Low asparagine wheat - Europe’s first field trial of genome edited wheat amid rapidly changing regulations on acrylamide in food and genome editing of crops

A - Papers appearing in refereed journals

Kaur, N., Brock, T., Raffan, S. and Halford, N. G. 2024. Low asparagine wheat - Europe’s first field trial of genome edited wheat amid rapidly changing regulations on acrylamide in food and genome editing of crops. Breeding Science. 74, pp. 37-46. https://doi.org/10.1270/jsbbs.23058

AuthorsKaur, N., Brock, T., Raffan, S. and Halford, N. G.
Abstract

We review the undertaking of a field trial of low asparagine wheat lines in which the asparagine synthetase gene, TaASN2, has been knocked out using CRISPR/Cas9. The field trial was undertaken in 2021-2022 and represented the first field release of genome edited wheat in Europe. The year of the field trial and the period since have seen rapid changes in the regulations covering both the field release and commercialisation of genome edited crops in the UK. These historic developments are reviewed in detail. Free asparagine is the precursor for acrylamide formation during high-temperature cooking and processing of grains, tubers, storage roots, beans and other crop products. Consequently, work on reducing the free asparagine concentration of wheat and other cereal grains, as well as the tubers, beans and storage roots of other crops, is driven by the need for food businesses to comply with current and potential future regulations on acrylamide content of foods. The topic illustrates how strategic and applied crop research is driven by regulations and also needs a supportive regulatory environment in which to thrive.

KeywordsAcrylamide; Asparagine; CRISPR; Food safety; Precision breeding organisms; Processing contaminants; Wheat
Year of Publication2024
JournalBreeding Science
Journal citation74, pp. 37-46
Digital Object Identifier (DOI)https://doi.org/10.1270/jsbbs.23058
Web address (URL)https://www.jstage.jst.go.jp/article/jsbbs/advpub/0/advpub_23058/_article/-char/en
Open accessPublished as ‘gold’ (paid) open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeDefining the signalling network linking pathogen infection and asparagine accumulation in wheat grain
SWBio DTP PhD studentship
Field assessment of ultra-low asparagine, low acrylamide, gene edited wheat
Publisher's version
Accepted author manuscript
Output statusPublished
Publication dates
Online20 Mar 2024
Publication process dates
Accepted18 Jan 2024
PublisherJ-Stage
ISSN1347-3735

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