PS: Lipid Metabolic Engineering and Synthetic Biology

TitlePS: Lipid Metabolic Engineering and Synthetic Biology
TypeResearch cluster

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Recombinant Cells And Plants For Synthesis Of Very Long Chains Fatty Acid (vlcfa) (Patent US 2011/0189697 A1)

H2 - Patents applied for
Faure, J-D., Bach, L., Miquel, M. and Napier, J. A. 2011. Recombinant Cells And Plants For Synthesis Of Very Long Chains Fatty Acid (vlcfa) (Patent US 2011/0189697 A1) . US 2011/0189697 A1

Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 2011/0138490 A1)

H2 - Patents applied for
Bauer, J., Napier, J. A. and Sayanova, O. V. 2011. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 2011/0138490 A1) . US 2011/0138490 A1

Nucleic Acid (Patent EP 1984502 B1)

H1 - Patents granted
Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2011. Nucleic Acid (Patent EP 1984502 B1). EP 1984502 B1

Recombinant Cells And Plants For Synthesis Of Very Long Chains Fatty Acid (vlcfa) (Patent EP 2310512 A1)

H2 - Patents applied for
Faure, J-D., Bach, L., Miquel, M. and Napier, J. A. 2011. Recombinant Cells And Plants For Synthesis Of Very Long Chains Fatty Acid (vlcfa) (Patent EP 2310512 A1) . EP 2310512 A1

Method For The Production Of Gamma-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent EP 1945775 B1)

H1 - Patents granted
Napier, J. A., Sayanova, O. V. and Vengas, C. M. 2011. Method For The Production Of Gamma-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent EP 1945775 B1) . EP 1945775 B1

Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2281051 A1)

H2 - Patents applied for
Bauer, J., Napier, J. A. and Sayanova, O. V. 2011. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2281051 A1) . EP 2281051 A1

Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent CA 2768082 A1)

H2 - Patents applied for
Bauer, J., Napier, J. A. and Sayanova, O. V. 2011. Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent CA 2768082 A1) . CA 2768082 A1

Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent WO 2011/006948 A1)

H2 - Patents applied for
Bauer, J., Napier, J. A. and Sayanova, O. V. 2011. Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent WO 2011/006948 A1). WO 2011/006948 A1

Transgenic wheat emitting aphid alarm pheromone, (E)-beta-farnesene

C1 - Edited contributions to conferences/learned societies
Bruce, T. J. A., Smart, L. E., Martin, J. L., Doherty, A., Jones, H. D., Napier, J. A. and Pickett, J. A. 2011. Transgenic wheat emitting aphid alarm pheromone, (E)-beta-farnesene. GM Crops: from Basic Research to Application. Aspects of Applied Biology 110 . Association of Applied Biologists (AAB) Wellesbourne Warwick . pp. 24

Transgenic wheat emitting aphid alarm pheromone, (E)-beta-farnesene

C1 - Edited contributions to conferences/learned societies
Bruce, T. J. A., Smart, L. E., Aradottir, G. I., Martin, J. L., Doherty, A., Jones, H. D., Napier, J. A. and Pickett, J. A. 2011. Transgenic wheat emitting aphid alarm pheromone, (E)-beta-farnesene. GM Crops: from Basic Research to Application. Aspects of Applied Biology 110 . Association of Applied Biologists (AAB) Wellesbourne Warwick . pp. 112

Transgenic wheat emitting aphid alarm pheromone, (E)-beta-farnesene

C2 - Non-edited contributions to conferences
Bruce, T. J. A., Smart, L. E., Aradottir, G. I., Martin, J. L., Doherty, A., Jones, H. D., Napier, J. A. and Pickett, J. A. 2011. Transgenic wheat emitting aphid alarm pheromone, (E)-beta-farnesene. Abstracts Ento' 11 Symposium on Chemical Ecology: Reception, Detection and Deception, Chatham, 7-9 September 2011 . pp. 54

Draft genome sequence of the coccolithovirus EhV-84

A - Papers appearing in refereed journals
Nissimov, J. I., Worthy, C. A., Rooks, P., Napier, J. A., Kimmance, S. A., Henn, M. R., Ogata, H. and Allen, M. J. 2011. Draft genome sequence of the coccolithovirus EhV-84. Standards in Genomic Sciences. 5, pp. 1-11. https://doi.org/10.4056/sigs.1884581

