PS: Lipid Metabolic Engineering and Synthetic Biology
| Title | PS: Lipid Metabolic Engineering and Synthetic Biology |
|---|---|
| Type | Research cluster |
Outputs
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Impairment of DHA synthesis alters the expression of neuronal plasticity markers and the brain inflammatory status in mice
A - Papers appearing in refereed journals
Talamonti, E., Sasso, V., To, H., Haslam, R. P., Napier, J. A., Ulfhake, B., Pernold, K., Asadi, A., Hessa, T., Jacobsson, A., Chiurchiu, V. and Viscomi, M. T. 2020. Impairment of DHA synthesis alters the expression of neuronal plasticity markers and the brain inflammatory status in mice. The FASEB Journal. 34 (2), pp. 2024-2040. https://doi.org/10.1096/fj.201901890RR
DES2 is a fatty acid Delta 11 desaturase capable of synthesizing palmitvaccenic acid in the arbuscular mycorrhizal fungus Rhizophagus irregularis
A - Papers appearing in refereed journals
Cheeld, H., Bhutada, G., Beaudoin, F. and Eastmond, P. J. 2020. DES2 is a fatty acid Delta 11 desaturase capable of synthesizing palmitvaccenic acid in the arbuscular mycorrhizal fungus Rhizophagus irregularis. FEBS Letters. https://doi.org/10.1002/1873-3468.13762
Identification of a Δ11 desaturase from the arbuscular mycorrhizal fungus Rhizophagus irregularis
A - Papers appearing in refereed journals
Cheeld, H., Bhutada, G., Beaudoin, F. and Eastmond, P. J. 2020. Identification of a Δ11 desaturase from the arbuscular mycorrhizal fungus Rhizophagus irregularis. bioRxiv. https://doi.org/10.1101/2020.01.13.903815
Metabolic Engineering and Synthetic Biology Approaches to Enhancing Production of Long-Chain Polyunsaturated Fatty acids in Microalgae
B - Book chapters etc edited externally
Khozin-Goldberg, I. and Sayanova, O. V. 2020. Metabolic Engineering and Synthetic Biology Approaches to Enhancing Production of Long-Chain Polyunsaturated Fatty acids in Microalgae. in: Hallmann, A. and Rampelotto, P. (ed.) Grand Challenges in Algae Biotechnology. Grand Challenges in Biology and Biotechnology. Springer. pp. 249-289
Nutritional enhancement in plants – green and greener
A - Papers appearing in refereed journals
Napier, J. A. and Sayanova, O. V. 2020. Nutritional enhancement in plants – green and greener. Current Opinion in Biotechnology. 61 (February), pp. 122-127. https://doi.org/10.1016/j.copbio.2019.12.010
Characterisation of Oil Palm Acyl-CoA-Binding Proteins and Correlation of their Gene Expression with Oil Synthesis
A - Papers appearing in refereed journals
Amiruddin, N., Chan, P-K., Azizi, N., Morris, P. E., Cham, K-L., Ong, P. W., Rosli, R., Masura, S. S., Murphy, D. J., Sambanthamurthi, R., Haslam, R. P., Chye, M-L., Harwood, J. L. and Low, E-T. L. 2019. Characterisation of Oil Palm Acyl-CoA-Binding Proteins and Correlation of their Gene Expression with Oil Synthesis. Plant and cell physiology. 61, pp. 735-747. https://doi.org/10.1093/pcp/pcz237
Arabidopsis cytosolic acyl-CoA-binding proteins function in determining seed oil composition
A - Papers appearing in refereed journals
Guo, Z. H., Ye, Z. W., Haslam, R. P., Michaelson, L. V., Napier, J. A. and Chye, M. L. 2019. Arabidopsis cytosolic acyl-CoA-binding proteins function in determining seed oil composition. Plant Direct. 3 (12), p. e00182. https://doi.org/10.1002/pld3.182
The overexpression of rice ACYL-CoA-BINDING PROTEIN2 increases grain size and bran oil content in transgenic rice
A - Papers appearing in refereed journals
Guo, Z.-H., Haslam, R. P., Michaelson, L. V., Young, E. C., Lung, S. C., Napier, J. A. and Chye, M.L. 2019. The overexpression of rice ACYL-CoA-BINDING PROTEIN2 increases grain size and bran oil content in transgenic rice. The Plant Journal. https://doi.org/10.1111/tpj.14503
Engineering the stereoisomeric structure of seed oil to mimic human milk fat
A - Papers appearing in refereed journals
Van-Erp, H., Bryant, F. M., Martin-Moreno, J., Michaelson, L. V., Bhutada, G. and Eastmond, P. J. 2019. Engineering the stereoisomeric structure of seed oil to mimic human milk fat. Proceedings of the National Academy of Sciences. 116 (42), pp. 20947-20952. https://doi.org/10.1073/pnas.1907915116
Phosphorus Use Efficiency and Fertilizers: future opportunities for improvements
A - Papers appearing in refereed journals
Blackwell, M. S. A., Darch, T. and Haslam, R. P. 2019. Phosphorus Use Efficiency and Fertilizers: future opportunities for improvements. Frontiers of Agricultural Science and Engineering - FASE. 6 (4), pp. 332-340. https://doi.org/10.15302/J-FASE-2019274
Multifunctionalizing the marine diatom Phaeodactylum tricornutum for sustainable co-production of omega-3 long chain polyunsaturated fatty acids and recombinant phytase
