PS: Lipid Metabolic Engineering and Synthetic Biology
| Title | PS: Lipid Metabolic Engineering and Synthetic Biology |
|---|---|
| Type | Research cluster |
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Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae
A - Papers appearing in refereed journals
Vaezi, R., Napier, J. A. and Sayanova, O. V. 2013. Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae. Marine Drugs. 11 (12), pp. 5116-5129. https://doi.org/10.3390/md11125116
Pan genome of the phytoplankton Emiliania underpins its global distribution
A - Papers appearing in refereed journals
Read, B. A., Kegel, J., Klute, M. J., Kuo, A., Lefebvre, S. C., Maumus, F., Mayer, C., Miller, J., Monier, A., Salamov, A., Young, J., Aguilar, M., Claverie, J-M., Frickenhaus, S., Gonzalez, K., Herman, E. K., Lin, Y-C. and Napier, J. A. 2013. Pan genome of the phytoplankton Emiliania underpins its global distribution. Nature. 499, pp. 209-213. https://doi.org/10.1038/nature12221
Oil production in the extreme
G - Articles in popular magazines and other technical publications
Haslam, R. P. and Michaelson, L. V. 2013. Oil production in the extreme. Annals of Applied Biology - AAB. 163 (2), pp. 170-173. https://doi.org/10.1111/aab.12058
Abnormal glycosphingolipid mannosylation triggers salicylic acid-mediated responses in Arabidopsis
A - Papers appearing in refereed journals
Mortimer, J. C., Yu, X., Albrecht, S., Sicilia, F., Huichalaf, M., Ampuero, D., Michaelson, L. V., Murphy, A. M., Matsunaga, T., Kurz, S., Stephens, E., Baldwin, T. C., Ishii, T., Napier, J. A., Weber, A. P. M., Handford, M. G. and Dupree, P. 2013. Abnormal glycosphingolipid mannosylation triggers salicylic acid-mediated responses in Arabidopsis. The Plant Cell. 25, pp. 1881-1894. https://doi.org/10.1105/tpc.113.111500
Plant sphingolipids: function follows form
A - Papers appearing in refereed journals
Markham, J. E., Lynch, D. V., Napier, J. A., Dunn, T. M. and Cahoon, E. B. 2013. Plant sphingolipids: function follows form. Current Opinion in Plant Biology. 16, pp. 350-357. https://doi.org/10.1016/j.pbi.2013.02.009
Involvement of Arabidopsis ACYL-COENZYME A DESATURASE-LIKE2 (At2g31360) in the biosynthesis of the very-long-chain monounsaturated fatty acid components of membrane lipids
A - Papers appearing in refereed journals
Smith, M. A., Dauk, M., Ramadan, H., Yang, H., Seamons, L. E., Haslam, R. P., Beaudoin, F., Ramirez-Erosa, I. and Forseille, L. 2013. Involvement of Arabidopsis ACYL-COENZYME A DESATURASE-LIKE2 (At2g31360) in the biosynthesis of the very-long-chain monounsaturated fatty acid components of membrane lipids. Plant Physiology. 161, pp. 81-96. https://doi.org/10.1104/pp.112.202325
Reconstitution of EPA and DHA biosynthesis in Arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants
A - Papers appearing in refereed journals
Ruiz-Lopez, N., Haslam, R. P., Usher, S. L., Napier, J. A. and Sayanova, O. V. 2013. Reconstitution of EPA and DHA biosynthesis in Arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants. Metabolic Engineering. 17, pp. 30-41. https://doi.org/10.1016/j.ymben.2013.03.001
The Arabidopsis cer26 mutant, like the cer2 mutant, is specifically affected in the very long chain fatty acid elongation process
A - Papers appearing in refereed journals
Pascal, S., Bernard, A., Sorel, M., Pervent, M., Vile, D., Haslam, R. P., Napier, J. A., Lessire, R., Domergue, F. and Joubes, J. 2013. The Arabidopsis cer26 mutant, like the cer2 mutant, is specifically affected in the very long chain fatty acid elongation process. The Plant Journal. 73 (5), pp. 733-746. https://doi.org/10.1111/tpj.12060
Identification of a cytochrome b5-fusion desaturase responsible for the synthesis of triunsaturated sphingolipid long chain bases in the marine diatom Thalassiosira pseudonana
A - Papers appearing in refereed journals
Michaelson, L. V., Markham, J. E., Zaeuner, S., Matsumoto, M., Chen, M., Cahoon, E. B. and Napier, J. A. 2013. Identification of a cytochrome b5-fusion desaturase responsible for the synthesis of triunsaturated sphingolipid long chain bases in the marine diatom Thalassiosira pseudonana. Phytochemistry. 90, pp. 50-55. https://doi.org/10.1016/j.phytochem.2013.02.010
The Arabidopsis F-box/Kelch-repeat protein At2g44130 is upregulated in giant cells and promotes nematode susceptibility
A - Papers appearing in refereed journals
Curtis, R. H. C., Pankaj, Powers, S. J., Napier, J. A. and Matthes, M. C. 2013. The Arabidopsis F-box/Kelch-repeat protein At2g44130 is upregulated in giant cells and promotes nematode susceptibility. Molecular Plant-Microbe Interactions - MPMI. 26, pp. 36-43. https://doi.org/10.1094/MPMI-05-12-0135-FI
