A Two-Step Process for Converting Methane to Canthaxanthin Using Methylococcus capsulatus (Bath) Biomass and Engineered Yarrowia lipolytica
A - Papers appearing in refereed journals
Taratynova, M. O., Tarasov, I. M., Fedyaeva, I. M., Dementev, D. A., Gorchakova, V. A., Tarasova, M. A., Fedorov, A. S., Yuzbashev, T., Sineoky, S. P. and Yuzbasheva, E. Y. 2025. A Two-Step Process for Converting Methane to Canthaxanthin Using Methylococcus capsulatus (Bath) Biomass and Engineered Yarrowia lipolytica. Biotechnology Journal. 20 (6), p. e70043. https://doi.org/10.1002/biot.70043
| Authors | Taratynova, M. O., Tarasov, I. M., Fedyaeva, I. M., Dementev, D. A., Gorchakova, V. A., Tarasova, M. A., Fedorov, A. S., Yuzbashev, T., Sineoky, S. P. and Yuzbasheva, E. Y. |
|---|---|
| Abstract | Methane biotransformation is gaining attention for the bio-industry and environmental protection. This study presents an approach for converting methane to canthaxanthin using Methylococcus capsulatus biomass and Yarrowia lipolytica. Y. lipolytica was engineered to introduce the canthaxanthin biosynthesis pathway, increase the acetyl-CoA flux, and boost hexose catabolism. In methanotroph-derived medium with molasses, canthaxanthin titer reached 1.2 g/L, advancing cost-effective, sustainable bioproduction. |
| Keywords | Canthaxanthin ; Methane; Methanotroph protein hydrolysate; Molasses ; Yarrowia lipolytica |
| Year of Publication | 2025 |
| Journal | Biotechnology Journal |
| Journal citation | 20 (6), p. e70043 |
| Digital Object Identifier (DOI) | https://doi.org/10.1002/biot.70043 |
| Open access | Published as non-open access |
| Output status | Published |
| Publication dates | |
| Online | 09 Jun 2025 |
| Publication process dates | |
| Accepted | 07 May 2025 |
| Publisher | Wiley |
| ISSN | 1860-6768 |
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