Cleavage of acyl-CoA by peroxisomal ABC subfamily D transporters in peroxisomes: mechanism and functional roles

Project (past)

Project dates17 Feb 2014 to end of 16 Dec 2017
Researchers
Principal InvestigatorFreddie Theodoulou
FunderBiotechnology and Biological Sciences Research Council
Project numberS5313
5313
DepartmentBiological Chemistry and Crop Protection (BCCP)
Research fish codeBB/L001691/1
Grant IDBB/L001691/1

Outputs

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The Saccharomyces cerevisiae ABCD subfamily transporter Pxa1/Pxa2p co-imports CoASH into the peroxisome

A - Papers appearing in refereed journals
Van Roermund, C. W. T., IJlst, L., Baker, A., Wanders, R. J. A., Theodoulou, F. L. and Waterham, H. R. 2020. The Saccharomyces cerevisiae ABCD subfamily transporter Pxa1/Pxa2p co-imports CoASH into the peroxisome. FEBS Letters. https://doi.org/10.1002/1873-3468.13974

Mutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose

A - Papers appearing in refereed journals
Carrier, D., van Roermund, C., Schaedler, T. A., Rong, H., Ijlist, L., Wanders, r., Baldwin, S., Waterham, H., Theodoulou, F. L. and Baker, A. 2019. Mutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose. Scientific Reports. 9. https://doi.org/10.1038/s41598-019-46685-9

How to move an amphipathic molecule across a lipid bilayer: different mechanisms for different ABC transporters?

A - Papers appearing in refereed journals
Theodoulou, F. L., Carrier, D. J., Schaedler, T. A., Baldwin, S. A. and Baker, A. 2016. How to move an amphipathic molecule across a lipid bilayer: different mechanisms for different ABC transporters? Biochemical Society Transactions. 44 (3), pp. 774-782. https://doi.org/10.1042/BST20160040

ABC transporter research: going strong 40 years on

A - Papers appearing in refereed journals
Theodoulou, F. L. and Kerr, I. D. 2015. ABC transporter research: going strong 40 years on. Biochemical Society Transactions. 43 (5), pp. 1033-1040. https://doi.org/10.1042/BST20150139

Peroxisomal ABC transporters: functions and mechanisms

A - Papers appearing in refereed journals
Baker, A., Carrier, D. J., Schaedler, T. A., Waterham, H. R., Van Roermund, C. W. and Theodoulou, F. L. 2015. Peroxisomal ABC transporters: functions and mechanisms. Biochemical Society Transactions. 43, pp. 959-965. https://doi.org/10.1042/BST20150127

Plant peroxisomal ABC transporters: flexible and unusual

B - Book chapters etc edited externally
Theodoulou, F. L., Baldwin, S. A., Baldwin, J. M. and Baker, A. 2014. Plant peroxisomal ABC transporters: flexible and unusual. in: Geisler, M. (ed.) Plant ABC transporters Springer. pp. 77-101