The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance
A - Papers appearing in refereed journals
Brown, N. A. and Goldman, G. H. 2016. The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance. Journal of Microbiology. 54, pp. 243-253. https://doi.org/10.1007/s12275-016-5510-4
| Authors | Brown, N. A. and Goldman, G. H. |
|---|---|
| Abstract | Invasive aspergillosis has emerged as one of the most common life-threatening fungal disease of humans. The emergence of antifungal resistant pathogens represents a current and increasing threat to society. In turn, new strategies to combat fungal infection are urgently required. Fungal adaptations to stresses experienced within the human host are a prerequisite for the survival and virulence strategies of the pathogen. Here, we review the latest information on the signalling pathways in Aspergillus fumigatus that contribute to stress adaptations and virulence, while highlighting their potential as targets for the development of novel combinational antifungal therapies. |
| Year of Publication | 2016 |
| Journal | Journal of Microbiology |
| Journal citation | 54, pp. 243-253 |
| Digital Object Identifier (DOI) | https://doi.org/10.1007/s12275-016-5510-4 |
| Open access | Published as non-open access |
| Funder | Biotechnology and Biological Sciences Research Council |
| Funder project or code | Wheat |
| Pathogen-Host Interactions Database: PHI Database [2012-2017] | |
| [20:20 Wheat] Protecting yield potential of wheat | |
| PhytoPath, an infrastructure for hundreds of plant pathogen genomes | |
| Output status | Published |
| Publication dates | |
| Online | 27 Feb 2016 |
| Publication process dates | |
| Accepted | 22 Oct 2015 |
| Publisher | Springer |
| Microbiological Society Korea | |
| Copyright license | Publisher copyright |
| ISSN | 1225-8873 |
Related outputs
GPCR-mediated glucose sensing system regulates light-dependent fungal development and mycotoxin production
A - Papers appearing in refereed journals
Dos Reis, T. F., Mellado, L., Lohmar, J. M., Pereira Silva, L., Zhou, J-J., Calvo, A. M., Goldman, G. H. and Brown, N. A. 2019. GPCR-mediated glucose sensing system regulates light-dependent fungal development and mycotoxin production. PLOS Genetics. 15 (10), p. e1008419. https://doi.org/10.1371/journalpgen.1008419
Non-canonical fungal G-protein coupled receptors promote Fusarium head blight on wheat
A - Papers appearing in refereed journals
Dilks, T., Halsey, K., De Vos, R., Hammond-Kosack, K. E. and Brown, N. A. 2019. Non-canonical fungal G-protein coupled receptors promote Fusarium head blight on wheat. PLOS Pathogens. 15 (4), p. e1007666. https://doi.org/10.1371/journal.ppat.1007666
Fungal G-protein-coupled receptors: mediators of pathogenesis and targets for disease control
A - Papers appearing in refereed journals
Brown, N. A., Schrevens, S., Van Dijck, P. and Goldman, G. H. 2018. Fungal G-protein-coupled receptors: mediators of pathogenesis and targets for disease control. Nature Microbiology. 3 (4), pp. 402-414. https://doi.org/10.1038/s41564-018-0127-5
Inter-genome comparison of the Quorn fungus Fusarium venenatum and the closely related plant infecting pathogen Fusarium graminearum
A - Papers appearing in refereed journals
King, R., Brown, N. A., Urban, M. and Hammond-Kosack, K. E. 2018. Inter-genome comparison of the Quorn fungus Fusarium venenatum and the closely related plant infecting pathogen Fusarium graminearum. BMC Genomics. 19, p. 269. https://doi.org/10.1186/s12864-018-4612-2
Sharing mutants and experimental information prepublication using FgMutantDb (https://scabusa.org/FgMutantDb)
A - Papers appearing in refereed journals
Baldwin, T. T., Basenko, E., Harb, O., Brown, N. A., Urban, M., Hammond-Kosack, K. E. and Bregitzer, P. P. 2018. Sharing mutants and experimental information prepublication using FgMutantDb (https://scabusa.org/FgMutantDb). Fungal Genetics and Biology. 115 (June), pp. 90-93. https://doi.org/10.1016/j.fgb.2018.01.002
The putative flavin carrier family FlcA-C is important for Aspergillus fumigatus virulence
A - Papers appearing in refereed journals
De Castro, P. A., Chiaratto, J., Morais, E. R., Dos Reis, T. F., Mitchell, T. K., Brown, N. A. and Goldman, G. H. 2017. The putative flavin carrier family FlcA-C is important for Aspergillus fumigatus virulence. Virulence. 8 (6), pp. 797-809. https://doi.org/10.1080/21505594.2016.1239010
RNAi as an emerging approach to control Fusarium Head Blight disease and mycotoxin contamination in cereals
A - Papers appearing in refereed journals
Machado, A., Brown, N. A., Urban, M., Kanyuka, K. and Hammond-Kosack, K. E. 2017. RNAi as an emerging approach to control Fusarium Head Blight disease and mycotoxin contamination in cereals. Pest Management Science. 74 (4), pp. 790-799. https://doi.org/10.1002/ps.4748
A spatial temporal analysis of the Fusarium graminearum transcriptome during symptomless and symptomatic wheat infection
A - Papers appearing in refereed journals
Brown, N. A., Evans, J., Mead, A. and Hammond-Kosack, K. E. 2017. A spatial temporal analysis of the Fusarium graminearum transcriptome during symptomless and symptomatic wheat infection. Molecular Plant Pathology. 18 (9), pp. 1295-1312. https://doi.org/10.1111/mpp.12564
Genome-wide transcriptome analysis of Aspergillus fumigatus exposed to osmotic stress reveals regulators of osmotic and cell wall stresses that are SakA(HOG1) and MpkC dependent.
