Characterisation and partial purification of acyl-CoA:glycerol 3-phosphate acyltransferase from sunflower Helianthus annuus L.) developing seeds

Ruiz-Lopez, N., Garces, R., Harwood, J. L. and Martinez-Force, E. 2010. Characterisation and partial purification of acyl-CoA:glycerol 3-phosphate acyltransferase from sunflower Helianthus annuus L.) developing seeds. Plant Physiology and Biochemistry. 48, pp. 73-80. https://doi.org/10.1016/j.plaphy.2009.12.001

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Acyltransferases And Uses Therof In Fatty Acid Production (Patent EP 2585603 B1)

H1 - Patents granted

Senger, T., Marty, L., Stymne, S., Lindberg , Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2017. Acyltransferases And Uses Therof In Fatty Acid Production (Patent EP 2585603 B1). EP 2585603 B1

Tailoring the composition of novel wax esters in the seeds of transgenic Camelina sativa through systematic metabolic engineering

A - Papers appearing in refereed journals

Ruiz-Lopez, N., Broughton, R., Usher, S. L., Salas, J. J., Haslam, R. P., Napier, J. A. and Beaudoin, F. 2017. Tailoring the composition of novel wax esters in the seeds of transgenic Camelina sativa through systematic metabolic engineering. Plant Biotechnology Journal. 15 (7), pp. 837-849. https://doi.org/10.1111/pbi.12679

Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2016/0272951 A1)

H2 - Patents applied for

Senger, T., Marty, L., Stymne S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2016. Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2016/0272951 A1) . US 2016/0272951 A1

Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 9388437 B2)

H1 - Patents granted

Napier, J. A., Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2016. Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 9388437 B2) . US 9388437 B2 182-807-288-915-40X

A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice

A - Papers appearing in refereed journals

Tejera, N., Vauzour, D., Betancor, M. B., Sayanova, O. V., Usher, S., Cochard, M., Rigby, N., Ruiz-Lopez, N., Menoyo, D., Tocher, D. R., Napier, J. A. and Minihane, A. M. 2016. A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice. Journal Of Nutrition. 146 (2), pp. 227-235. https://doi.org/10.3945/jn.115.223941

Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent US 2015/0216828 A1)

H2 - Patents applied for

Napier, J. A., Sayanova, O. V., Ruiz-Lopez, N. and Haslam, R. P. 2015. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent US 2015/0216828 A1) . US 2015/0216828 A1

Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent EP 2836599 A1)

H2 - Patents applied for

Napier, J. A., Ruiz-Lopez, N. and Haslam, R. P. 2015. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent EP 2836599 A1) . EP 2836599 A1

Field trial evaluation of the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Camelina sativa: making fish oil substitutes in plants

A - Papers appearing in refereed journals

Usher, S. L., Haslam, R. P., Ruiz-Lopez, N., Sayanova, O. V. and Napier, J. A. 2015. Field trial evaluation of the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Camelina sativa: making fish oil substitutes in plants. Metabolic Engineering Communications. 2, pp. 93-98. https://doi.org/10.1016/j.meteno.2015.04.002

Transgenic plants as a sustainable, terrestrial source of fish oils

A - Papers appearing in refereed journals

Napier, J. A., Usher, S. L., Haslam, R. P., Ruiz-Lopez, N. and Sayanova, O. V. 2015. Transgenic plants as a sustainable, terrestrial source of fish oils. European Journal Of Lipid Science And Technology. 117 (9), pp. 1317-1324. https://doi.org/10.1002/ejlt.201400452

An alternative pathway for the effective production of the omega-3 long-chain polyunsaturates EPA and ETA in transgenic oilseeds

A - Papers appearing in refereed journals

Ruiz-Lopez, N., Haslam, R. P., Usher, S. L., Napier, J. A. and Sayanova, O. V. 2015. An alternative pathway for the effective production of the omega-3 long-chain polyunsaturates EPA and ETA in transgenic oilseeds. Plant Biotechnology Journal. 13 (9), pp. 1264-1275. https://doi.org/10.1111/pbi.12328