The modification of plant oil composition via metabolic engineering - better nutrition by design
A - Papers appearing in refereed journals
Haslam, R. P., Ruiz-Lopez, N., Eastmond, P. J., Moloney, M., Sayanova, O. V. and Napier, J. A. 2013. The modification of plant oil composition via metabolic engineering - better nutrition by design. Plant Biotechnology Journal. 11 (2), pp. 157-168. https://doi.org/10.1111/pbi.12012
Delta 6 Desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 8329993 B2)
H1 - Patents granted
Napier, J. A. and Sayanova, O. V. 2012. Delta 6 Desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 8329993 B2). US 8329993 B2
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8273958 B2)
H1 - Patents granted
Napier, J. A. and Sayanova, O. V. 2012. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8273958 B2) . US 8273958 B2
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8258371 B2)
H1 - Patents granted
Napier, J. A. and Sayanova, O. V. 2012. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8258371 B2) . US 8258371 B2
Semiochemical (Patent US 8221736 B2)
H1 - Patents granted
Hick, J. A., Pickett, J. A., Wadhams, L. J. and Napier, J. A. 2012. Semiochemical (Patent US 8221736 B2). US 8221736 B2
Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent EP 2454278 A1)
H2 - Patents applied for
Bauer, J., Napier, J. A. and Sayanova, O. V. 2012. Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent EP 2454278 A1). EP 2454278 A1
Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 2012/0124705 A1)
H2 - Patents applied for
Napier, J. A., Bauer , J. and Sayanova, O. V. 2012. Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 2012/0124705 A1). US 2012/0124705 A1
Novel Fatty Acid Elongation Components And Uses Thereof (Patent US 2012/0084889 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V. and Beaudoin, F. 2012. Novel Fatty Acid Elongation Components And Uses Thereof (Patent US 2012/0084889 A1) . US 2012/0084889 A1
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent EP 1937805 B1)
H1 - Patents granted
Napier, J. A. and Sayanova, O. V. 2012. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent EP 1937805 B1). EP 1937805 B1
Elongase And Uses Thereof (Patent US 8119861 B2)
H1 - Patents granted
Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2012. Elongase And Uses Thereof (Patent US 8119861 B2) . US 8119861 B2
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2012/0017332 A1)
H2 - Patents applied for
Napier, J. A. and Sayanova, O. V. 2012. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2012/0017332 A1) . US 2012/0017332 A1
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2012/0011618 A1)
H2 - Patents applied for
Napier, J. A. and Sayanova, O. V. 2012. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2012/0011618 A1) . US 2012/0011618 A1
Draft genome sequence of the Coccolithovirus Emiliania huxleyi virus 202
A - Papers appearing in refereed journals
Nissimov, J. I., Worthy, C. A., Rooks, P., Napier, J. A., Kimmance, S. A., Henn, M. R., Ogata, H. and Allen, M. J. 2012. Draft genome sequence of the Coccolithovirus Emiliania huxleyi virus 202. Journal of Virology. 86 (4), pp. 2380-2381. https://doi.org/10.1128/jvi.06863-11
Draft genome sequence of four Coccolithoviruses: Emiliania huxleyi Virus EhV-88, EhV-201, EhV-207, and EhV-208
A - Papers appearing in refereed journals
Nissimov, J. I., Worthy, C. A., Rooks, P., Napier, J. A., Kimmance, S. A., Henn, M. R., Ogata, H. and Allen, M. J. 2012. Draft genome sequence of four Coccolithoviruses: Emiliania huxleyi Virus EhV-88, EhV-201, EhV-207, and EhV-208. Journal of Virology. 86 (5), pp. 2896-2897. https://doi.org/10.1128/jvi.07046-11
Metabolic engineering of plant-derived (E)-beta-farnesene synthase genes for a novel type of aphid-resistant genetically modified crop plants
A - Papers appearing in refereed journals
Yu, X-D., Pickett, J. A., Ma, Y-Z., Bruce, T. J. A., Napier, J. A., Jones, H. D. and Xia, L-Q. 2012. Metabolic engineering of plant-derived (E)-beta-farnesene synthase genes for a novel type of aphid-resistant genetically modified crop plants. Journal of Integrative Plant Biology. 54 (5), pp. 282-299. https://doi.org/10.1111/j.1744-7909.2012.01107.x
Metabolic engineering of the omega-3 long chain polyunsaturated fatty acid biosynthetic pathway into transgenic plants
A - Papers appearing in refereed journals
Ruiz-Lopez, N., Sayanova, O. V., Napier, J. A. and Haslam, R. P. 2012. Metabolic engineering of the omega-3 long chain polyunsaturated fatty acid biosynthetic pathway into transgenic plants. Journal of Experimental Botany. 63, pp. 2397-2410. https://doi.org/10.1093/jxb/err454