A - Papers appearing in refereed journals
Pereira Silva, L., De Castro, P. A., Dos Reis, T. F., Paziani, M. H., Von Zeska Kress, M. R., Riano-Pachon, D. M., Hagiwara, D., Ries, L. N. A., Brown, N. A. and Goldman, G. H. 2017. Genome-wide transcriptome analysis of Aspergillus fumigatus exposed to osmotic stress reveals regulators of osmotic and cell wall stresses that are SakA(HOG1) and MpkC dependent. Cellular Microbiology. 19 (4), p. e12681. https://doi.org/10.1111/cmi.12681
The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence
A - Papers appearing in refereed journals
Alves de Castro, P., Dos Reis, Thaila F., Dolan, S. K., Oliveira Manfiolli, A., Brown, N. A., Jones, G. W., Doyle, S., Riano-Pachon, D. M., Squina, F. M., Caldana, C., Singh, A., Del Poeta, M., Hagiwara, D., Silva-Rocha, R. and Goldman, G. H. 2016. The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence. Molecular Microbiology. 102 (4), pp. 642-671. https://doi.org/10.1111/mmi.13484
Mitogen activated protein kinases SakA(HOG1) and MpkC collaborate for Aspergillus fumigatus virulence
A - Papers appearing in refereed journals
Nascimento, Acmdb, Dos Reis, T. F., De Castro, P. A., Hori, J. I., Bom, V. L. P., De Assis, L. J., Ramalho, L. N. Z., Rocha, M. C., Malavazi, I., Brown, N. A., Valiante, V., Brakhage, A. A., Hagiwara, D. and Goldman, G. H. 2016. Mitogen activated protein kinases SakA(HOG1) and MpkC collaborate for Aspergillus fumigatus virulence. Molecular Microbiology. 100 (5), pp. 841-859. https://doi.org/10.1111/mmi.13354
RNAseq reveals hydrophobins that are involved in the adaptation of Aspergillus nidulans to lignocellulose
A - Papers appearing in refereed journals
Brown, N. A., Ries, L. N. A., Reis, T. F., Rajendran, R., Correa dos Santos, R. A., Ramage, G., Riano-Pachon, D. M. and Goldman, G. H. 2016. RNAseq reveals hydrophobins that are involved in the adaptation of Aspergillus nidulans to lignocellulose. Biotechnology for Biofuels. 9, p. 145. https://doi.org/10.1186/s13068-016-0558-2
The trans-kingdom identification of negative regulators of pathogen hypervirulence
A - Papers appearing in refereed journals
Brown, N. A., Urban, M. and Hammond-Kosack, K. E. 2016. The trans-kingdom identification of negative regulators of pathogen hypervirulence. FEMS Microbiology Reviews. 40 (1), pp. 19-40. https://doi.org/10.1093/femsre/fuv042
Aspergillus nidulans protein kinase A plays an important role in cellulase production
A - Papers appearing in refereed journals
De Assis, L. J., Ries, L. N. A., Savoldi, M., Dos Reis, T. F., Brown, N. A. and Goldman, G. H. 2015. Aspergillus nidulans protein kinase A plays an important role in cellulase production. Biotechnology for Biofuels. 8, p. 213. https://doi.org/10.1186/s13068-015-0401-1
Secreted biomolecules in fungal plant pathogenesis
B - Book chapters etc edited externally
Brown, N. A. and Hammond-Kosack, K. E. 2015. Secreted biomolecules in fungal plant pathogenesis. in: Gupta, V. K., Sreenivasaprasad, S. and Mach, R. L. (ed.) Fungal biomolecules: sources, applications and recent developments John Wiley & Sons Chichester, West Sussex. pp. 263-310
The Aspergillus fumigatus pkcA G579R mutant is defective in the activation of the cell wall integrity pathway but is dispensable for virulence in a neutropenic mouse infection model
A - Papers appearing in refereed journals
Rocha, M. C., De Godoy, K. F., De Castro, P. A., Hori, J. I., Bom, V. L. P., Brown, N. A., Da Cunha, A. F., Goldman, G. H. and Malavazi, I. 2015. The Aspergillus fumigatus pkcA G579R mutant is defective in the activation of the cell wall integrity pathway but is dispensable for virulence in a neutropenic mouse infection model. PLOS ONE. 10, p. e0135195. https://doi.org/10.1371/journal.pone.0135195