A - Papers appearing in refereed journals
Pudney, A., Gandini, C., Economou, C., Smith, Richard T., Goddard, P., Napier, J. A., Spicer, A. and Sayanova, O. V. 2019. Multifunctionalizing the marine diatom Phaeodactylum tricornutum for sustainable co-production of omega-3 long chain polyunsaturated fatty acids and recombinant phytase. Scientific Reports. 9 (1), p. 11444. https://doi.org/10.1038/s41598-019-47875-1
Sphingolipids: towards an integrated view of metabolism during the plant stress response
A - Papers appearing in refereed journals
Huby, E., Napier, J. A., Baillieul, F., Michaelson, L. V. and Dhondt-Cordelier, S. 2019. Sphingolipids: towards an integrated view of metabolism during the plant stress response. New Phytologist. https://doi.org/10.1111/nph.15997
The challenges of delivering genetically modified crops with nutritional enhancement traits
A - Papers appearing in refereed journals
Napier, J. A., Haslam, R. P., Tsalavouta, M. and Sayanova, O. V. 2019. The challenges of delivering genetically modified crops with nutritional enhancement traits. Nature Plants. 5, pp. 563-567. https://doi.org/10.1038/s41477-019-0430-z
Postprandial incorporation of EPA and DHA from transgenic Camelina sativa oil into blood lipids is equivalent to that from fish oil in healthy humans
A - Papers appearing in refereed journals
West, A. L., Miles, E.A., Lillycrop K. A., Han, L., Sayanova, O. V., Napier, J. A. and Calder, P. C. 2019. Postprandial incorporation of EPA and DHA from transgenic Camelina sativa oil into blood lipids is equivalent to that from fish oil in healthy humans. British Journal Of Nutrition. pp. 1-27. https://doi.org/10.1017/S0007114519000825
Update on GM canola crops as novel sources of omega-3 fish oils
A - Papers appearing in refereed journals
Napier, J. A., Olsen, R-E. and Tocher, D. R. 2019. Update on GM canola crops as novel sources of omega-3 fish oils. Plant Biotechnology Journal. 17 (4), pp. 703-705. https://doi.org/10.1111/pbi.13045
Omega-3 Long-Chain Polyunsaturated Fatty Acids, EPA and DHA: Bridging the Gap between Supply and Demand Nutrients
A - Papers appearing in refereed journals
Tocher, D. R., Betancor, M. B., Sprague, M., Olsen, R. E. and Napier, J. A. 2019. Omega-3 Long-Chain Polyunsaturated Fatty Acids, EPA and DHA: Bridging the Gap between Supply and Demand Nutrients . Nutrients. 11 (1), p. 89. https://doi.org/10.3390/nu11010089
Oat and lipolysis: Food matrix effect
A - Papers appearing in refereed journals
Wilde, P. J., Garcia-Llatas, G., Lagarda, M. J, Haslam, R. P. and Grundy, M. M. L. 2019. Oat and lipolysis: Food matrix effect. Food Chemistry. 278 (25 April), pp. 683-691. https://doi.org/10.1016/j.foodchem.2018.11.113
Impact of heat processing on the nutritional content of Gryllus bimaculatus (black cricket)
A - Papers appearing in refereed journals
Dobermann, D., Field, L. M. and Michaelson, L. V. 2019. Impact of heat processing on the nutritional content of Gryllus bimaculatus (black cricket). Nutrition Bulletin. pp. 1-7. https://doi.org/10.1111/nbu.12374
Ectomycorrhizal inoculation with Pisolithus tinctorius reduces stress induced by drought in cork oak
A - Papers appearing in refereed journals
Sebastiana, M., Bernardes da Silva, A, Alcantara, A., Silvestre, S. and Malhó, R. 2018. Ectomycorrhizal inoculation with Pisolithus tinctorius reduces stress induced by drought in cork oak. Mycorrhiza. 28 (3), pp. 247-258. https://doi.org/10.1007/s00572-018-0823-2
Transgenic Microalgae With Increased Production Of At Least One Omega-3 Long Chain Polyunsaturated Fatty Acid (Patent US 2018/0312888 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V., Hamilton, M. L. and Vaezi, R. 2018. Transgenic Microalgae With Increased Production Of At Least One Omega-3 Long Chain Polyunsaturated Fatty Acid (Patent US 2018/0312888 A1) . US 2018/0312888 A1
Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent) CA 2744930 C
H2 - Patents applied for
Napier, J. A., Senger, T. and Bauer, J. 2018. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent) CA 2744930 C. CA 2744930 C
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent CA 2621214 C)
H1 - Patents granted
Napier, J. A. and Sayanova, O. V. 2018. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent CA 2621214 C). CA 2621214 C
Analysis of Metals in Whole Cells, Thylakoids and Photosynthetic Protein Complexes in Synechocystis sp. PCC6803
A - Papers appearing in refereed journals
Gandini, C., Husted, S. and Schmidt, S. B. 2018. Analysis of Metals in Whole Cells, Thylakoids and Photosynthetic Protein Complexes in Synechocystis sp. PCC6803 . Bio-protocol. 8 (12). https://doi.org/10.21769/BioProtoc.2889
Europe’s first and last field trial of gene-edited plants?
