youn, Y-N., Zimmer, C. T., Simon, J-C., Hayward, A. and Bass, C. G. 2021. Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest, Myzus persicae. Communications Biology. 4 (1), pp. 847-end. https://doi.org/10.1038/s42003-021-02373-x

AuthorsSingh, K. S., Cordeiro, E. M. G., Troczka, B. J., Pym, A., Mackisack, J., Mathers, T. C., Duarte, A., Legeai, F., Robin, S., Bielza, P., Burrack, H. J., Charaabi, K., Denholm, I., Figueroa, C. C., Ffrench-Constant, R. H., Jander, G., Margaritopoulos, J. T., Mazzoni, E., Nauen, R., Ramirez, C. C., Ren, G., Stepanyan, G., Umina, I., Voronova, N. V., Vontas, J., Williamson, M. S., Wilson, A. C. C., Xi-Wu, G., Youn, Y-N., Zimmer, C. T., Simon, J-C., Hayward, A. and Bass, C. G.
Abstract

The aphid Myzus persicae is a destructive agricultural pest that displays an exceptional ability to develop resistance to both natural and synthetic insecticides. To investigate the evolution of resistance in this species we generated a chromosome-scale genome assembly and living panel of >110 fully sequenced globally sampled clonal lines. Our analyses reveal a remarkable diversity of resistance mutations segregating in global populations of M. persicae. We show that the emergence and spread of these mechanisms is influenced by host-plant associations, uncovering the widespread co-option of a host-plant adaptation that also offers resistance against synthetic insecticides. We identify both the repeated evolution of independent resistance mutations at the same locus, and multiple instances of the evolution of novel resistance mechanisms against key insecticides. Our findings provide fundamental insights into the genomic responses of global insect populations to strong selective forces, and hold practical relevance for the control of pests and parasites.

KeywordsMyzus persicae; Hemiptera; Peach-potato aphid; Sodium channel; Pyrethroid insecticides; Genetic variation; Host races association; Mutation
Year of Publication2021
JournalCommunications Biology
Journal citation4 (1), pp. 847-end
Digital Object Identifier (DOI)https://doi.org/10.1038/s42003-021-02373-x
Web address (URL)https://www.nature.com/articles/s42003-021-02373-x
Open accessPublished as ‘gold’ (paid) open access
FunderEuropean Research Council
Biotechnology and Biological Sciences Research Council
Funder project or codeBB/S006060/1
Publisher's version
Output statusPublished
Publication dates
Online07 Jul 2021
Publication process dates
Accepted17 Jun 2021
PublisherNature Publishing Group
ISSN2399-3642

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