G‐protein coupled receptor‐mediated nutrient sensing and developmental control in Aspergillus nidulans
A - Papers appearing in refereed journals
Brown, N. A., Dos Reis, T. F., Ries, L. N. A., Caldana, C., Mah, J-H., Yu, J-H., Macdonald, J. M. and Goldman, G. H. 2015. G‐protein coupled receptor‐mediated nutrient sensing and developmental control in Aspergillus nidulans. Molecular Microbiology. 98 (3), pp. 420-439. https://doi.org/10.1111/mmi.13135
An interspecies comparative analysis of the predicted secretomes of the necrotrophic plant pathogens Sclerotinia sclerotiorum and Botrytis cinerea
A - Papers appearing in refereed journals
Heard, S., Brown, N. A. and Hammond-Kosack, K. E. 2015. An interspecies comparative analysis of the predicted secretomes of the necrotrophic plant pathogens Sclerotinia sclerotiorum and Botrytis cinerea. PLOS ONE. 10, p. e0130534. https://doi.org/10.1371/journal.pone.0130534
Exploring the early symptomless phase of Fusarium graminearum infection of wheat ears
C2 - Non-edited contributions to conferences
Hammond-Kosack, K. E., Brown, N. A., Urban, M. and Antoniw, J. F. 2012. Exploring the early symptomless phase of Fusarium graminearum infection of wheat ears. Abstracts 11th European Conference on Fungal Genetics, Marburg, 30 March - 2 April 2012 . pp. 74
The 26th Fungal Genetics Conference, Asilomar, USA, 15th-20th March 2011
G - Articles in popular magazines and other technical publications
Gurr, S. J., Dyer, P. S., Brown, N. A., Urban, M. and Tauati, S. 2012. The 26th Fungal Genetics Conference, Asilomar, USA, 15th-20th March 2011. BSPP News. 67, pp. 20-25.
The predicted secretome of the plant pathogenic fungus Fusarium graminearum: a refined comparative analysis
A - Papers appearing in refereed journals
Brown, N. A., Antoniw, J. F. and Hammond-Kosack, K. E. 2012. The predicted secretome of the plant pathogenic fungus Fusarium graminearum: a refined comparative analysis. PLOS ONE. 7, p. e33731 (14pp). https://doi.org/10.1371/journal.pone.0033731
A comparison of the infection biology and transcriptome of wild-type and single gene deletion strains of Fusarium graminearum
F - Theses
Brown, N. A. 2011. A comparison of the infection biology and transcriptome of wild-type and single gene deletion strains of Fusarium graminearum. F - Theses
Characterisation of the Fusarium graminearum-wheat floral interaction
A - Papers appearing in refereed journals
Brown, N. A., Bass, C. G., Baldwin, T. K., Chen, Huaigu, Massot, F., Carion, P. W. C., Urban, M., Van De Meene, A. M. L. and Hammond-Kosack, K. E. 2011. Characterisation of the Fusarium graminearum-wheat floral interaction. Journal of Pathogens. 2011, p. 626345. https://doi.org/10.4061/2011/626345
Infection of the wheat ear by the fungus Fusarium culmorum
C2 - Non-edited contributions to conferences
Van De Meene, A., Urban, M., Brown, N. A. and Hammond-Kosack, K. E. 2011. Infection of the wheat ear by the fungus Fusarium culmorum. Abstracts Botanical Microscopy Conference, Wageningen, 16-21 April 2011 .
The unseen threat of symptomless Fusarium wheat ear infection
C1 - Edited contributions to conferences/learned societies
Brown, N. A., Bass, C. G., Urban, M., Van De Meene, A. and Hammond-Kosack, K. E. 2011. The unseen threat of symptomless Fusarium wheat ear infection. Crop protection in Southern Britain. Aspects of Applied Biology 106 . pp. 143-149
The unseen threat to UK wheat production from Fusarium ear blight
C2 - Non-edited contributions to conferences
Brown, N. A., Bass, C. G., Urban, M., Van De Meene, A. and Hammond-Kosack, K. E. 2010. The unseen threat to UK wheat production from Fusarium ear blight. Abstracts CropWorld, London, 1-3 November 2010 .