A - Papers appearing in refereed journals
Faure, J-D. and Napier, J. A. 2018. Europe’s first and last field trial of gene-edited plants? eLife. 7 (e42379). https://doi.org/10.7554/eLife.42379
Using Hermetia illucens to process Ugandan waragi waste
A - Papers appearing in refereed journals
Dobermann, D., Field, L. M. and Michaelson, L. V. 2018. Using Hermetia illucens to process Ugandan waragi waste . Journal of Cleaner Production. 211 (20 February), pp. 303-308. https://doi.org/10.1016/j.jclepro.2018.11.176
The effect of an initial high-quality feeding regime on the survival of Gryllus bimaculatus (black cricket) on bio-waste
A - Papers appearing in refereed journals
Dobermann, D., Michaelson, L. V. and Field, L. M. 2018. The effect of an initial high-quality feeding regime on the survival of Gryllus bimaculatus (black cricket) on bio-waste. Journal of Insects as Food and Feed. 5 (2), pp. 117-123. https://doi.org/10.3920/JIFF2018.0024
Response of cell wall composition and RNA-seq transcriptome to methyl-jasmonate in Brachypodium distachyon callus
A - Papers appearing in refereed journals
Hyde, L. S., Pellny, T. K., Freeman, J., Michaelson, L. V., Simister, R., McQueen-Mason, S. J. and Mitchell, R. A. C. 2018. Response of cell wall composition and RNA-seq transcriptome to methyl-jasmonate in Brachypodium distachyon callus . Planta. 248 (5), pp. 1213-1229. https://doi.org/10.1007/s00425-018-2968-9
Oil from transgenic Camelina sativa containing over 25 % n-3 long-chain PUFA as the major lipid source in feed for Atlantic salmon (Salmo salar)
A - Papers appearing in refereed journals
Betancor, M. B., Li, K., Bucerzan, V. S., Sprague, M., Sayanova, O. V., Usher, S. L., Han, L., Norambuena, F., Torrissen, O., Napier, J. A., Tocher, D. R. and Olsen, R. E. 2018. Oil from transgenic Camelina sativa containing over 25 % n-3 long-chain PUFA as the major lipid source in feed for Atlantic salmon (Salmo salar). British Journal Of Nutrition. 119 (12), pp. 1378-1392. https://doi.org/10.1017/S0007114518001125
New insights in the composition of wax and sterol esters in common and mutant sunflower oils revealed by ESI-MS/MS
A - Papers appearing in refereed journals
Broughton, R., Ruíz-Lopez, N., Hassall, K. L., Martínez-Force, E., Garcés, R., Salas, J. J. and Beaudoin, F. 2018. New insights in the composition of wax and sterol esters in common and mutant sunflower oils revealed by ESI-MS/MS. Food Chemistry. 269, pp. 70-79. https://doi.org/10.1016/j.foodchem.2018.06.135
Structural and functional analyses of Rubisco from arctic diatom species reveal unusual posttranslational modifications
A - Papers appearing in refereed journals
Valegård, K., Andralojc, P. J., Haslam, R. P., Pearce, F. G., Erikson, G. K., Madgwick P. J., Kristoffersen A. K., van Lun, M., Klein, U., Eilertsen H. C., Parry, M. A. J. and Andersson, I. 2018. Structural and functional analyses of Rubisco from arctic diatom species reveal unusual posttranslational modifications. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.RA118.003518
Overexpression of acetyl-CoA synthetase (ACS) enhances the biosynthesis of neutral lipids and starch in the green microalga Chlamydomonas reinhardtii
A - Papers appearing in refereed journals
Rengel, R., Smith, R. T., Haslam, R. P., Sayanova, O. V., Vila, M. and Leon, R. 2018. Overexpression of acetyl-CoA synthetase (ACS) enhances the biosynthesis of neutral lipids and starch in the green microalga Chlamydomonas reinhardtii. Algal Research. 31, pp. 183-193. https://doi.org/10.1016/j.algal.2018.02.009
Using lipidomics to reveal details of lipid accumulation in developing seeds from oilseed rape (Brassica napus L.)
