The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance

A - Papers appearing in refereed journals

Brown, N. A. and Goldman, G. H. 2016. The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance. Journal of Microbiology. 54, pp. 243-253.

AuthorsBrown, N. A. and Goldman, G. H.

Invasive aspergillosis has emerged as one of the most common life-threatening fungal disease of humans. The emergence of antifungal resistant pathogens represents a current and increasing threat to society. In turn, new strategies to combat fungal infection are urgently required. Fungal adaptations to stresses experienced within the human host are a prerequisite for the survival and virulence strategies of the pathogen. Here, we review the latest information on the signalling pathways in Aspergillus fumigatus that contribute to stress adaptations and virulence, while highlighting their potential as targets for the development of novel combinational antifungal therapies.

Year of Publication2016
JournalJournal of Microbiology
Journal citation54, pp. 243-253
Digital Object Identifier (DOI)doi:10.1007/s12275-016-5510-4
Open accessPublished as non-open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeWheat
Pathogen-Host Interactions Database: PHI Database [2012-2017]
[20:20 Wheat] Protecting yield potential of wheat
PhytoPath, an infrastructure for hundreds of plant pathogen genomes [2014-2017]
Output statusPublished
Publication dates
Online27 Feb 2016
Publication process dates
Accepted22 Oct 2015
Microbiological Society Korea
Copyright licensePublisher copyright

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