Whole grains, type 2 diabetes, coronary heart disease and hypertension: links to the aleurone preferred over indigestible fiber

A - Papers appearing in refereed journals

Lillioja, S., Neal, A. L., Tapsell, L. and Jacobs, D. R. Jr 2013. Whole grains, type 2 diabetes, coronary heart disease and hypertension: links to the aleurone preferred over indigestible fiber. Biofactors. 39 (3), pp. 242-258. https://doi.org/10.1002/biof.1077

AuthorsLillioja, S., Neal, A. L., Tapsell, L. and Jacobs, D. R. Jr
Abstract

Higher whole grain cereal intakes are associated with substantially lower risks of type 2 diabetes, coronary heart disease, and hypertension. These reduced risks have been established in large prospective studies that now include millions of person-years of follow-up. We analyze the results of 11 major prospective studies to provide recommendations about whole grain consumption. The following review establishes the amount of whole grains that should ideally be consumed based on prospective evidence; defines the nature of whole grains; identifies that the whole grain evidence is robust and not due to confounding; and provides a detailed assessment of several potential mechanisms for the effect of whole grains on health. We draw the following conclusions. Firstly, to maintain health, 40 grams or more of whole grains should be consumed daily. This is about a bowl of whole grain breakfast cereal daily, but 80% of the population does not achieve this. Secondly, aleurone in bran is a critical grain component generally overlooked in favor of indigestible fiber. Live aleurone cells constitute 50% of millers' bran. They store minerals, protein, and the antioxidant ferulic acid, and are clearly more than just indigestible fiber. Finally, we suggest potential roles for magnesium, zinc, and ferulic acid in the development of chronic disease. If the results of prospective studies were applied to the life-style practices of modern societies there exists the potential for enormous personal health and public financial benefits. (c) 2013 BioFactors, 2013

KeywordsBiochemistry ; Endocrinology ; Molecular biology; Metabolism
Year of Publication2013
JournalBiofactors
Journal citation39 (3), pp. 242-258
Digital Object Identifier (DOI)https://doi.org/10.1002/biof.1077
PubMed ID23355358
Open accessPublished as non-open access
FunderNational Cancer Institute
National Institute of Diabetes, Digestive, and Kidney Disease
Biotechnology and Biological Sciences Research Council
Funder project or codeDesigning Seeds for Nutrition and Health (DS)
Designing cereal seeds for nutrition and health
Output statusPublished
PublisherWiley
Copyright licenseCC BY
ISSN0951-6433

Permalink - https://repository.rothamsted.ac.uk/item/8qx18/whole-grains-type-2-diabetes-coronary-heart-disease-and-hypertension-links-to-the-aleurone-preferred-over-indigestible-fiber

Restricted files

Publisher's version

Under embargo indefinitely

41 total views
2 total downloads
3 views this month
0 downloads this month