Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses

A - Papers appearing in refereed journals

Lagator, M., Colegrave, N. and Neve, P. 2014. Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses. Proceedings of the Royal Society of London Series B Biological Sciences. 281 (1794).

AuthorsLagator, M., Colegrave, N. and Neve, P.
Abstract

In rapidly changing environments, selection history may impact the dynamics of adaptation. Mutations selected in one environment may result in pleiotropic fitness trade-offs in subsequent novel environments, slowing the rates of adaptation. Epistatic interactions between mutations selected in sequential stressful environments may slow or accelerate subsequent rates of adaptation, depending on the nature of that interaction. We explored the dynamics of adaptation during sequential exposure to herbicides with different modes of action in Chlamydomonas reinhardtii. Evolution of resistance to two of the herbicides was largely independent of selection history. For carbetamide, previous adaptation to other herbicide modes of action positively impacted the likelihood of adaptation to this herbicide. Furthermore, while adaptation to all individual herbicides was associated with pleiotropic fitness costs in stress-free environments, we observed that accumulation of resistance mechanisms was accompanied by a reduction in overall fitness costs. We suggest that antagonistic epistasis may be a driving mechanism that enables populations to more readily adapt in novel environments. These findings highlight the potential for sequences of xenobiotics to facilitate the rapid evolution of multiple-drug and -pesticide resistance, as well as the potential for epistatic interactions between adaptive mutations to facilitate evolutionary rescue in rapidly changing environments.

Keywordsenvironmental change; epistasis; pleiotropy; Adaptation; evolutionary; rescue; Xenobiotics; antibiotic-resistance; pseudomonas-aeruginosa; population-size; Evolution; cost
Year of Publication2014
JournalProceedings of the Royal Society of London Series B Biological Sciences
Journal citation281 (1794)
Digital Object Identifier (DOI)doi:10.1098/rspb.2014.1679
Open accessPublished as non-open access
FunderLeverhulme Trust
Output statusPublished
Publication dates
Online17 Sep 2014
Publication process dates
Accepted20 Aug 2014
ISSN09628452
PublisherRoyal Society Publishing
Copyright licensePublisher copyright

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