Modifying the lipid content and composition of plant seeds: engineering the production of LC-PUFA

A - Papers appearing in refereed journals

Ruiz-Lopez, N., Usher, S. L., Sayanova, O. V., Napier, J. A. and Haslam, R. P. 2015. Modifying the lipid content and composition of plant seeds: engineering the production of LC-PUFA. Applied Microbiology and Biotechnology. 99 (1), pp. 143-154. https://doi.org/10.1007/s00253-014-6217-2

Metabolic engineering of biomass for high energy density: oilseed-like triacylglycerol yields from plant leaves

A - Papers appearing in refereed journals

Vanhercke, T., El Tahchy, A., Liu, Q., Zhou, X-R., Shrestha, P., Divi, U. K., Ral, J-P., Mansour, M. P., Nichols, P. D., James, C. N., Horn, P. J., Chapman, K. D., Beaudoin, F., Ruiz-Lopez, N., Larkin, P. J., De Feyter, R. C., Singh, S. P. and Petrie, J. R. 2014. Metabolic engineering of biomass for high energy density: oilseed-like triacylglycerol yields from plant leaves. Plant Biotechnology Journal. 12 (2), pp. 231-239. https://doi.org/10.1111/pbi.12131

Successful high-level accumulation of fish oil omega-3 long-chain polyunsaturated fatty acids in a transgenic oilseed crop

A - Papers appearing in refereed journals

Ruiz-Lopez, N., Haslam, R. P., Napier, J. A. and Sayanova, O. V. 2014. Successful high-level accumulation of fish oil omega-3 long-chain polyunsaturated fatty acids in a transgenic oilseed crop. The Plant Journal. 77 (2), pp. 198-208. https://doi.org/10.1111/tpj.12378

Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent CA 2869738 A1)

H2 - Patents applied for

Napier, J. A., Sayanova, O. V., Ruiz-Lopez, N. and Haslam, R. P. 2013. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent CA 2869738 A1). CA 2869738 A1

Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent WO 2013/153404 A1)

H2 - Patents applied for

Napier, J. A., Sayanova, O. V., Ruiz-Lopez, N. and Haslam, R. P. 2013. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent WO 2013/153404 A1) . WO 2013/153404 A1

Acyltransferases And Uses Therof In Fatty Acid Production (Patent EP 2585603 A1)

H2 - Patents applied for

Senger Toralf, Marty, L., Stymne, S., Lindberg Yilmaz Jenny, Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2013. Acyltransferases And Uses Therof In Fatty Acid Production (Patent EP 2585603 A1) . EP 2585603 A1

Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2013/0097733 A1)

H2 - Patents applied for

Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2013. Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2013/0097733 A1) . US 2013/0097733 A1

Reconstitution of EPA and DHA biosynthesis in Arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants

A - Papers appearing in refereed journals

Ruiz-Lopez, N., Haslam, R. P., Usher, S. L., Napier, J. A. and Sayanova, O. V. 2013. Reconstitution of EPA and DHA biosynthesis in Arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants. Metabolic Engineering. 17, pp. 30-41. https://doi.org/10.1016/j.ymben.2013.03.001

The modification of plant oil composition via metabolic engineering - better nutrition by design

A - Papers appearing in refereed journals

Haslam, R. P., Ruiz-Lopez, N., Eastmond, P. J., Moloney, M., Sayanova, O. V. and Napier, J. A. 2013. The modification of plant oil composition via metabolic engineering - better nutrition by design. Plant Biotechnology Journal. 11 (2), pp. 157-168. https://doi.org/10.1111/pbi.12012

Metabolic engineering of the omega-3 long chain polyunsaturated fatty acid biosynthetic pathway into transgenic plants

A - Papers appearing in refereed journals

Ruiz-Lopez, N., Sayanova, O. V., Napier, J. A. and Haslam, R. P. 2012. Metabolic engineering of the omega-3 long chain polyunsaturated fatty acid biosynthetic pathway into transgenic plants. Journal of Experimental Botany. 63, pp. 2397-2410. https://doi.org/10.1093/jxb/err454

