RNAi targets in Agricultural Pest Insects: Advancements, knowledge gaps, and IPM

A - Papers appearing in refereed journals

Willow, J., Taning, C. N. T., Cook, S. M., Sulg, S., Silva, A. I., Smagghe, G. and Veromann, E. 2021. RNAi targets in Agricultural Pest Insects: Advancements, knowledge gaps, and IPM. Frontiers in Agronomy. 3, p. 794312. https://doi.org/10.3389/fagro.2021.794312

AuthorsWillow, J., Taning, C. N. T., Cook, S. M., Sulg, S., Silva, A. I., Smagghe, G. and Veromann, E.
Abstract

The unprecedented target-specificity of double-stranded RNA (dsRNA), due to its sequence-specific mode of action, puts dsRNA at the forefront of biosafe insecticide technology. Since 2007, sensitive target genes have been identified in numerous crop pest insects, with an end goal of applying RNA interference (RNAi) in pest management. Key RNAi targets identified include genes involved in (1) feeding and digestion, (2) production of dsRNases, (3) resistance to insecticides and plant allelochemicals, (4) reproductive fitness, and (5) transmission of plant viruses. Despite the advances, there remain critical knowledge gaps in each of these areas. Particular emphasis must be
placed on ensuring RNAi’s compatibility with integrated pest management (IPM), via further identification of molecular targets that reduce crop damage while sustaining pest
(host) populations for highly specialized biocontrol agents, the latter representing a core
pillar of IPM.

KeywordsRNA interference ; Molecular targets; Integrated pest management; Crop production; Agronomy; Gene silencing; Insecticide; Biopesticide
Year of Publication2021
JournalFrontiers in Agronomy
Journal citation3, p. 794312
Digital Object Identifier (DOI)https://doi.org/10.3389/fagro.2021.794312
Web address (URL)https://www.frontiersin.org/articles/10.3389/fagro.2021.794312/full
Open accessPublished as ‘gold’ (paid) open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeBBSRC Strategic Programme in Smart Crop Protection
Publisher's version
Output statusPublished
Publication dates
Online10 Dec 2021
Publication process dates
Accepted19 Nov 2021
PublisherFrontiers Media SA
ISSN2673-3218

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