A - Papers appearing in refereed journals
Reynolds, A. M. 2021. Loss of mechanical stiffness and the emergence of Lévy walks in active T cells. Physics Letters A. 408 (27 Aug), p. 127507. https://doi.org/10.1016/j.physleta.2021.127507
Authors | Reynolds, A. M. |
---|---|
Abstract | The activation of T cells by the detection of substances not recognized by the immune system results in a more than threefold reduction of their mechanical stiffness and can also result in the occurrence of movement patterns that resemble Lévy walks. Here I show that Lévy walks with the run-pause characteristics of T cells have similitude with the predicted and observed movements of highly deformable particles. Predicted shape-dependent movements are consistent with observations of T cells progressing by a series of repeated lunges, becoming elongated while moving rapidly and balling up when paused. |
Keywords | Levy walks; T cells; Multiplicative noise; Cell locomotion; Runs and pauses; Mechanical stiffness |
Year of Publication | 2021 |
Journal | Physics Letters A |
Journal citation | 408 (27 Aug), p. 127507 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.physleta.2021.127507 |
Open access | Published as non-open access |
Funder | Biotechnology and Biological Sciences Research Council |
Output status | Published |
Publication dates | |
Online | 10 Jun 2021 |
Publication process dates | |
Accepted | 03 Jun 2021 |
Publisher | Elsevier Science Bv |
ISSN | 0375-9601 |
Permalink - https://repository.rothamsted.ac.uk/item/98542/loss-of-mechanical-stiffness-and-the-emergence-of-l-vy-walks-in-active-t-cells
Publisher's version