Enhancing the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Arabidopsis thaliana via iterative metabolic engineering and genetic crossing
A - Papers appearing in refereed journals
Ruiz-Lopez, N., Haslam, R. P., Venegas-Caleron, M., Li, T., Bauer, J., Napier, J. A. and Sayanova, O. V. 2012. Enhancing the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Arabidopsis thaliana via iterative metabolic engineering and genetic crossing. Transgenic Research. 21, pp. 1233-1243. https://doi.org/10.1007/s11248-012-9596-0
Reconstitution of plant alkane biosynthesis in yeast demonstrates that Arabidopsis ECERIFERUM1 and ECERIFERUM3 are core components of a very-long-chain alkane synthesis complex
A - Papers appearing in refereed journals
Bernard, A., Domergue, F., Pascal, S., Jetter, R., Renne, C., Faure, J-D., Haslam, R. P., Napier, J. A., Lessire, R. and Joubes, J. 2012. Reconstitution of plant alkane biosynthesis in yeast demonstrates that Arabidopsis ECERIFERUM1 and ECERIFERUM3 are core components of a very-long-chain alkane synthesis complex. The Plant Cell. 24, pp. 3106-3118. https://doi.org/10.1105/tpc.112.099796
Feedback regulation of plastidic acetyl-CoA carboxylase by 18:1-acyl carrier protein in Brassica napus
A - Papers appearing in refereed journals
Andre, C., Haslam, R. P. and Shanklin, J. 2012. Feedback regulation of plastidic acetyl-CoA carboxylase by 18:1-acyl carrier protein in Brassica napus. Proceedings of the National Academy of Sciences. 109, pp. 10107-10112. https://doi.org/10.1073/pnas.1204604109
The role of delta6-desaturase acyl-carrier specificity in the efficient synthesis of long-chain polyunsaturated fatty acids in transgenic plants
A - Papers appearing in refereed journals
Sayanova, O. V., Ruiz-Lopez, N., Haslam, R. P. and Napier, J. A. 2012. The role of delta6-desaturase acyl-carrier specificity in the efficient synthesis of long-chain polyunsaturated fatty acids in transgenic plants. Plant Biotechnology Journal. 10 (2), pp. 195-206. https://doi.org/10.1111/j.1467-7652.2011.00653.x
Acyltransferases And Uses Therof In Fatty Acid Production (Patent CA 2804925 A1)
H2 - Patents applied for
Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2011. Acyltransferases And Uses Therof In Fatty Acid Production (Patent CA 2804925 A1) . CA 2804925 A1
Acyltransferases And Uses Therof In Fatty Acid Production (Patent WO 2011/161093 A1)
H2 - Patents applied for
Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2011. Acyltransferases And Uses Therof In Fatty Acid Production (Patent WO 2011/161093 A1). WO 2011/161093 A1
Process For The Production Of Delta5-unsaturated Fatty Acids In Transgenic Organisms (Patent EP 2388332 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V. and Zank, T. 2011. Process For The Production Of Delta5-unsaturated Fatty Acids In Transgenic Organisms (Patent EP 2388332 A1) . EP 2388332 A1
Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 2011/0277043 A1)
H2 - Patents applied for
Bauer, J., Senger, T. and Napier, J. A. 2011. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 2011/0277043 A1) . US 2011/0277043 A1
Process For Producing A Polyunsatured Fatty Acid Comprising Arachidonic Acid (Patent EP 2380984 A2)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2011. Process For Producing A Polyunsatured Fatty Acid Comprising Arachidonic Acid (Patent EP 2380984 A2) . EP 2380984 A2
Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2376638 A2)
H2 - Patents applied for
Napier, J. A., Senger, T. and Bauer, J. 2011. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2376638 A2). EP 2376638 A2
Process For The Production Of Delta5-unsaturated Fatty Acids In Transgenic Organisms (Patent EP 2366781 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V. and Zank, T. 2011. Process For The Production Of Delta5-unsaturated Fatty Acids In Transgenic Organisms (Patent EP 2366781 A1) . EP 2366781 A1
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8017839 B2)
H1 - Patents granted
Napier, J. A. and Sayanova, O. V. 2011. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8017839 B2) . US 8017839 B2
Method For The Production Of Γ-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent US 8013216 B2 )
H1 - Patents granted
Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2011. Method For The Production Of Γ-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent US 8013216 B2 ). US 8013216 B2
Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1726652 B1)
H1 - Patents granted
Napier, J. A. and Sayanova, O. V. 2011. Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1726652 B1). EP 1726652 B1