A - Papers appearing in refereed journals
Griffiths, C. A., Xue, X., Miret-Barrio, J., Salvagiotti, F., Acevedo-Siaca, L. G., Gimeno, J., Reynolds, M. P., Hassall, K., Halsey, K., Puranik, S., Oszvald, M., Kurup, S., Davis, B. G. and Paul, M. J. 2025. Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials. Nature Biotechnology. https://doi.org/10.1038/s41587-025-02611-1
Authors | Griffiths, C. A., Xue, X., Miret-Barrio, J., Salvagiotti, F., Acevedo-Siaca, L. G., Gimeno, J., Reynolds, M. P., Hassall, K., Halsey, K., Puranik, S., Oszvald, M., Kurup, S., Davis, B. G. and Paul, M. J. |
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Abstract | Trehalose 6-phosphate (T6P) is an endogenous sugar signal in plants that promotes growth, yet it cannot be introduced directly into crops or fully genetically controlled. Here we show that wheat yields were improved using a timed microdose of a plant-permeable, sunlight-activated T6P signaling precursor, DMNB-T6P, under a variety of agricultural conditions. Under both well-watered and water-stressed conditions over 4 years, DMNB-T6P stimulated yield of three elite varieties. Yield increases were an order of magnitude larger than average annual genetic gains of breeding programs and occurred without additional water or fertilizer. Mechanistic analyses reveal that these benefits arise from increased CO2 fixation and linear electron flow (‘source’) as well as from increased starchy endosperm volume, enhanced grain sieve tube development and upregulation of genes for starch, amino acid and protein synthesis (‘sink’). These data demonstrate a step-change, scalable technology with net benefit to the environment that could provide sustainable yield improvements of diverse staple cereal crops |
Keywords | Trehalose 6-phosphate; Wheat yields; Field trials; Source-sink |
Year of Publication | 2025 |
Journal | Nature Biotechnology |
Digital Object Identifier (DOI) | https://doi.org/10.1038/s41587-025-02611-1 |
Open access | Published as ‘gold’ (paid) open access |
Funder | UKRI-BBSRC |
Biotechnology and Biological Sciences Research Council | |
Engineering and Physical Sciences Research Council | |
Funder project or code | Trehalose signalling: understanding and exploiting an emerging small molecule carbohydrate paradigm |
Spraying for Yield | |
IWYP Call 2: Transforming yield through source-sink synchronisation | |
Delivering Sustainable Wheat | |
Designing Future Wheat (DFW) [ISPG] | |
Green Engineering | |
Publisher's version | |
Output status | Published |
Publication dates | |
Online | 29 Apr 2025 |
Publication process dates | |
Accepted | 21 Feb 2025 |
Publisher | Nature Publishing Group |
ISSN | 1087-0156 |
Permalink - https://repository.rothamsted.ac.uk/item/99394/membrane-permeable-trehalose-6-phosphate-precursor-spray-increases-wheat-yields-in-field-trials