A - Papers appearing in refereed journals
Kaur, N., Brock, T., Raffan, S. and Halford, N. G. 2024. Low asparagine wheat - Europe’s first field trial of genome edited wheat amid rapidly changing regulations on acrylamide in food and genome editing of crops. Breeding Science. 74, pp. 37-46. https://doi.org/10.1270/jsbbs.23058
Authors | Kaur, N., Brock, T., Raffan, S. and Halford, N. G. |
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Abstract | We review the undertaking of a field trial of low asparagine wheat lines in which the asparagine synthetase gene, TaASN2, has been knocked out using CRISPR/Cas9. The field trial was undertaken in 2021-2022 and represented the first field release of genome edited wheat in Europe. The year of the field trial and the period since have seen rapid changes in the regulations covering both the field release and commercialisation of genome edited crops in the UK. These historic developments are reviewed in detail. Free asparagine is the precursor for acrylamide formation during high-temperature cooking and processing of grains, tubers, storage roots, beans and other crop products. Consequently, work on reducing the free asparagine concentration of wheat and other cereal grains, as well as the tubers, beans and storage roots of other crops, is driven by the need for food businesses to comply with current and potential future regulations on acrylamide content of foods. The topic illustrates how strategic and applied crop research is driven by regulations and also needs a supportive regulatory environment in which to thrive. |
Keywords | Acrylamide; Asparagine; CRISPR; Food safety; Precision breeding organisms; Processing contaminants; Wheat |
Year of Publication | 2024 |
Journal | Breeding Science |
Journal citation | 74, pp. 37-46 |
Digital Object Identifier (DOI) | https://doi.org/10.1270/jsbbs.23058 |
Web address (URL) | https://www.jstage.jst.go.jp/article/jsbbs/advpub/0/advpub_23058/_article/-char/en |
Open access | Published as ‘gold’ (paid) open access |
Funder | Biotechnology and Biological Sciences Research Council |
Funder project or code | Defining the signalling network linking pathogen infection and asparagine accumulation in wheat grain |
SWBio DTP PhD studentship | |
Field assessment of ultra-low asparagine, low acrylamide, gene edited wheat | |
Publisher's version | |
Accepted author manuscript | |
Output status | Published |
Publication dates | |
Online | 20 Mar 2024 |
Publication process dates | |
Accepted | 18 Jan 2024 |
Publisher | J-Stage |
ISSN | 1347-3735 |
Permalink - https://repository.rothamsted.ac.uk/item/98y10/low-asparagine-wheat-europe-s-first-field-trial-of-genome-edited-wheat-amid-rapidly-changing-regulations-on-acrylamide-in-food-and-genome-editing-of-crops