Mammalian peroxisomal ABC transporters: from endogenous substrates to pathology and clinical significance

A - Papers appearing in refereed journals

Kemp, S., Theodoulou, F. L. and Wanders, R. J. A. 2011. Mammalian peroxisomal ABC transporters: from endogenous substrates to pathology and clinical significance. British Journal Of Pharmacology. 164 (7), pp. 1753-1766.

AuthorsKemp, S., Theodoulou, F. L. and Wanders, R. J. A.
Abstract

Peroxisomes are indispensable organelles in higher eukaryotes. They are essential for a number of important metabolic pathways, including fatty acid a- and beta-oxidation, and biosynthesis of etherphospholipids and bile acids. However, the peroxisomal membrane forms an impermeable barrier to these metabolites. Therefore, peroxisomes need specific transporter proteins to transfer these metabolites across their membranes. The mammalian peroxisomal membrane harbours three ATP-binding cassette (ABC) transporters. In recent years, significant progress has been made in unravelling the functions of these ABC transporters. There is ample evidence that they are involved in the transport of very long-chain fatty acids, pristanic acid, di- and trihydroxycholestanoic acid, dicarboxylic acids and tetracosahexaenoic acid (C24:6?3). Surprisingly, only one disease is associated with a deficiency of a peroxisomal ABC transporter. Mutations in the ABCD1 gene encoding the peroxisomal ABC transporter adrenoleukodystrophy protein are the cause for X-linked adrenoleukodystrophy, an inherited metabolic storage disorder. This review describes the current state of knowledge on the mammalian peroxisomal ABC transporters with a particular focus on their function in metabolite transport.

KeywordsPharmacology & Pharmacy
Year of Publication2011
JournalBritish Journal Of Pharmacology
Journal citation164 (7), pp. 1753-1766
Digital Object Identifier (DOI)doi:10.1111/j.1476-5381.2011.01435.x
PubMed ID21488864
Open accessPublished as non-open access
FunderBiotechnology and Biological Sciences Research Council
Netherlands Organization for Scientific Research ( NWO)
European Leukodystrophy Association [ELA]
Prinses Beatrix Fonds
Funder project or codeCentre for Crop Genetic Improvement (CGI)
Lipid transport and metabolism
Purification and functional characterisation of COMATOSE a peroxisomal ABC transporter from Arabidopsis thaliana
ISSN00071188
0007-1188
PublisherWiley
Grant IDBB/F007299/1
2008-05111A
WAR08-20
91786328

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