Fungal respiration: a fusion of standard and alternative components

A - Papers appearing in refereed journals

Joseph-Horne, T., Holloman, D. W. and Wood, P. M. 2001. Fungal respiration: a fusion of standard and alternative components. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1504 (2-3), pp. 179-195. https://doi.org/10.1016/S0005-2728(00)00251-6

AuthorsJoseph-Horne, T., Holloman, D. W. and Wood, P. M.
Abstract

In animals, electron transfer from NADH to molecular oxygen proceeds via large respiratory complexes in a linear respiratory chain. In contrast, most fungi utilise branched respiratory chains. These consist of alternative NADH dehydrogenases, which catalyse rotenone insensitive oxidation of matrix NADH or enable cytoplasmic NADH to be used directly. Many also contain an alternative oxidase that probably accepts electrons directly from ubiquinol. A few fungi lack Complex I. Although the alternative components are non-energy conserving, their organisation within the fungal electron transfer chain ensures that the transfer of electrons from NADH to molecular oxygen is generally coupled to proton translocation through at least one site. The alternative oxidase enables respiration to continue in the presence of inhibitors for ubiquinol:cytochrome c oxidoreductase and cytochrome c oxidase. This may be particularly important for fungal pathogens, since host defence mechanisms often involve nitric oxide, which, whilst being a potent inhibitor of cytochrome c oxidase, has no inhibitory effect on alternative oxidase. Alternative NADH dehydrogenases may avoid the active oxygen production associated with Complex I. The expression and activity regulation of alternative components responds to factors ranging from oxidative stress to the stage of fungal development.

KeywordsMitochondria; Fungus; Mitochondrial electron transport; NAD(P)H:ubiquinone oxidoreductase; Alternative oxidase; Protonmotive force
Year of Publication2001
JournalBiochimica et Biophysica Acta (BBA) - Bioenergetics
Journal citation1504 (2-3), pp. 179-195
Digital Object Identifier (DOI)https://doi.org/10.1016/S0005-2728(00)00251-6
Open accessPublished as bronze (free) open access
Funder project or code422
507
Mode of action of a novel fungicide
Genetic and biochemical mechanisms of fungicidal action, selectivity and resistance
Publisher's version
Output statusPublished
Publication dates
Online05 Mar 2001
Publication process dates
Accepted19 Oct 2000
Copyright licensePublisher copyright
ISSN0005-2728
PublisherElsevier

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