Transgenic oilseed crops as an alternative to fish oils

A - Papers appearing in refereed journals
Sayanova, O. V. and Napier, J. A. 2011. Transgenic oilseed crops as an alternative to fish oils. Prostaglandins, Leukotrienes and Essential Fatty Acids. 85, pp. 253-260. https://doi.org/10.1016/j.plefa.2011.04.013

Draft genome sequence of the coccolithovirus Emiliania huxleyi virus 203

A - Papers appearing in refereed journals
Nissimov, J. I., Worthy, C. A., Rooks, P., Napier, J. A., Kimmance, S. A., Henn, M. R., Ogata, H. and Allen, M. J. 2011. Draft genome sequence of the coccolithovirus Emiliania huxleyi virus 203. Journal of Virology. 85 (24), pp. 13468-13469. https://doi.org/10.1128/JVI.06440-11

Targeted enhancement of glutamate-to-gamma-aminobutyrate conversion in Arabidopsis seeds affects carbon-nitrogen balance and storage reserves in a development-dependent manner

A - Papers appearing in refereed journals
Fait, A., Nunes Nesi, A., Angelovici, R., Lehmann, M., Anh Pham, P., Song, L., Haslam, R. P., Napier, J. A., Galili, G. and Fernie, A. R. 2011. Targeted enhancement of glutamate-to-gamma-aminobutyrate conversion in Arabidopsis seeds affects carbon-nitrogen balance and storage reserves in a development-dependent manner. Plant Physiology. 157, pp. 1026-1042. https://doi.org/10.1104/pp.111.179986

LC-MS/MS methods for absolute quantification and identification of proteins associated with chimeric plant oil bodies

A - Papers appearing in refereed journals
Capuano, F., Bond, N. J., Gatto, L., Beaudoin, F., Napier, J. A., Benvenuto, E., Lilley, K. S. and Baschieri, S. 2011. LC-MS/MS methods for absolute quantification and identification of proteins associated with chimeric plant oil bodies. Analytical Chemistry. 83, pp. 9267-9272. https://doi.org/10.1021/ac201733m

Very-long-chain fatty acids are required for cell plate formation during cytokinesis in Arabidopsis thaliana

A - Papers appearing in refereed journals
Bach, L., Gissot, L., Marion, J., Tellier, F., Moreau, P., Satiat-Jeunemaitre, B., Palauqui, J-C., Napier, J. A. and Faure, J-D. 2011. Very-long-chain fatty acids are required for cell plate formation during cytokinesis in Arabidopsis thaliana. Journal Of Cell Science. 124, pp. 3223-234. https://doi.org/10.1242/jcs.074575

Coccolithophores: functional biodiversity, enzymes and bioprospecting

A - Papers appearing in refereed journals
Reid, E. L., Worthy, C. A., Probert, I., Ali, S. T., Love, J., Napier, J. A., Littlechild, J. A., Somerfield, P. J. and Allen, M. J. 2011. Coccolithophores: functional biodiversity, enzymes and bioprospecting. Marine Drugs. 9 (4), pp. 586-602. https://doi.org/10.3390/md9040586

New insights into cell death induced by long chain bases in Arabidopsis

G - Articles in popular magazines and other technical publications
Michaelson, L. V. 2011. New insights into cell death induced by long chain bases in Arabidopsis. New Phytologist. 191 (4), pp. 909-911. https://doi.org/10.1111/j.1469-8137.2011.03843.x

Emerging roles in plant defense for cis- jasmone-induced cytochrome P450 CYP81D11

A - Papers appearing in refereed journals
Matthes, M. C., Bruce, T. J. A., Chamberlain, K., Pickett, J. A. and Napier, J. A. 2011. Emerging roles in plant defense for cis- jasmone-induced cytochrome P450 CYP81D11. Plant Signaling and Behavior. 6, pp. 563-565. https://doi.org/10.4161/psb.6.4.14915

New frontiers in oilseed biotechnology: meeting the global demand for vegetable oils for food, feed, biofuel and industrial applications

