Plant peroxisomal ABC transporters: flexible and unusual

B - Book chapters etc edited externally

Theodoulou, F. L., Baldwin, S. A., Baldwin, J. M. and Baker, A. 2014. Plant peroxisomal ABC transporters: flexible and unusual. in: Geisler, M. (ed.) Plant ABC transporters Springer. pp. 77-101

AuthorsTheodoulou, F. L., Baldwin, S. A., Baldwin, J. M. and Baker, A.
EditorsGeisler, M.
Abstract

ABC transporters of subfamily D mediate import of substrates for β-oxidation into peroxisomes. Whilst mammals possess three peroxisomal ABCD proteins which homodimerise to form transporters with distinct substrate specificities, Baker’s yeast has a single transporter formed by heterodimerisation, which imports long-chain fatty acyl CoAs. Plants have a single-fused heterodimer transporter that exhibits broad substrate specificity, reflecting the wide range of β-oxidation substrates processed by plants. The fusion appears to have occurred early in the evolution of land plants and was followed by an early duplication event in the monocot lineage. Plant ABCD proteins function in all stages of the life cycle and their physiological roles reflect the ability to transport diverse substrates including saturated and unsaturated fatty acids and aromatic compounds such as precursors of hormones and secondary metabolites. Recent work suggests that transport of CoA substrates involves their cleavage and re-esterification within the peroxisome, thus interaction with appropriate acyl adenylate-activating enzymes potentially provides a mechanism for regulating entry of different substrates into β-oxidation. The mechanism of ABCD transporter targeting is broadly conserved across kingdoms but evidence suggests the regulation of protein turnover differs.

Page range77-101
Year of Publication2014
Book titlePlant ABC transporters
PublisherSpringer
SeriesSignalling and Communication in Plants (SIGCOMM, Vol.22)
ISBN9783319065113
Digital Object Identifier (DOI)doi:10.1007/978-3-319-06511-3_6
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeDesigning Seeds for Nutrition and Health (DS)
Cleavage of acyl-CoA by peroxisomal ABC subfamily D transporters in peroxisomes: mechanism and functional roles
*Design Oilseeds (Freddie Theodoulou)
Open accessPublished as non-open access
Output statusPublished
Publication dates
Online18 Jun 2004
Copyright licensePublisher copyright

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