A stable start - cotranslational Nt-acetylation promotes proteome stability across kingdoms

A - Papers appearing in refereed journals

Gibbs, D. J., Bailey, M. and Etherington, R. D. 2022. A stable start - cotranslational Nt-acetylation promotes proteome stability across kingdoms. Trends in Cell Biology. 32 (5), pp. 374-376. https://doi.org/10.1016/j.tcb.2022.02.004

AuthorsGibbs, D. J., Bailey, M. and Etherington, R. D.
Abstract

Two recent studies show that cotranslational N-terminal protein acetylation (NTA) promotes proteome stability in humans (Mueller et al.) and plants (Linster et al.) by
masking nonacetylated N-degrons that would otherwise destabilise proteins. This is in contrast to previous findings linking NTA to degradation, suggesting that this
widespread mark has complex and context-specific functions in
regulating protein half-lives

KeywordsAcetylation ; N-degron pathway; Proteostasis; N terminus; Cotranslational modification; Proteolysis
Year of Publication2022
JournalTrends in Cell Biology
Journal citation32 (5), pp. 374-376
Digital Object Identifier (DOI)https://doi.org/10.1016/j.tcb.2022.02.004
Open accessPublished as non-open access
FunderBiotechnology and Biological Sciences Research Council
European Research Council
Funder project or codeTPM - Tailoring Plant Metabolism - Work package 1 (WP1) - High value lipids for health and industry
BB/V008587/1
ERC-StG 715441-GasPlaNt
Output statusPublished
Publication dates
Online05 Mar 2022

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