A - Papers appearing in refereed journals
Lu, C., Napier, J. A., Clemente, T. E. and Cahoon, E. B. 2011. New frontiers in oilseed biotechnology: meeting the global demand for vegetable oils for food, feed, biofuel and industrial applications. Current Opinion in Biotechnology. 22, pp. 252-259. https://doi.org/10.1016/j.copbio.2010.11.006

Overexpression of Arabidopsis ECERIFERUM1 promotes wax very-long-chain alkane biosynthesis and influences plant response to biotic and abiotic stresses

A - Papers appearing in refereed journals
Bourdenx, B., Bernard, A., Domergue, F., Pascal, S., Leger, A., Roby, D., Pervent, M., Vile, D., Haslam, R. P., Napier, J. A., Lessire, R. and Joubes, J. 2011. Overexpression of Arabidopsis ECERIFERUM1 promotes wax very-long-chain alkane biosynthesis and influences plant response to biotic and abiotic stresses. Plant Physiology. 156, pp. 29-45. https://doi.org/10.1104/pp.111.172320

Metabolic engineering of Saccharomyces cerevisiae for production of eicosapentaenoic acid, using a novel delta5-desaturase from Paramecium tetraurelia

A - Papers appearing in refereed journals
Tavares, S., Grotkjaer, T., Obsen, T., Haslam, R. P., Napier, J. A. and Gunnarsson, N. 2011. Metabolic engineering of Saccharomyces cerevisiae for production of eicosapentaenoic acid, using a novel delta5-desaturase from Paramecium tetraurelia. Applied and Environmental Microbiology. 77, pp. 1854-1861. https://doi.org/10.1128/AEM.01935-10

The identification and mapping of candidate genes and QTL involved in the fatty acid desaturation pathway in Brassica napus

A - Papers appearing in refereed journals
Smooker, A. M., Wells, R., Morgan, C., Beaudoin, F., Cho, K., Fraser, F. and Bancroft, I. 2011. The identification and mapping of candidate genes and QTL involved in the fatty acid desaturation pathway in Brassica napus. Theoretical and Applied Genetics. 122, pp. 1075-1090. https://doi.org/10.1007/s00122-010-1512-5

Identification and functional characterisation of genes encoding the omega-3 polyunsaturated fatty acid biosynthetic pathway from the coccolithophore Emiliania huxleyi

A - Papers appearing in refereed journals
Sayanova, O. V., Haslam, R. P., Venegas Caleron, M., Ruiz-Lopez, N., Worthy, C., Rooks, P., Allen, M. J. and Napier, J. A. 2011. Identification and functional characterisation of genes encoding the omega-3 polyunsaturated fatty acid biosynthetic pathway from the coccolithophore Emiliania huxleyi. Phytochemistry. 72, pp. 594-600. https://doi.org/10.1016/j.phytochem.2011.01.022

Foresight project on global food and farming futures: application of genetics and genomics to aquaculture development: current and future directions

A - Papers appearing in refereed journals
Mcandrew, B. and Napier, J. A. 2011. Foresight project on global food and farming futures: application of genetics and genomics to aquaculture development: current and future directions. The Journal of Agricultural Science. 149, pp. 143-151. https://doi.org/10.1017/S0021859610001152

Characterization of a glutenin-specific serine proteinase of Sunn bug Eurygaster integricepts Put.

A - Papers appearing in refereed journals
Konarev, A. V., Beaudoin, F., Marsh, J., Vilkova, N. A., Nefedova, L. I., Sivri, D., Koksel, H., Shewry, P. R. and Lovegrove, A. 2011. Characterization of a glutenin-specific serine proteinase of Sunn bug Eurygaster integricepts Put. Journal of Agricultural and Food Chemistry - JAFC. 59, pp. 2462-2470. https://doi.org/10.1021/jf103867g

ELVOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice

A - Papers appearing in refereed journals
Zadravec, D., Tvrdik, P., Guillou, H., Haslam, R. P., Kobayashi, T., Napier, J. A., Capecchi, M. R. and Jacobsson, A. 2011. ELVOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice. Journal Of Lipid Research. 52 (2), pp. 245-255. https://doi.org/10.1194/jlr.M011346

New Elongase Gene And Production Of Delta-9-polyunsaturated Fatty Acids (Patent EP 1373519 B1)