A - Papers appearing in refereed journals
Haslam, R. P., Cazenave-Gassiot, A., Guschina, I.A., Wenk, M.R., Woodfield, H.K. and Harwood, J.L. 2018. Using lipidomics to reveal details of lipid accumulation in developing seeds from oilseed rape (Brassica napus L.). Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1863 (3), pp. 339-348. https://doi.org/10.1016/j.bbalip.2017.12.010
Suppression of a single BAHD gene in Setaria viridis causes large, stable decreases in cell wall feruloylation and increases biomass digestibility
A - Papers appearing in refereed journals
De Souza, W. R., Martins, P. K., Freeman, J., Pellny, T. K., Michaelson, L. V., Sampaio, B. L., Vinecky, F., Ribeiro, A. P., Da Cunha, B. A. D. B., Kobayashi, A. K., De Oliveira, P. A., Campanha, R. B., Pacheco, T. F., Martarello, D. C. I., Marchiosi, R., Ferrarese-Filho, O., Dos Santos, W. D., Tramontina, R., Squina, F. M., Centeno, D. C., Gaspar, M., Braga, M. R., Tine, M. A. S., Ralph, J., Mitchell, R. A. C. and Molinari, H. B. C. 2018. Suppression of a single BAHD gene in Setaria viridis causes large, stable decreases in cell wall feruloylation and increases biomass digestibility. New Phytologist. 218 (1), pp. 81-93. https://doi.org/10.1111/nph.14970
Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2669380 B1)
H1 - Patents granted
Senger, T., Bauer, J. and Napier, J. A. 2017. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2669380 B1) . EP 2669380 B1
Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 2017/0067070 A1)
H2 - Patents applied for
Bauer, J., Napier, J. A. and Sayanova, O. V. 2017. Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 2017/0067070 A1) . US 2017/0067070 A1
Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent CA 2723072 C)
H1 - Patents granted
Napier, J. A., Bauer, J. and Sayanova, O. 2017. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent CA 2723072 C). CA 2723072 C
Acyltransferases And Uses Therof In Fatty Acid Production (Patent EP 2585603 B1)
H1 - Patents granted
Senger, T., Marty, L., Stymne, S., Lindberg , Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2017. Acyltransferases And Uses Therof In Fatty Acid Production (Patent EP 2585603 B1). EP 2585603 B1
Process For Producing A Polyunsatured Fatty Acid Comprising Arachidonic Acid (Patent EP 2380984 B1)
H1 - Patents granted
Napier, J. A., Sayanova, O. V. and Venegas Caleron, M. 2017. Process For Producing A Polyunsatured Fatty Acid Comprising Arachidonic Acid (Patent EP 2380984 B1). EP 2380984 B1
An oil containing EPA and DHA from transgenic Camelina sativa to replace marine fish oil in feeds for Atlantic salmon (Salmo salar L.): Effects on intestinal transcriptome, histology, tissue fatty acid profiles and plasma biochemistry
A - Papers appearing in refereed journals
Betancor, M. B., Li, K., Sprague, M., Bardal, T., Sayanova, O. V., Usher, S., Han, L., Måsøval, K., Torrissen, O., Napier, J. A., Tocher, D. R. and Olsen, R. E. 2017. An oil containing EPA and DHA from transgenic Camelina sativa to replace marine fish oil in feeds for Atlantic salmon (Salmo salar L.): Effects on intestinal transcriptome, histology, tissue fatty acid profiles and plasma biochemistry. PLOS ONE. 12 (4), p. e0175415. https://doi.org/10.1371/journal.pone.0175415
Effects of Cultivar and Nitrogen Nutrition on the Lipid Composition of Wheat Flour
A - Papers appearing in refereed journals
Min, B., Gonzalez-Thuillier, I., Powers, S. J., Wilde, P. J., Shewry, P. R. and Haslam, R. P. 2017. Effects of Cultivar and Nitrogen Nutrition on the Lipid Composition of Wheat Flour. Journal of Agricultural and Food Chemistry - JAFC. 65 (26), pp. 5427-5434. https://doi.org/10.1021/acs.jafc.7b01437