Cold case The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt

A - Papers appearing in refereed journals

De Miranda, J. R., Brettell, L. E., Chejanovsky, N., Childers, A. K., Dalmon, A., Deboutte, W., De Graaf, D. C., Doublet, V., Gebremedhn, H., Genersch, E., Gisder, S., Granberg, F., Haddad, N. J., Kaden, R., Manley, R., Matthijnssens, J., Meeus, I., Migdadi, H., Milbrath, M. O., Mondet, F., Remnant, E. J., Roberts, J. M. K., Ryabov, E. V., Sela, N., Smagghe, G., Somanathan, H., Wilfert, L., Wright, O. N., Martin, S. J. and Ball, B. V. 2022. Cold case The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt. Virology Journal. 19 (1), p. 12. https://doi.org/10.1186/s12985-022-01740-2

AuthorsDe Miranda, J. R., Brettell, L. E., Chejanovsky, N., Childers, A. K., Dalmon, A., Deboutte, W., De Graaf, D. C., Doublet, V., Gebremedhn, H., Genersch, E., Gisder, S., Granberg, F., Haddad, N. J., Kaden, R., Manley, R., Matthijnssens, J., Meeus, I., Migdadi, H., Milbrath, M. O., Mondet, F., Remnant, E. J., Roberts, J. M. K., Ryabov, E. V., Sela, N., Smagghe, G., Somanathan, H., Wilfert, L., Wright, O. N., Martin, S. J. and Ball, B. V.
Abstract

In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstrate that Egypt bee virus is in fact a fourth unique, major variant of DWV (DWV-D): more closely related to DWV-C than to either DWV-A or DWV-B. DWV-A and DWV-B are the most common DWV variants worldwide due to their close relationship and transmission by Varroa destructor. However, we could not find any trace of DWV-D in several hundred RNA sequencing libraries from a worldwide selection of honeybee, varroa and bumblebee samples. This means that DWV-D has either become extinct, been replaced by other DWV variants better adapted to varroa-mediated transmission, or persists only in a narrow geographic or host range, isolated from common bee and beekeeping trade routes.

Year of Publication2022
JournalVirology Journal
Journal citation19 (1), p. 12
Digital Object Identifier (DOI)https://doi.org/10.1186/s12985-022-01740-2
Open accessPublished as ‘gold’ (paid) open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeBB/M009122/1
Publisher's version
Output statusPublished
Publication dates
Online15 Jan 2022
Publication process dates
Accepted31 Dec 2021
ISSN1743-422X
PublisherBiomed Central Ltd

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