H1 - Patents granted
Napier, J. A., Lazarus, C. M., Qi, B. and Lerchl, J. 2010. New Elongase Gene And Production Of Delta-9-polyunsaturated Fatty Acids (Patent EP 1373519 B1). EP 1373519 B1

Semiochemical (Patent US 7820153 B2)

H1 - Patents granted
Hick, A. J., Pickett, J. A., Wadhams, L. J. and Napier, J. A. 2010. Semiochemical (Patent US 7820153 B2) . US 7820153 B2

Semiochemical (Patent US 2010/0226877 A1)

H2 - Patents applied for
Hick, A. J., Pickett, J. A., Wadhams, L. J. and Napier, J. A. 2010. Semiochemical (Patent US 2010/0226877 A1) . US 2010/0226877 A1

Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent WO 2010/066703 A2)

H2 - Patents applied for
Napier, J. A. 2010. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent WO 2010/066703 A2) . WO 2010/066703 A2

Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent CA 2744930 A1)

H2 - Patents applied for
Napier, J. A., Senger Toralf and Bauer Joerg 2010. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent CA 2744930 A1) . CA 2744930 A1

Process For The Production Of Δ5-unsaturated Fatty Acids In Transgenic Organisms (Patent US 7723574 B2)

H1 - Patents granted
Zank, T., Napier, J. A. and Sayanova, O. V. 2010. Process For The Production Of Δ5-unsaturated Fatty Acids In Transgenic Organisms (Patent US 7723574 B2). US 7723574 B2

Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2010/0043103 A1)

H2 - Patents applied for
Napier, J. A. and Sayanova, O. V. 2010. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2010/0043103 A1). US 2010/0043103 A1

Identification and characterization of novel natural alleles of eIF4E in barley providing broad-spectrum resistance to bymoviruses

C2 - Non-edited contributions to conferences
Hofinger, B. J., Bass, C., Baldwin, T., Jing, H-C., Beaudoin, F., Hammond-Kosack, K. E. and Kanyuka, K. 2010. Identification and characterization of novel natural alleles of eIF4E in barley providing broad-spectrum resistance to bymoviruses. Antoun, H., Trepanier, M., Prevost, D., Brisson, L. and Avis, T. (ed.) Biology of plant-microbe interactions, vol. 7 . International Society for Molecular Plant-Microbe Interactions, St. Paul. pp. Paper 71

Viral trans- dominant manipulation of algal sphingolipids

A - Papers appearing in refereed journals
Michaelson, L. V., Dunn, T. M. and Napier, J. A. 2010. Viral trans- dominant manipulation of algal sphingolipids. Trends in Plant Science. 15, pp. 651-655. https://doi.org/10.1016/j.tplants.2010.09.004

The production of Omega-3 Very Long-Chain Polyunsaturated Fatty Acids in transgenic plants: a sustainable source of omega-3 fish oils

C2 - Non-edited contributions to conferences
Ruiz-Lopez, N., Haslam, R. P., Sayanova, O. V. and Napier, J. A. 2010. The production of Omega-3 Very Long-Chain Polyunsaturated Fatty Acids in transgenic plants: a sustainable source of omega-3 fish oils.  Abstracts from the 51st International Conference on the Bioscience of Lipids. https://doi.org/10.1016/j.chemphyslip.2010.05.055

Very long chain fatty acids are required for cell polarity and organogenesis during plant development

C2 - Non-edited contributions to conferences
Molino, D., Markham, J. E., Bellec, Y., Gissot, L., Palauqui, J-C., Moreau, P., Napier, J. A. and Faure, J. D. 2010. Very long chain fatty acids are required for cell polarity and organogenesis during plant development. https://doi.org/10.1016/j.chemphyslip.2010.05.054

The transcriptome of cis -jasmone-induced resistance in Arabidopsis thaliana and its role in indirect defence

A - Papers appearing in refereed journals
Matthes, M. C., Bruce, T. J. A., Ton, J., Verrier, P. J., Pickett, J. A. and Napier, J. A. 2010. The transcriptome of cis -jasmone-induced resistance in Arabidopsis thaliana and its role in indirect defence. Planta. 232, pp. 1163-1180. https://doi.org/10.1007/s00425-010-1244-4

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