Genome-Wide In Silico Analysis of Leucine-Rich Repeat R-Genes in Perilla citriodora: Classification and Expression Insights

Bae, S.-H., Zoclanclounon, Ange, Park, G-H., Lee, J-D. and Kim, T-H. (2025) Genome-Wide In Silico Analysis of Leucine-Rich Repeat R-Genes in Perilla citriodora: Classification and Expression Insights. Genes, 16 (2). p. 200. 10.3390/genes16020200

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Background: Resistance (R) genes are crucial for defending Perilla against pathogens like anthracnose, downy mildew, and phytophthora blight. Nucleotide-binding site leucine-rich repeat (NBS-LRR) genes, the largest R-gene family, play a central role in immunity. This study aimed to identify and characterize NBS-LRR genes in P. citriodora ‘Jeju17’. Methods: Previously conducted genome-wide data for ‘Jeju17’ were analyzed in silico to identify NBS-LRR genes. Results: A total of 535 NBS-LRR genes were identified,with clusters on chromosomes 2, 4, and 10. A unique RPW8-type R-gene was located on chromosome 7.

Conclusions: This study provides insights into the NBS-LRR gene family in ‘Je-ju17’, highlighting its role in disease resistance and evolutionary dynamics. By identifying candidate R-genes, this research supports breeding programs to develop disease-resistant cultivars and improves our understanding of plant immunity.

Item Type	Article
Open Access	Gold
Additional information	contribution to this publication was prior to Ange's employment at RRes Funding: This work was conducted with support from “the Cooperative Research Program for PostGenome (PJ013355)”, Rural Development Administration (RDA), Republic of Korea.
Keywords	Disease resistance, Nucleotide-binding site leucine-rich repeat (NBS-LRR), Resistance genes (R-genes), Genomic distribution, Tissue-specific expression, Perilla citriodora genome
Date Deposited	05 Dec 2025 10:45
Last Modified	19 Dec 2025 14:58