Worldwide emergence of resistance to antifungal drugs challenges human health and food security

A - Papers appearing in refereed journals

Fisher, M. C., Hawkins, N. J., Sanglard, D. and Gurr, S. J. 2018. Worldwide emergence of resistance to antifungal drugs challenges human health and food security. Science - AAAS. 360 (6390), pp. 739-742. https://doi.org/10.1126/science.aap7999

AuthorsFisher, M. C., Hawkins, N. J., Sanglard, D. and Gurr, S. J.
Abstract

The recent rate of emergence of pathogenic fungi that are resistant to the limited number of commonly used antifungal agents is unprecedented. The azoles, for example, are used not only for human and animal health care and crop protection but also in antifouling coatings and timber preservation. The ubiquity and multiple uses of azoles have hastened the independent evolution of resistance in many environments. One consequence is an increasing risk in human health care from naturally occurring opportunistic fungal pathogens that have acquired resistance to this broad class of chemicals. To avoid a global collapse in our ability to control fungal infections and to avoid critical failures in medicine and food security, we must improve our stewardship of extant chemicals, promote new antifungal discovery, and leverage emerging technologies for alternative solutions.

Year of Publication2018
JournalScience - AAAS
Journal citation360 (6390), pp. 739-742
Digital Object Identifier (DOI)https://doi.org/10.1126/science.aap7999
PubMed ID29773744
Open accessPublished as green open access
FunderBiotechnology and Biological Sciences Research Council
Natural Environment Research Council
Medical Research Council
Swiss National Science Foundation
Funder project or codeBBSRC Strategic Programme in Smart Crop Protection
Accepted author manuscript
Output statusPublished
Publication dates
Online18 May 2018
Copyright licenseCC BY
PublisherAmerican Association for the Advancement of Science (AAAS)
ISSN0036-8075
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