Be more specific! Using laser capture micro-dissection to investigate Fusarium ear blight
C2 - Non-edited contributions to conferences
Brown, N. A., Urban, M., Van De Meene, A. and Hammond-Kosack, K. E. 2010. Be more specific! Using laser capture micro-dissection to investigate Fusarium ear blight. Abstracts 9th International Mycological Congress: the Biology of Fungi, Edinburgh, 1-6 August 2010 .
The infection biology of Fusarium graminearum: defining the pathways of spikelet to spikelet colonisation in wheat ears
A - Papers appearing in refereed journals
Brown, N. A., Urban, M., Van De Meene, A. M. L. and Hammond-Kosack, K. E. 2010. The infection biology of Fusarium graminearum: defining the pathways of spikelet to spikelet colonisation in wheat ears. Fungal Biology. 114 (7), pp. 555-571. https://doi.org/10.1016/j.funbio.2010.04.006
A role for topoisomerase I in Fusarium graminearum and F. culmorum pathogenesis and sporulation
A - Papers appearing in refereed journals
Baldwin, T. K., Urban, M., Brown, N. A. and Hammond-Kosack, K. E. 2010. A role for topoisomerase I in Fusarium graminearum and F. culmorum pathogenesis and sporulation. Molecular Plant-Microbe Interactions - MPMI. 23 (5), pp. 566-577. https://doi.org/10.1094/MPMI-23-5-0566
Molecular and genetic studies on Fusarium Ear Blight disease of wheat
C2 - Non-edited contributions to conferences
Hammond-Kosack, K. E., Kanyuka, K., Brown, N. A., Beacham, A. M., Cuzick, A., Antoniw, J. F. and Urban, M. 2009. Molecular and genetic studies on Fusarium Ear Blight disease of wheat. Abstracts 2009 National Fusarium Head Blight Forum, Orlando, 7-9 December 2009 .
The infection biology and transcriptome of wheat pathogen Fusarium graminearum
C2 - Non-edited contributions to conferences
Brown, N. A., Urban, M., Van De Meene, A. and Hammond-Kosack, K. E. 2008. The infection biology and transcriptome of wheat pathogen Fusarium graminearum. Abstracts Syngenta Student Showcase, Jealott's Hill, 16 September 2008 .
The infection biology and transcriptome of wheat pathogen Fusarium graminearum
C2 - Non-edited contributions to conferences
Brown, N. A., Urban, M., Van De Meene, A. and Hammond-Kosack, K. E. 2008. The infection biology and transcriptome of wheat pathogen Fusarium graminearum. Abstracts BSPP Presidential Meeting on Cereal Pathosystems, London, 16-17 December 2008 . pp. 13
The infection biology of Fusarium graminearum single gene deletion strains
C2 - Non-edited contributions to conferences
Brown, N. A., Baldwin, T., Urban, M., Van De Meene, A. and Hammond-Kosack, K. E. 2008. The infection biology of Fusarium graminearum single gene deletion strains. Abstracts 9th European Conference on Fungal Genetics (ECFG9), Edinburgh, 5-8 April 2008 .
Changes in protein secondary structure during gluten deformation studied by dynamic Fourier transform infrared spectroscopy
A - Papers appearing in refereed journals
Wellner, N., Mills, E. N. C., Brownsey, G., Wilson, R. H., Brown, N. A., Freeman, J., Halford, N. G., Shewry, P. R. and Belton, P. S. 2005. Changes in protein secondary structure during gluten deformation studied by dynamic Fourier transform infrared spectroscopy. Biomacromolecules. 6 (1), pp. 255-261. https://doi.org/10.1021/bm049584d
Structure and biomechanical properties of the gluten proteins deposited in the developing wheat grain: relationship to functional properties at harvest
C1 - Edited contributions to conferences/learned societies
Shewry, P. R., Wellner, N., Mills, E. N. C., Brownsey, G., Wilson, R. H., Brown, N. A., Freeman, J., Halford, N. G. and Belton, P. S. 2004. Structure and biomechanical properties of the gluten proteins deposited in the developing wheat grain: relationship to functional properties at harvest. Black, C. K., Rebetzke, G. J. and Panozzo, J. F. (ed.) Cereals 2004: Proceedings 54th Australian Cereal Chemistry Conference and 11th Wheat Breeders' Assembly, Canberra, 21-24 September 2004 . Royal Australian Chemical Institute, Melbourne. pp. 377-379
Permalink - https://repository.rothamsted.ac.uk/item/8v19w/the-contribution-of-aspergillus-fumigatus-stress-responses-to-virulence-and-antifungal-resistance