Adaptation at different points along antibiotic concentration gradients

A - Papers appearing in refereed journals

Lagator, M., Uecker, H. and Neve, P. 2021. Adaptation at different points along antibiotic concentration gradients. Biology Letters. 17, p. 20200913. https://doi.org/10.1098/rsbl.2020.0913

AuthorsLagator, M., Uecker, H. and Neve, P.
Abstract

Antibiotic concentrations vary dramatically in the body and the environment. Hence, understanding the dynamics of resistance evolution along antibiotic concentration gradients is critical for predicting and slowing the emergence
and spread of resistance. While it has been shown that increasing the concentration of an antibiotic slows resistance evolution, how adaptation to one antibiotic concentration correlates with fitness at other points along the gradient has not received much attention. Here, we selected populations of Escherichia coli at several points along a concentration gradient for three different antibiotics, asking how rapidly resistance evolved and whether populations became specialized to the antibiotic concentration they were selected on. Populations selected at higher concentrations evolved resistance more slowly but
exhibited equal or higher fitness across the whole gradient. Populations selected at lower concentrations evolved resistance rapidly, but overall fitness in the presence of antibiotics was lower. However, these populations readily
adapted to higher concentrations upon subsequent selection. Our results indicate that resistance management strategies must account not only for the rates of resistance evolution but also for the fitness of evolved strains.

KeywordsAntibiotic resistance; Drug dose; Adaptation
Year of Publication2021
JournalBiology Letters
Journal citation17, p. 20200913
Digital Object Identifier (DOI)https://doi.org/10.1098/rsbl.2020.0913
Open accessPublished as ‘gold’ (paid) open access
FunderBiotechnology and Biological Sciences Research Council
Wellcome Trust
Publisher's version
Output statusPublished
Publication dates
Online12 May 2021
Publication process dates
Accepted19 Apr 2021
ISSN1744-9561
PublisherRoyal Society Publishing

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