Loss of mechanical stiffness and the emergence of Lévy walks in active T cells

A - Papers appearing in refereed journals

Reynolds, A. M. 2021. Loss of mechanical stiffness and the emergence of Lévy walks in active T cells. Physics Letters A. 408 (27 Aug), p. 127507. https://doi.org/10.1016/j.physleta.2021.127507

AuthorsReynolds, A. M.
Abstract

The activation of T cells by the detection of substances not recognized by the immune system results in a more than threefold reduction of their mechanical stiffness and can also result in the occurrence of movement patterns that resemble Lévy walks. Here I show that Lévy walks with the run-pause characteristics of T cells have similitude with the predicted and observed movements of highly deformable particles. Predicted shape-dependent movements are consistent with observations of T cells progressing by a series of repeated lunges, becoming elongated while moving rapidly and balling up when paused.

KeywordsLevy walks; T cells; Multiplicative noise; Cell locomotion; Runs and pauses; Mechanical stiffness
Year of Publication2021
JournalPhysics Letters A
Journal citation408 (27 Aug), p. 127507
Digital Object Identifier (DOI)https://doi.org/10.1016/j.physleta.2021.127507
Open accessPublished as non-open access
FunderBiotechnology and Biological Sciences Research Council
Output statusPublished
Publication dates
Online10 Jun 2021
Publication process dates
Accepted03 Jun 2021
PublisherElsevier Science Bv
ISSN0375-9601

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