Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials

A - Papers appearing in refereed journals

Griffiths, C. A., Xue, X., Miret-Barrio, J., Salvagiotti, F., Acevedo-Siaca, L. G., Gimeno, J., Reynolds, M. P., Hassall, K., Halsey, K., Puranik, S., Oszvald, M., Kurup, S., Davis, B. G. and Paul, M. J. 2025. Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials. Nature Biotechnology. https://doi.org/10.1038/s41587-025-02611-1

AuthorsGriffiths, C. A., Xue, X., Miret-Barrio, J., Salvagiotti, F., Acevedo-Siaca, L. G., Gimeno, J., Reynolds, M. P., Hassall, K., Halsey, K., Puranik, S., Oszvald, M., Kurup, S., Davis, B. G. and Paul, M. J.
Abstract

Trehalose 6-phosphate (T6P) is an endogenous sugar signal in plants that promotes growth, yet it cannot be introduced directly into crops or fully genetically controlled. Here we show that wheat yields were improved using a timed microdose of a plant-permeable, sunlight-activated T6P signaling precursor, DMNB-T6P, under a variety of agricultural conditions. Under both well-watered and water-stressed conditions over 4 years, DMNB-T6P stimulated yield of three elite varieties. Yield increases were an order of magnitude larger than average annual genetic gains of breeding programs and occurred without additional water or fertilizer. Mechanistic analyses reveal that these benefits arise from increased CO2 fixation and linear electron flow (‘source’) as well as from increased starchy endosperm volume, enhanced grain sieve tube development and upregulation of genes for starch, amino acid and protein synthesis (‘sink’). These data demonstrate a step-change, scalable technology with net benefit to the environment that could provide sustainable yield improvements of diverse staple cereal crops

KeywordsTrehalose 6-phosphate; Wheat yields; Field trials; Source-sink
Year of Publication2025
JournalNature Biotechnology
Digital Object Identifier (DOI)https://doi.org/10.1038/s41587-025-02611-1
Open accessPublished as ‘gold’ (paid) open access
FunderUKRI-BBSRC
Biotechnology and Biological Sciences Research Council
Engineering and Physical Sciences Research Council
Funder project or codeTrehalose signalling: understanding and exploiting an emerging small molecule carbohydrate paradigm
Spraying for Yield
IWYP Call 2: Transforming yield through source-sink synchronisation
Delivering Sustainable Wheat
Designing Future Wheat (DFW) [ISPG]
Green Engineering
Publisher's version
Output statusPublished
Publication dates
Online29 Apr 2025
Publication process dates
Accepted21 Feb 2025
PublisherNature Publishing Group
ISSN1087-0156

Permalink - https://repository.rothamsted.ac.uk/item/99394/membrane-permeable-trehalose-6-phosphate-precursor-spray-increases-wheat-yields-in-field-trials

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