Enhancing the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Arabidopsis thaliana via iterative metabolic engineering and genetic crossing

A - Papers appearing in refereed journals

Ruiz-Lopez, N., Haslam, R. P., Venegas-Caleron, M., Li, T., Bauer, J., Napier, J. A. and Sayanova, O. V. 2012. Enhancing the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Arabidopsis thaliana via iterative metabolic engineering and genetic crossing. Transgenic Research. 21, pp. 1233-1243. https://doi.org/10.1007/s11248-012-9596-0

The role of delta6-desaturase acyl-carrier specificity in the efficient synthesis of long-chain polyunsaturated fatty acids in transgenic plants

A - Papers appearing in refereed journals

Sayanova, O. V., Ruiz-Lopez, N., Haslam, R. P. and Napier, J. A. 2012. The role of delta6-desaturase acyl-carrier specificity in the efficient synthesis of long-chain polyunsaturated fatty acids in transgenic plants. Plant Biotechnology Journal. 10 (2), pp. 195-206. https://doi.org/10.1111/j.1467-7652.2011.00653.x

Acyltransferases And Uses Therof In Fatty Acid Production (Patent CA 2804925 A1)

H2 - Patents applied for

Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2011. Acyltransferases And Uses Therof In Fatty Acid Production (Patent CA 2804925 A1) . CA 2804925 A1

Acyltransferases And Uses Therof In Fatty Acid Production (Patent WO 2011/161093 A1)

H2 - Patents applied for

Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2011. Acyltransferases And Uses Therof In Fatty Acid Production (Patent WO 2011/161093 A1). WO 2011/161093 A1

Identification and functional characterisation of genes encoding the omega-3 polyunsaturated fatty acid biosynthetic pathway from the coccolithophore Emiliania huxleyi

A - Papers appearing in refereed journals

Sayanova, O. V., Haslam, R. P., Venegas Caleron, M., Ruiz-Lopez, N., Worthy, C., Rooks, P., Allen, M. J. and Napier, J. A. 2011. Identification and functional characterisation of genes encoding the omega-3 polyunsaturated fatty acid biosynthetic pathway from the coccolithophore Emiliania huxleyi. Phytochemistry. 72, pp. 594-600. https://doi.org/10.1016/j.phytochem.2011.01.022

The production of Omega-3 Very Long-Chain Polyunsaturated Fatty Acids in transgenic plants: a sustainable source of omega-3 fish oils

C2 - Non-edited contributions to conferences

Ruiz-Lopez, N., Haslam, R. P., Sayanova, O. V. and Napier, J. A. 2010. The production of Omega-3 Very Long-Chain Polyunsaturated Fatty Acids in transgenic plants: a sustainable source of omega-3 fish oils.  Abstracts from the 51st International Conference on the Bioscience of Lipids. https://doi.org/10.1016/j.chemphyslip.2010.05.055

The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of 'heart-healthy' omega-3 fatty acids

A - Papers appearing in refereed journals

Ruiz-Lopez, N., Haslam, R. P., Venegas-Caleron, M., Larson, T. R., Graham, I. A., Napier, J. A. and Sayanova, O. V. 2009. The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of 'heart-healthy' omega-3 fatty acids. Plant Biotechnology Journal. 7 (7), pp. 704-716. https://doi.org/10.1111/j.1467-7652.2009.00436.x

cDNA cloning, expression levels and gene mapping of photosynthetic and non-photosynthetic ferredoxin genes in sunflower (Helianthus annuus L.)

A - Papers appearing in refereed journals

Venegas-Caleron, M., Zambelli, A., Ruiz-Lopez, N., Youssar, L., Leon, A., Garces, R. and Martinez-Force, E. 2009. cDNA cloning, expression levels and gene mapping of photosynthetic and non-photosynthetic ferredoxin genes in sunflower (Helianthus annuus L.). Theoretical and Applied Genetics. 118, pp. 891-901. https://doi.org/10.1007/s00122-008-0947-4